SLC22A1

• organic cation transporter 1

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/22 15:54:13」(JST)

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Solute carrier family 22 (organic cation transporter), member 1
Identifiers
Symbols	SLC22A1; HOCT1; OCT1; oct1_cds
External IDs	OMIM: 602607 MGI: 108111 HomoloGene: 20665 ChEMBL: 5685 GeneCards: SLC22A1 Gene
Gene Ontology Molecular function • acetylcholine transmembrane transporter activity • dopamine transmembrane transporter activity • norepinephrine transmembrane transporter activity • protein binding • secondary active organic cation transmembrane transporter activity • organic cation transmembrane transporter activity • identical protein binding Cellular component • plasma membrane • integral to plasma membrane • membrane • basolateral plasma membrane Biological process • drug transmembrane transport • establishment or maintenance of transmembrane electrochemical gradient • organic cation transport • dopamine transport • norepinephrine transport • small molecule metabolic process • epinephrine transport • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6580	20517
Ensembl	ENSG00000175003	ENSMUSG00000023829
UniProt	O15245	O08966
RefSeq (mRNA)	NM_003057	NM_009202
RefSeq (protein)	NP_003048	NP_033228
Location (UCSC)	Chr 6: 160.54 – 160.58 Mb	Chr 17: 12.65 – 12.68 Mb
PubMed search	[1]	[2]

Solute carrier family 22 member 1 is a protein that in humans is encoded by the SLC22A1 gene.

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.

See also

• Solute carrier family
• Organic cation transport proteins

References

Further reading

• Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. PMC 238269. PMID 1727476. 
• Jeang KT, Chun R, Lin NH et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421. 
• Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060. 
• Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 ( Pt 1) (Pt 1): 155–8. PMC 1218171. PMID 9078256. 
• Zhang L, Dresser MJ, Gray AT et al. (1997). "Cloning and functional expression of a human liver organic cation transporter". Mol. Pharmacol. 51 (6): 913–21. PMID 9187257. 
• Gorboulev V, Ulzheimer JC, Akhoundova A et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930. 
• Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568. 
• Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551. 
• Tomilin A, Reményi A, Lins K et al. (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell 103 (6): 853–64. doi:10.1016/S0092-8674(00)00189-6. PMID 11136971. 
• Hayer M, Bönisch H, Brüss M (2001). "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)". Ann. Hum. Genet. 63 (Pt 6): 473–82. doi:10.1017/S0003480099007770. PMID 11388889. 
• Pietig G, Mehrens T, Hirsch JR et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227. 
• Pan H, Qin WX, Huo KK et al. (2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics 77 (1–2): 58–64. doi:10.1006/geno.2001.6614. PMID 11543633. 
• Xu XR, Huang J, Xu ZG et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456. 
• Schinkel AH, Jonker JW (2003). "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics 12 (8): 589–90. doi:10.1097/00008571-200211000-00001. PMID 12439217. 
• Kerb R, Brinkmann U, Chatskaia N et al. (2003). "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences". Pharmacogenetics 12 (8): 591–5. doi:10.1097/00008571-200211000-00002. PMID 12439218. 
• Schaffer A, Kim EC, Wu X et al. (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812. 
• Shu Y, Leabman MK, Feng B et al. (2003). "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 5902–7. doi:10.1073/pnas.0730858100. PMC 156299. PMID 12719534. 
• Sakata T, Anzai N, Shin HJ et al. (2004). "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions". Biochem. Biophys. Res. Commun. 313 (3): 789–93. doi:10.1016/j.bbrc.2003.11.175. PMID 14697261. 
• Bottalico B, Larsson I, Brodszki J et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells.

• Zhu P, Hata R, Ogasawara M, Cao F, Kameda K, Yamauchi K, Schinkel AH, Maeyama K, Sakanaka M.SourceDepartment of Functional Histology, Ehime University Graduate School of Medicine, Ehime, Japan.
• Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.J Cereb Blood Flow Metab.2012 Oct;32(10):1897-908. doi: 10.1038/jcbfm.2012.92. Epub 2012 Jun 27.
• The organic cation transporters OCT1, 2, and 3 (SLC22A1-3) have been implicated in the elimination of biogenic amines such as histamine. Among them, OCT3 was identified as an uptake-2 transporter, responsible for clearance of histamine. Because increasing evidence suggests the involvement of histami
• PMID 22739622

• Effects of culture duration on gene expression of p450 isoforms, uptake and efflux transporters in primary hepatocytes cultured in the absence and presence of interleukin- 6: implications for experimental design for the evaluation of downregulatory effects of biotherapeutics.

• Yang Q, Doshi U, Li N, Li AP.SourceIn vitro ADMET Laboratories LLC, 9221 Rumsey Road, Columbia, MD 21045, USA.
• Current drug metabolism.Curr Drug Metab.2012 Sep 1;13(7):938-46.
• We report here a comprehensive evaluation of the effects of culture duration on the gene expression of P450 isoforms, uptake transporters and efflux transporters in human hepatocyte cultured in the absence and presence of the prototypical proinflammatory cytokine, interleukin-6 (IL-6). Primary colla
• PMID 22475270

Japanese Journal

• Screening of genetic variations of SLC15A2, SLC22A1, SLC22A2 and SLC22A6 genes

• Cheong Hyun Sub,Kim Hae Deun,Na Han Sung [他],KIM Ji On,KIM Lyoung Hyo,KIM Seung Hee,BAE Joon Seol,CHUNG Myeon Woo,SHIN Hyoung Doo
• Journal of human genetics 56(9), 666-670, 2011-09-01
• NAID 10030660904

• Association of SLCO1B3 Polymorphism with Intracellular Accumulation of Imatinib in Leukocytes in Patients with Chronic Myeloid Leukemia

• Nambu Takeru,Hamada Akinobu,Nakashima Reiko [他],Yuki Misato,Kawaguchi Tatsuya,Mitsuya Hiroaki,Saito Hideyuki
• Biological and Pharmaceutical Bulletin 34(1), 114-119, 2011
• … In the present study, we investigated the correlation between intracellular imatinib concentrations in leukocytes, plasma imatinib levels, and genotypes of drug transporters, including ATP binding cassette B1 (ABCB), ABCG2, solute carrier 22A1 (SLC22A1), solute carrier organic anion transporter family members 1B1 (SLCO1B1) and SLCO1B3. …
• NAID 130000402273

• Effect of Glucocorticoid Receptor Ligand Dexamethasone on the Expression of Organic Cation Transporter in Rat Liver

• MAEDA Tomoji,YOTSUMOTO Takafumi,OYABU Masanobu,TAMAI Ikumi
• Drug metabolism and pharmacokinetics 23(1), 67-72, 2008-02-25
• …   Since rat organic cation transporter 1 (Oct1, Slc22a1) is expressed mainly in the liver and mediates drug transport, its activity may determine the hepatic handling of cationic drugs. …
• NAID 10024187802

Related Links

• SLC22A1 - The Pharmacogenomics Knowledge Base

View gene SLC22A1 on PharmGKB. ... The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant.

• SLC22A1 Gene - GeneCards | S22A1 Protein | S22A1 Antibody

... noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor Gene ...

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