関: NFI transcription factor、nuclear factor-1

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
(weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
『核の』,細胞核の / [『原子』]『核の』
『私は』私が
iodineの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/19 14:51:42」(JST)

wiki en

Nuclear factor I (NF-I) is a family of closely related transcription factors. They constitutively bind as dimers to specific sequences of DNA with high affinity.^[1] Family members contain an unusual DNA binding domain that binds to the recognition sequence 5'-TTGGCXXXXXGCCAA-3'.^[2]

Subtypes include:

NFIA
NFIB
NFIC
NFIX

References[edit]

^ Blomquist P, Belikov S, Wrange O (January 1999). "Increased nuclear factor 1 binding to its nucleosomal site mediated by sequence-dependent DNA structure". Nucleic Acids Res. 27 (2): 517–25. doi:10.1093/nar/27.2.517. PMC 148209. PMID 9862974. Cite uses deprecated parameters (help)
^ Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. pp. 125–126. ISBN 1-4160-2328-3.

UpToDate Contents

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English Journal

PMID 28122918

Nuclear Factor One transcription factors as epigenetic regulators in cancer.

Fane M1,2, Harris L1, Smith AG2,3, Piper M1.
International journal of cancer.Int J Cancer.2017 Jan 11. doi: 10.1002/ijc.30603. [Epub ahead of print]
Tumour heterogeneity poses a distinct obstacle to therapeutic intervention. While the initiation of tumours across various physiological systems is frequently associated with signature mutations in genes that drive proliferation and bypass senescence, increasing evidence suggests that tumour progres
PMID 28076901

A novel NFIA-NFκB feed-forward loop contributes to glioblastoma cell survival.

Lee J1, Hoxha E1, Song HR2.
Neuro-oncology.Neuro Oncol.2016 Dec 18. pii: now233. [Epub ahead of print]
BACKGROUND: The nuclear factor I-A (NFIA) transcription factor promotes glioma growth and inhibits apoptosis in glioblastoma (GBM) cells. Here we report that the NFIA pro-survival effect in GBM is mediated in part via a novel NFIA-nuclear factor-kappaB (NFκB) p65 feed-forward loop.METHODS: We exami
PMID 27994064

Japanese Journal

Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues

Demura Masashi,Wang Fen,Yoneda Takashi,Karashima Shigehiro,Mori Shunsuke,Oe Masashi,Kometani Mitsuhiro,Sawamura Toshitaka,Cheng Yuan,Maeda Yuji,Namiki Mikio,Ino Hidekazu,Fujino Noboru,Uchiyama Katsuharu,Tsubokawa Toshinari,Yamagishi Masakazu,Nakamura Yasuhiro,Ono Katsuhiko,Sasano Hironobu,Demura Yoshiki,Takeda Yoshiyu　　
Journal of Hypertension 29(6), 1185-1195, 2011-06
… Objective: Nuclear receptors are involved in a wide variety of functions, including aldosteronogenesis. …
NAID 120003141563

RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis

Funasaka Tatsuyoshi,Nakano Hiroshi,Wu Yu,Hashizume Chieko,Gu Ling,Nakamura Takuro,Wang Wei,Zhou Pengbo,Moore Malcolm AS,Sato Hiroshi,Wong Richard W.
Cell Cycle 10(9), 1456-1467, 2011-05-01
… All the fusion proteins have an identical NUP98 N terminus, which contains the GLEBS motif for interaction with the mRNA export factor RAE1 and FG repeats that associate with the transcription factors HDAC1 and p300. …
NAID 120003141916