単球増加症
WordNet
- increase in the number of monocytes in the blood; symptom of monocytic leukemia
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/15 13:04:34」(JST)
[Wiki en表示]
Monocytosis |
Classification and external resources |
ICD-10 |
D72.8 |
ICD-9 |
288.8 |
DiseasesDB |
22713 |
Monocytosis is an increase in the number of monocytes circulating in the blood.[1] Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system.
In humans, 950/μL is regarded as at the upper limit of normal; monocyte counts above this level are regarded as monocytosis.[citation needed]
Causes
Monocytosis often occurs during chronic inflammation. Diseases that produce this state:
- Infections: tuberculosis, brucellosis, listeriosis, subacute bacterial endocarditis, syphilis, and other viral infections and many protozoal and rickettsial infections (e.g. kala azar, malaria, Rocky Mountain spotted fever).
- Blood and immune causes: chronic neutropenia and myeloproliferative disorders.
- Autoimmune diseases and vasculitis: systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease.
- Malignancies: Hodgkin's disease and certain leukaemias, such as chronic myelomonocytic leukaemia (CMML) and monocytic leukemia.
- Recovery phase of neutropenia or an acute infection.
- Obesity (cf. Nagareddy et al. (2014), Cell Metabolism, Vol. 19, pp 821-835)
- Miscellaneous causes: sarcoidosis and lipid storage disease.
References
- ^ "monocytosis" at Dorland's Medical Dictionary
Hematologic disease: Monocyte and granulocyte disease (CFU-GM/CFU-Baso/CFU-Eos), including immunodeficiency (D70-D71, 288)
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Monocytes/
macrophages |
↑ |
- Histiocytosis
- Chronic granulomatous disease
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-cytosis: |
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↓ |
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Granulocytes |
↑ |
-cytosis: |
- granulocytosis
- Neutrophilia
- Eosinophilia/Hypereosinophilic syndrome
- Basophilia
- Bandemia
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↓ |
-penia: |
- Granulocytopenia/agranulocytosis (Neutropenia/Kostmann syndrome
- Eosinopenia
- Basopenia)
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PBD |
chemotaxis/degranulation: |
- Leukocyte adhesion deficiency
- Chédiak–Higashi syndrome
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respiratory burst: |
- Chronic granulomatous disease
- Neutrophil immunodeficiency syndrome
- Myeloperoxidase deficiency
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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UpToDate Contents
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English Journal
- The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice.
- Fuller M1, Dadoo O1, Serkis V1, Abutouk D1, MacDonald M1, Dhingani N1, Macri J1, Igdoura SA1, Trigatti BL2.
- Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 Sep 11. pii: ATVBAHA.114.304200. [Epub ahead of print]
- OBJECTIVE: Deficiency of the high-density lipoprotein receptor, scavenger receptor class B, type I (SR-BI), in apolipoprotein E knockout or hypomorphic mice, respectively, results in spontaneous or diet-inducible occlusive coronary artery (CA) atherosclerosis, myocardial infarction, and early death.
- PMID 25212235
- mir33 Inhibition Overcomes Deleterious Effects of Diabetes on Atherosclerosis Plaque Regression in Mice.
- Distel E1, Barrett T2, Chung KW3, Girgis NM4, Parathath S5, Esau CC6, Murphy AJ7, Moore KJ8, Fisher EA9.
- Circulation research.Circ Res.2014 Sep 8. pii: CIRCRESAHA.114.304164. [Epub ahead of print]
- Rationale: Diabetes increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models diabetes impairs atherosclerosis plaque regression after aggressive cholesterol-lowering. miR33 is a key negative regulato
- PMID 25201910
- Lower Apo A-I and Lower HDL-C Levels Are Associated With Higher Intermediate CD14++CD16+ Monocyte Counts That Predict Cardiovascular Events in Chronic Kidney Disease.
- Rogacev KS1, Zawada AM2, Emrich I2, Seiler S2, Böhm M2, Fliser D2, Woollard KJ2, Heine GH2.
- Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2014 Sep;34(9):2120-7. doi: 10.1161/ATVBAHA.114.304172. Epub 2014 Jul 24.
- OBJECTIVE: Patients with chronic kidney disease (CKD) display impaired cholesterol efflux capacity and elevated CD14(++)CD16(+) monocyte counts. In mice, dysfunctional cholesterol efflux causes monocytosis. It is unknown whether cholesterol efflux capacity and monocyte subsets are associated in CKD.
- PMID 25060791
Japanese Journal
- 佐藤 敏彦,信田 卓男,圓尾 拓也,川村 裕子,山田 徹,伊藤 哲郎,武田 晴央,杉山 大樹,石川 剛司,斑目 広郎,茅沼 秀樹,菅沼 常徳
- 日本獣医がん学会雑誌 3(2), 20-24, 2012
- 人の肺癌では、腫瘍随伴症候群として好中球増加症や単球増加症を伴う白血球増加症が報告されている。しかしながら、犬では腫瘍随伴性白血球増加症の報告は少ない。今回、初診時の血液検査にて好中球を主体とした白血球増加症を示した犬に対し、種々の検査を行った結果、巨大肺腫瘤を認め、肺腫瘤の摘出術を行った。術後の病理組織学的検査にて肺腺癌と診断されたが、腫瘍の摘出とともに劇的な好中球数の回復がみられ、肺癌による腫 …
- NAID 130003303180
- 天野 浩文
- 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 34(1), 1-7, 2011-02-28
- 全身性エリテマトーデス(SLE)をはじめとする全身性の自己免疫疾患では,IgGクラスの自己抗体の産生及び免疫複合体形成に伴う組織障害がその病態形成に重要である.IgG型Fcγレセプター(FcγR)は,IgGのFc部分を認識し,沈着する免疫複合体に対する免疫応答にとって重要な役割を担っている.さらにFcγRは,抗原と複合体を形成したIgGと結合したのち,活性型FcγRと抑制型FcγRであるFcγ …
- NAID 10029431513
- Therapy-related Myelodysplastic/myeloproliferative Neoplasms with del(5q) and t(1;11)(p32;q23) Lacking MLL Rearrangement
- Yamamoto Katsuya,Katayama Yoshio,Shimoyama Manabu,Matsui Toshimitsu
- Internal Medicine 49(11), 1031-1035, 2010
- … A 69-year-old man was admitted because of macrocytic anemia and peripheral monocytosis: hemoglobin 75 g/L and white blood cells 16.0×109 /L with 22% monocytes. …
- NAID 130000251584
Related Links
- Definition of monocytosis in the Medical Dictionary. monocytosis explanation. Information about monocytosis in Free online English dictionary. What is monocytosis? Meaning of monocytosis medical term. What does forum ? ...
- monocytosis mon·o·cy·to·sis (mŏn'ə-sī-tō'sĭs) n. An abnormal increase in the number of monocytes in the blood, occurring in infectious mononucleosis and ... Browse more topics on our blog What Is the Difference Between Discreet ...
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- 英
- monocytosis
- 同
- 単球増多症
- 関
- 単球
定義
- 末梢血単球数が950/μLを超えた状態。
- 分画が7%以上、末梢血で1000μL以上(臨床検査データブック2017-2018)
増加するメカニズム
- 単球が腫瘍性に増加する
- 単球の貪食が盛んになる病態で増加する(病原体や病原体に侵入された細胞、ないし組織崩壊物が貪食される)。
鑑別疾患