キャップ結合タンパク質複合体
WordNet
- complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs"
- a compound described in terms of the central atom to which other atoms are bound or coordinated (同)coordination_compound
- a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" (同)composite
- (psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a persons behavior
- lie at the top of; "Snow capped the mountains" (同)crest
- a fruiting structure resembling an umbrella or a cone that forms the top of a stalked fleshy fungus such as a mushroom (同)pileus
- restrict the number or amount of; "We had to cap the number of people we can accept into our club"
- a tight-fitting headdress
- a top (as for a bottle)
- something serving as a cover or protection
- executed with proper legal authority; "a binding contract"
- the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
- strip sewn over or along an edge for reinforcement or decoration
- the capacity to attract and hold something
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 『いくつかの部分から成る』,複合の,合成の / 『複雑な』,入りくんだ,こみいった(complicated) / 複合体,合成物 / コンプレックス,複合(抑圧されて心に残った複雑なしこり)
- (縁のない)『帽子』,制帽 / (形・用途が)帽子に似たもの;万年筆のキャップ,時計の中ぶた,びんのふた,キノコのかさなど / (銃弾の)雷管;おもちゃのピストル玉 / 頂上,最高 / …‘に'帽子をかぶせる / …‘の'頂をおおう / 〈人が言った・した事〉‘の'上手(うわて)を行く,'を'しのぐ / …‘に'栄誉を与える
- 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
- 『核の』,細胞核の / [『原子』]『核の』
- 蛋白(たんばく)質
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/29 12:59:19」(JST)
[Wiki en表示]
| nuclear cap-binding protein complex |
|
Crystal structure of the human nuclear cap-binding complex.[1]
|
| Identifiers |
| Symbol |
NCBP1 |
| Alt. symbols |
NCBP |
| Entrez |
4686 |
| HUGO |
7658 |
| RefSeq |
NM_002486 |
| Other data |
| Locus |
Chr. 9 q34.1 |
| Nuclear cap binding protein subunit 2, 20kDa |
| Identifiers |
| Symbol |
NCBP2 |
| Entrez |
22916 |
| HUGO |
7659 |
| OMIM |
605133 |
| RefSeq |
NM_007362 |
| UniProt |
P52298 |
| Other data |
| Locus |
Chr. 3 q29 |
Nuclear cap-binding protein complex is a RNA-binding protein which binds to the 5' cap of pre-mRNA. The cap and nuclear cap-binding protein have many function in mRNA biogenesis including splicing, 3'-end formation by stabilizing the interaction of the 3'-end processing machinery, nuclear export and protection of the transcripts from nuclease degradation.[2] When RNA is exported to the cytoplasm the nuclear cap-binding protein complex is replaced by cytoplasmic cap binding complex. The nuclear cap-binding complex is a functional heterodimer and composed of Cbc1/Cbc2 in yeast and CBC20/CBC80 in multicellular eukaryotes. Human nuclear cap-binding protein complex shows the large subunit, CBC80 consists of 757 amino acid residues. Its secondary structure contains approximately sixty percent of helical and one percent of beta sheet in the strand. The small subunit, CBC20 has 98 amino acid residues. Its secondary structure contains approximately twenty percent of helical and twenty-four percent of beta sheet in the strand.[1] Human nuclear cap-binding protein complex plays important role in the maturation of pre-mRNA and uracil-rich small nuclear RNA.[3]
References
- ^ a b PDB 1H6K; Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S (August 2001). "Crystal structure of the human nuclear cap binding complex". Mol. Cell 8 (2): 383–96. doi:10.1016/S1097-2765(01)00299-4. PMID 11545740.
- ^ Raczynska KD, Simpson CG, Ciesiolka A, et al. (January 2010). "Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana". Nucleic Acids Res. 38 (1): 265–78. doi:10.1093/nar/gkp869. PMC 2800227. PMID 19864257.
- ^ Mazza C, Segref A, Mattaj IW, Cusack S (October 2002). "Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex". EMBO J. 21 (20): 5548–57. doi:10.1093/emboj/cdf538. PMC 129070. PMID 12374755.
External links
- nuclear cap-binding protein complex at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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- 4. 複合免疫不全 combined immunodeficiencies
- 5. 2型糖尿病の病因 pathogenesis of type 2 diabetes mellitus
English Journal
- Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20.
- Choe J, Kim KM, Park S, Lee YK, Song OK, Kim MK, Lee BG, Song HK, Kim YK.SourceSchool of Life Sciences and Biotechnology, Korea University, Seoul 136-701 and Panbionet Corporation, Pohang, Kyungbuk 790-784, Republic of Korea.
- Nucleic acids research.Nucleic Acids Res.2012 Dec 11. [Epub ahead of print]
- The translation of mammalian messenger RNAs (mRNAs) can be driven by either cap-binding proteins 80 and 20 (CBP80/20) or eukaryotic translation initiation factor (eIF)4E. Although CBP80/20-dependent translation (CT) is known to be coupled to an mRNA surveillance mechanism termed nonsense-mediated mR
- PMID 23234701
- Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA.
- Qiu ZR, Chico L, Chang J, Shuman S, Schwer B.SourceMolecular Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
- RNA (New York, N.Y.).RNA.2012 Nov;18(11):1996-2011. doi: 10.1261/rna.033746.112. Epub 2012 Sep 21.
- Nuclear cap binding protein complex (CBC) is a heterodimer of a small subunit (Cbc2 in yeast) that binds the m(7)G cap and a large subunit (Sto1 in yeast) that interacts with karyopherins. In order to probe the role of cap recognition in yeast CBC function, we introduced alanine mutations (Y24A, F91
- PMID 23002122
- The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame.
- Kim KM, Cho H, Kim YK.SourceSchool of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Republic of Korea.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2012 Aug 3;424(3):469-75. doi: 10.1016/j.bbrc.2012.06.135. Epub 2012 Jul 4.
- The first round of translation occurs on mRNAs bound by nuclear cap-binding complex (CBC), which is composed of nuclear cap-binding protein 80 and 20 (CBP80/20). During this round of translation, aberrant mRNAs are recognized and downregulated in abundance by nonsense-mediated mRNA decay (NMD), whic
- PMID 22771799
Japanese Journal
- HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment.
- Taniguchi Ichiro,Mabuchi Naoto,Ohno Mutsuhito
- Nucleic acids research 42(10), 6645-6658, 2014-04
- … Nuclear RNA export pathways in eukaryotes are often linked to the fate of a given RNA. … This issue is highlighted when the human immunodeficiency virus type 1 (HIV-1) Rev protein induces the export of singly spliced and unspliced HIV-1 transcripts. … How these RNAs are exported is not well understood because such transcripts should have the possibility of utilizing CRM1-dependent export via Rev or cellular TAP/NXF1-dependent export via the transcription/export (TREX) complex, or both. …
- NAID 120005458278
- Du3, a mRNA cap-binding protein gene, regulates amylose content in Japonica rice seeds
- , , [他], , ,
- Plant biotechnology 25(5), 483-487, 2008-12-01
- … Furthermore, map-based cloning revealed that Du3 encodes the rice homolog of a cap-binding protein 20 kD subunit (CBP20), a component of the heterodimeric nuclear cap-binding complex (CBC) playing a role in pre-mRNA splicing, RNA nuclear export, and nonsense-mediated decay. …
- NAID 10021914714
- A nuclear cap binding protein complex involved in pre-mRNA splicing
Related Links
- The nuclear cap-binding protein complex (CBC) participates in 5′ splice site selection of introns that are proximal to the mRNA cap. However, it is not known whether CBC has a role in alternative splicing. Using an RT ...
- "Nuclear Cap-Binding Protein Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... A heterodimeric protein complex of RNA cap-binding proteins, which ...
★リンクテーブル★
[★]
- 英
- nuclear cap-binding protein complex
[★]
- 関
- affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union
[★]
- 関
- complexes、complicated、composite、conjugate、intricate
[★]
[★]
- 関
- cell nuclei、cell nucleus、nuclei、nucleo、nucleus
[★]
- 関
- BP、carrier protein、transport protein