マトリックスメタロプロテアーゼ3
WordNet
- (geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
- mold used in the production of phonograph records, type, or other relief surface
- the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
- (mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
- an enclosure within which something originates or develops (from the Latin for womb)
- the formative tissue at the base of a nail
PrepTutorEJDIC
- （複数形 matrices, ～・es）(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文 （matrix sentence）
- マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)
UpToDate Contents
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English Journal
- Comparison of golimumab 100-mg monotherapy to golimumab 50 mg plus methotrexate in patients with rheumatoid arthritis: Results from a multicenter, cohort study.
- Yonemoto Y1, Okamura K, Takeuchi K, Ayabe K, Kaneko T, Matsushita M, Tamura Y, Iso T, Okura C, Otsuka K, Inoue H, Takagishi K.
- Modern rheumatology / the Japan Rheumatism Association.Mod Rheumatol.2015 Aug 3:1-5. [Epub ahead of print]
- OBJECTIVE: The aim of this study was to compare the efficacy and safety of golimumab (GLM) 50 mg + methotrexate (MTX) combination therapy and GLM 100 mg monotherapy in patients with rheumatoid arthritis (RA).METHODS: The subjects were 115 RA patients (92 females and 23 males; median (range) age, 6
- PMID 26140464
- Positive association between serum thymic stromal lymphopoietin and anti-citrullinated peptide antibodies in patients with rheumatoid arthritis.
- Koyama K1, Ohba T1, Haro H1, Nakao A2.
- Clinical and experimental immunology.Clin Exp Immunol.2015 Aug;181(2):239-43. doi: 10.1111/cei.12632.
- Thymic stromal lymphopoietin (TSLP) has been suggested recently to play an important role in the pathophysiology of rheumatoid arthritis (RA). However, there is little information on serum TSLP concentrations in RA and its clinical significance. The present study investigated whether serum TSLP conc
- PMID 25817699
- Decorin-expressing adenovirus decreases collagen synthesis and upregulates MMP expression in keloid fibroblasts and keloid spheroids.
- Lee WJ1, Ahn HM2, Roh H1, Na Y2, Choi IK2, Lee JH3, Kim YO1, Lew DH1, Yun CO2.
- Experimental dermatology.Exp Dermatol.2015 Aug;24(8):591-7. doi: 10.1111/exd.12719. Epub 2015 May 8.
- Decorin is a natural transforming growth factor-β1 (TGF-β1) antagonist. Reduced decorin synthesis is associated with dermal scarring, and increased decorin expression appears to reduce scar tissue formation. To investigate the therapeutic potential of decorin for keloids, human dermal fibroblasts
- PMID 25865370
Japanese Journal
- 森林浴を体験したリウマチ患者の血清ヒドロペルオキシド,MMP-3,尿中8-OHdG,唾液イムノグロブリンA量に関する調査
- 菅谷 茂,綛谷 珠美,紀 仲秋 [他]
- 千葉医学雑誌 87(5), 181-188, 2011-10
- … The amounts of serum matrix metalloproteinase-3 (MMP-3), as estimated by an ELISA method, decreased after forest walking.These results were concordant with the notion for the suppression of oxidative stress and modulation of immunological and/or enzymatic physiological functions by forest walking. …
- NAID 40019039315
- 生物学的製剤による治療で寛解導入後投与中止となった関節リウマチ患者の検討 (第23回日本臨床整形外科学会学術集会)
Related Links
- matrix metalloproteinase 3 matrix metalloproteinase 3 An enzyme encoded on chromosome 11q22.3 which degrades various tissue substrates (e.g., collagens and others). Cytokine inducers EGF, CD40L, EGF, FGF-a, FGF-b, FGF ...
- TEXT Description Human fibroblast stromelysin (also called transin or matrix metalloproteinase-3) is a proteoglycanase closely related to collagenase (MMP1; 120353) with a wide range of substrate specificities. It is a secreted ...
★リンクテーブル★
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[正答]
※国試ナビ4※ ［104I014］←［国試_104］→［104I016］
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- 英
- matrix metalloproteinase 3, matrix metalloproteinase-3, MMP-3
- 関
- マトリックスメタロプロテアーゼ
概念
- OLM.402
- 活性中心にZnイオンを有する蛋白質で、細胞マトリックスを分解する
- 関節の主に滑膜細胞、一部軟骨細胞などからも産生される。
- 抗CCP抗体と並んで早期RAの診断と経過観察に役立つマーカーとして用いられる。
MMP-3の機能
- OLM.402
- 軟骨の主要成分であるプロテオグリカンを中心にコラーゲン、エラスチンなどを分解し、結合組織の分解、再生に重要な役割を果たす。
- pro MMP-1やpro MMP-9などのマトリックスメタロプロテアーゼの前駆体を活性型に変換し、細胞外マトリックスの分解を促進する。
- MMP-3の活性は滑膜細胞がから放出されるTIMP(tissue inhibitor of metalloproteinase)により抑制を受けている。
MMP-3と疾患
- OLM.402
- 滑膜細胞の増殖能を反映して増加する。 ← 滑膜細胞から分泌されるから。
- 血中のMMP-3は腎臓より排泄されるので、腎機能低下により血中MMP-3濃度が増加する。
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マトリックスメタロプロテアーゼ3 matrix metalloproteinase-3
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マトリックスメタロプロテアーゼ MMP
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メタロプロテアーゼ
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メタロプロテアーゼ