WordNet
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
PrepTutorEJDIC
- nucleusの複数形
- 『核の』,細胞核の / [『原子』]『核の』
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/24 07:58:46」(JST)
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- 1. 小児における核上性注視異常 supranuclear disorders of gaze in children
- 2. 脳深部刺激装置の埋込を行う患者のための麻酔 anesthesia for patients having deep brain stimulator implantation
- 3. 瞳孔不同患者へのアプローチ approach to the patient with anisocoria
- 4. 視床下部下垂体軸 hypothalamic pituitary axis
- 5. 好中球二次顆粒欠損症 neutrophil specific granule deficiency
English Journal
- Phototoxic effects of lysosome-associated genetically encoded photosensitizer KillerRed.
- Serebrovskaya EO1, Ryumina AP1, Boulina ME1, Shirmanova MV2, Zagaynova EV2, Bogdanova EA1, Lukyanov SA3, Lukyanov KA1.Author information 1Russian Academy of Sciences, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997, Moscow, Russia.2Nizhny Novgorod State Medical Academy, 603005 Minin Sq., 10/1, 603005, Nizhny Novgorod, Russia.3Russian Academy of Sciences, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997, Moscow, RussiabNizhny Novgorod State Medical Academy, 603005 Minin Sq., 10/1, 603005, Nizhny Novgorod, Russia.AbstractKillerRed is a unique phototoxic red fluorescent protein that can be used to induce local oxidative stress by green-orange light illumination. Here we studied phototoxicity of KillerRed targeted to cytoplasmic surface of lysosomes via fusion with Rab7, a small GTPase that is known to be attached to membranes of late endosomes and lysosomes. It was found that lysosome-associated KillerRed ensures efficient light-induced cell death similar to previously reported mitochondria- and plasma membrane-localized KillerRed. Inhibitory analysis demonstrated that lysosomal cathepsins play an important role in the manifestation of KillerRed-Rab7 phototoxicity. Time-lapse monitoring of cell morphology, membrane integrity, and nuclei shape allowed us to conclude that KillerRed-Rab7-mediated cell death occurs via necrosis at high light intensity or via apoptosis at lower light intensity. Potentially, KillerRed-Rab7 can be used as an optogenetic tool to direct target cell populations to either apoptosis or necrosis.
- Journal of biomedical optics.J Biomed Opt.2014 Jul;19(7):071403. doi: 10.1117/1.JBO.19.7.071403.
- KillerRed is a unique phototoxic red fluorescent protein that can be used to induce local oxidative stress by green-orange light illumination. Here we studied phototoxicity of KillerRed targeted to cytoplasmic surface of lysosomes via fusion with Rab7, a small GTPase that is known to be attached to
- PMID 24365992
- Frequent translocations of 11q13.2 and 19p13.2 in ovarian cancer.
- Wang L1, Wenners A, Hilpert F, Fredrik R, Micci F, Onkes W, Caliebe A, Maass N, Weimer J, Arnold N.Author information 1Department of Gynecology, Zhejiang University School of Medicine, The 2nd Affiliated Hospital, Hangzhou, Zhejiang, China; Clinic of Gynecology and Obstetrics, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Schleswig-Holstein, Germany.AbstractAberrations of chromosome arm 19p in ovarian cancer were first described decades ago and have been confirmed in recent publications, which have focused on chromosome 11 as a translocation partner. Recently, genetic analysis of the ovarian cancer cell line SKOV3 revealed a rearrangement described as der(19)t(11;19)(q13.2;p13.2), which lead to a fusion protein containing parts of HOOK2 and frame shifted ACTN3 that had unknown functionality. To evaluate the frequency of these breakpoints, we used fluorescence in situ hybridization (FISH) probes flanking these genes for interphase analysis of ovarian cancer cells. We analyzed 49 primary cell cultures of ovarian cancers using FISH probes next to these breakpoints on chromosomes 11 and 19 defined in SKOV3. Co-localizations of the signals in interphase nuclei were considered to be positive fusions when the frequency was over the experimentally calculated cutoff of 24.3% (mean average value for normal ovary cells plus three times the standard deviation). Fusions between 11q13.2 and 19p13.2 were confirmed in 22 (45%) primary cell cultures of ovarian cancers. However, by PCR, the fusion originally described in SKOV3 was not detected in any of the primary cell cultures. Our results confirm other reports and show that these regions are very frequently involved in chromosomal rearrangements in ovarian cancer. Furthermore, they reveal a significant correlation (P = 0.023) of co-localized signals of 11q13.2 and 19p13.2 with low and intermediate grades in ovarian cancer. © 2014 Wiley Periodicals, Inc.
- Genes, chromosomes & cancer.Genes Chromosomes Cancer.2014 Jun;53(6):447-53. doi: 10.1002/gcc.22152. Epub 2014 Feb 24.
- Aberrations of chromosome arm 19p in ovarian cancer were first described decades ago and have been confirmed in recent publications, which have focused on chromosome 11 as a translocation partner. Recently, genetic analysis of the ovarian cancer cell line SKOV3 revealed a rearrangement described as
- PMID 24615723
- Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.
- Coppieters N1, Dieriks BV2, Lill C2, Faull RL2, Curtis MA2, Dragunow M3.Author information 1Departments of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand; Gravida National Centre for Growth and Development, The University of Auckland, Auckland, New Zealand; Centre for Brain Research, The University of Auckland, Auckland, New Zealand.2Centre for Brain Research, The University of Auckland, Auckland, New Zealand; Department of Anatomy with Radiology, The University of Auckland, Auckland, New Zealand.3Departments of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand; Gravida National Centre for Growth and Development, The University of Auckland, Auckland, New Zealand; Centre for Brain Research, The University of Auckland, Auckland, New Zealand. Electronic address: m.dragunow@auckland.ac.nz.AbstractDNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA hydroxymethylation (5-hydroxymethylcytosine [5hmC]), the oxidized form of 5mC. Whereas 5mC is generally associated with the inhibition of gene expression, 5hmC has been associated with increased gene expression and is involved in cellular processes such as differentiation, development, and aging. Recent findings point toward a role for 5hmC in the development of diseases including AD, potentially opening new pathways for treating AD through correcting methylation and hydroxymethylation alterations. In the present study, levels of 5mC and 5hmC were investigated in the human middle frontal gyrus (MFG) and middle temporal gyrus (MTG) by immunohistochemistry. Immunoreactivity for 5mC and 5hmC were significantly increased in AD MFG (N = 13) and MTG (N = 29) compared with age-matched controls (MFG, N = 13 and MTG, N = 29). Global levels of 5mC and 5hmC positively correlated with each other and with markers of AD including amyloid beta, tau, and ubiquitin loads. Our results showed a global hypermethylation in the AD brain and revealed that levels of 5hmC were also significantly increased in AD MFG and MTG with no apparent influence of gender, age, postmortem delay, or tissue storage time. Using double-fluorescent immunolabeling, we found that in control and AD brains, levels of 5mC and 5hmC were low in astrocytes and microglia but were elevated in neurons. In addition, our colocalization study showed that within the same nuclei, 5mC and 5hmC mostly do not coexist. The present study clearly demonstrates the involvement of 5mC and 5hmC in AD emphasizing the need for future studies determining the exact time frame of these epigenetic changes during the progression of AD pathology.
- Neurobiology of aging.Neurobiol Aging.2014 Jun;35(6):1334-44. doi: 10.1016/j.neurobiolaging.2013.11.031. Epub 2013 Dec 4.
- DNA methylation (5-methylcytosine [5mC]) is one of several epigenetic markers altered in Alzheimer's disease (AD) brain. More recently, attention has been given to DNA hydroxymethylation (5-hydroxymethylcytosine [5hmC]), the oxidized form of 5mC. Whereas 5mC is generally associated with the inhibiti
- PMID 24387984
Japanese Journal
- Deposition of thin Si and Ge films by ballistic hot electron reduction in a solution-dripping mode and its application to the growth of thin SiGe films
- Suda Ryutaro,Yagi Mamiko,Kojima Akira,Mentek Romain,Mori Nobuya,Shirakashi Jun-ichi,Koshida Nobuyoshi
- Jpn. J. Appl. Phys. 54(4S), 04DH11, 2015-03-13
- … Ballistic hot electrons injected into solutions with appropriate kinetic energies promote preferential reduction of target ions with no by-products leading to nuclei formation for the thin film growth. …
- NAID 150000110477
- Electrochemical deposition of zinc oxide nanorods for hybrid solar cells
- Ty Jennifer,Yanagi Hisao
- Jpn. J. Appl. Phys. 54(4S), 04DK05, 2015-03-12
- … Chronoamperometric transient curves show that nucleation and coalescence occurred later for bare ITO substrates, indicating lower densities of initial nuclei, resulting in the growth of nanorods with larger diameters. …
- NAID 150000110488
- Vitrification and crystallization of poly(butylene-2,6-naphthalate)
- Nishida Koji,Zhuravlev Evgeny,Yang Bin,Schick Christoph,Shiraishi Yasuhiro,Kanaya Toshiji
- Thermochimica Acta 603, 110-115, 2015-03-10
- … The cooling rate larger than 6000 K/s could make the PBN vitrify and the cooling rate larger than 30,000 K/s reduced effectively the development of the active nuclei. …
- NAID 120005587797
Related Links
- nu·cle·i (no o′klē-ī′, nyo o′-) n. A plural of nucleus. nuclei (ˈnjuːklɪˌaɪ) n a plural of nucleus nu•cle•us (ˈnu kli əs, ˈnyu-) n., pl. -cle•i (-kliˌaɪ) -cle•us•es. 1. a central part about which other parts are grouped or gathered; core. 2. a ...
- Nuclei definition, plural of nucleus. See more. ... nucleus nu·cle·us (nōō'klē-əs, nyōō'-) n. pl. nu·cle·us·es or nu·cle·i (-klē-ī') A large, membrane-bound, usually spherical protoplasmic structure within a living cell, containing the cell's ...
Related Pictures
★リンクテーブル★
| リンク元 | 「nuclear」「nucleo」「核」 |
| 拡張検索 | 「caudate nuclei」「trigeminal nuclei」 |
「nuclear」
- adj.
- 核の、(生物)細胞核の、(物理)原子核の
「nucleo」
- comb form.
- クレオ、核の