English Journal
- Orbital lymphoma mimicking ophthalmopathy in a patient with graves'.
- Moura Neto A, Denardi FC, Delamain MT, Tambascia MA, Vassallo J, Caldato R, Zantut-Wittmann DE.SourceDivision of Endocrinology (AMN, FCD, MAT, DEZW), Division of Hematology (MAD), Department of Internal Medicine; Department of Anatomical Pathology (JV); and Department of Ophthalmology (RC), University of Campinas, Campinas, São Paulo, Brazil.
- The American journal of the medical sciences.Am J Med Sci.2012 Nov;344(5):418-21. doi: 10.1097/MAJ.0b013e3182582330.
- ABSTRACT:: The objective of this case report is to present a rare association of a mucosa-associated lymphoid tissue lymphoma masquerading as Graves' orbitopathy in a patient with autoimmune hyperthyroidism, without evidence of Graves' ophthalmopathy. A 66-year-old male patient had pain and swelling
- PMID 22885624
- Hypothyroidism improves random-pattern skin flap survival in rats.
- Rahimpour S, Nezami BG, Karimian N, Sotoudeh-Anvari M, Ebrahimi F, Taleb S, Mirazi N, Dehpour AR.SourceDepartment of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
- The Journal of surgical research.J Surg Res.2012 Nov;178(1):524-8. doi: 10.1016/j.jss.2012.03.058. Epub 2012 Apr 14.
- BACKGROUND: The protective effect of hypothyroidism against ischemic or toxic conditions has been shown in various tissues. We investigated the effect of propylthiouracil (PTU)/methimazole (MMI)-induced hypothyroidism and acute local effect of MMI on the outcome of lethal ischemia in random-pattern
- PMID 22521221
Japanese Journal
- The Relation of Initial Methimazole Dose to the Incidence of Methimazole-induced Agranulocytosis in Patients with Graves' Disease
- TSUBOI KUMIKO,UESHIBA HAJIME,SHIMOJO MASAKO,ISHIKAWA MAYUMI,WATANABE NATSUKO,NAGASAWA KAORU,YUASA RENA,YOSHINO GEN
- Endocrine journal 54(1), 39-43, 2007-02-20
- NAID 10019479202
- Hyperthyroidism Complicated With Sick Sinus Syndrome
- Namura Masanobu,Kanaya Hohnin,lkeda Masatoshi,Shibayama Shinsuke,Ohka Takio
- Japanese circulation journal 59(12), 824-828, 1995-11-20
- … After a euthyroid state was successively induced for about 10 days by methylmercaptoimidazole therapy, AH-time, HV-time and CSRT were shortened to 85, 35 and 290 msec respectively. …
- NAID 110002607263
- A Hyperthyroid Patient with Graves' Disease Who Was Strongly Resistant to Methimazole : Investigation on Possible Mechanisms of the Resistance
- LI Hua,OKUDA Jyoji,AKAMIZU Takashi,MORI Toru
- Endocrine journal 42(5), 697-704, 1995-10-01
- NAID 10008462972
Related Links
- Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the sy... Pharmacy Codes — all pharmacy codes and search Methylmercaptoimidazole Category Antithyroid Agents ATC:H03B
- Methylmercaptoimidazole - chemical information, properties, structures, articles, patents and more chemical data. Enter your search term above and find: · CAS Numbers · Molecular Formulas · Synonyms · Sites/Web Search · Suppliers
Related Pictures
★リンクテーブル★
| リンク元 | 「抗甲状腺薬」 |
「抗甲状腺薬」
種類
- チアミド系の化合物が用いられる(SPC.323)
作用機序
- 甲状濾胞内に能動的に取り込まれ、濾胞内でヨードの有機化と縮合を抑制
- 甲状腺濾胞内に浸潤しているリンパ球の自己抗体産生を抑制
副作用
- チアミド系化合物の副作用
副作用に対する対処
- 症状：突然の咽頭痛、発熱
- 処置：
- 抗甲状腺薬の中止。副腎皮質ホルモン、抗菌薬、輸血、G-CSF (医学辞書改変)
- 無顆粒球症(好中球＜500/ul)と判断されたらすぐに抗甲状腺薬の中止。
薬物動態の比較
- 文献不明
| チアマゾール thiamazole メチマゾール methimazole methylmercaptoimidazole MMI |
プロピルチオウラシル PTU | |
| 商品名 | メルカゾール(5mg/錠) | プロパジール(50mg/錠) |
| 薬効 | 13-14 | 1 |
| 初回量 | 30-45 mg | 300-600 mg |
| 維持量 | 5-10 mg | 50-200 mg |
| 血中半減期 | 約6時間 | 約2.5時間 |
| 作用持続時間 | 24時間 | 4-8時間 |
| 吸収 | ほぼ100% | ほぼ100% |
| アルブミン結合 | 5%以下 | 約80% |
| 末梢作用 | なし | T4→T3への変換を抑制 |
| 作用発現(T4正常化) | 1-2ヶ月 | 2-3ヶ月 |
| 胎盤移行 | 多い | 少ない |
| 乳汁移行 | 多い | ほとんどなし |
| 尿中排泄 | 48時間で約70% | 24時間で約80% |
| 肝・腎不全時 | 代謝不変 | 代謝低下 |
- SPC.1528
| チアマゾール | プロピルチオウラシル | |
| 血漿タンパクとの結合 | 結合しない | 0.75 |
| 血漿半減期 | 4?6時間 | 75分 |
| 分布容積 | 40 liters | 20 liters |
| 甲状腺での濃縮 | 濃縮 | 濃縮 |
| 重症な肝臓病患者での代謝 | 減少 | 普通 |
| 重症な腎臓病患者での代謝 | 普通 | 普通 |
| 投与頻度 | 1-2回/日 | 1-4回/日 |
| 胎盤の通過 | 低 | 低 |
| 母乳への移行 | 低 | 低 |