マトリックスメタロプロテアーゼ3
WordNet
- (geology) amass of fine-grained rock in which fossils, crystals, or gems are embedded
- mold used in the production of phonograph records, type, or other relief surface
- the body substance in which tissue cells are embedded (同)intercellular substance, ground_substance
- (mathematics) a rectangular array of quantities or expressions set out by rows and columns; treated as a single element and manipulated according to rules
- an enclosure within which something originates or develops (from the Latin for womb)
- the formative tissue at the base of a nail
PrepTutorEJDIC
- （複数形 matrices, ～・es）(発生・成長の)母体 / 鋳型・模型;(レコードの)原盤;(活字の)母型,字母 / (金属・化石・宝石などの含んだ)母岩・《古》子宮・基盤; (細胞)細胞間質; (地学)基質; (印)字母; 紙型; 鋳型; (鉱)母岩; (数)行列; (コンピュータ)マトリックス (入力導線と出力導線の回路網); (言)母型文 （matrix sentence）
- マトリクシング(4チャンネルに再生転換できる2チャンネルの録音方式)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/11 17:47:30」(JST)
[Wiki en表示]
| Stromelysin 1 |
| Identifiers |
| EC number |
3.4.24.17 |
| CAS number |
79955-99-0 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Stromelysin 1 (EC 3.4.24.17, matrix metalloproteinase 3, proteoglycanase, collagenase activating protein, procollagenase activator, transin, MMP-3, neutral proteoglycanase, stromelysin, collagen-activating protein) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Preferential cleavage where P1', P2' and P3' are hydrophobic residues
This extracellular endopeptidase is present in vertebrate tissues.
References
- ^ Chin, J.R., Murphy, G. and Werb, Z. (1985). "Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates". J. Biol. Chem. 260: 12367–12376. PMID 2995374.
- ^ Okada, Y., Nagase, H. and Harris, E.D., Jr. (1986). "A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization". J. Biol. Chem. 261: 14245–14255. PMID 3095317.
- ^ Docherty, A.J.P. and Murphy, G. (1990). "The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins". Ann. Rheum. Dis. 49: 469–479. PMID 2197998.
- ^ Emonard, H. and Grimaud, J.-A. (1990). "Matrix metalloproteinase. A review". Cell. Mol. Biol. 36: 131–153. PMID 2165861.
External links
- Stromelysin 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis.
- Murota A1, Suzuki K2, Kassai Y3, Miyazaki T4, Morita R5, Kondo Y6, Takeshita M7, Niki Y8, Yoshimura A9, Takeuchi T10.
- Cytokine.Cytokine.2016 Feb;78:87-93. doi: 10.1016/j.cyto.2015.12.002. Epub 2015 Dec 14.
- OBJECTIVES: To conduct a comprehensive quantitative proteomics analysis of novel serum protein biomarkers based on synovitis status associated with matrix metalloproteinase-3 (MMP-3) and to determine the clinical significance of these biomarkers in rheumatoid arthritis (RA).METHODS: Patients with un
- PMID 26700586
- Matrix Metalloproteinase 3 Gene Polymorphism and Its Level Predict Morbidity After Acute Myocardial Infarction.
- El-Aziz TA1, Mohamed RH2.
- American journal of clinical pathology.Am J Clin Pathol.2016 Jan;145(1):134-9. doi: 10.1093/ajcp/aqv008.
- OBJECTIVES: Matrix metalloproteinase is responsible for ventricular remodeling after acute myocardial infarction (MI). The purpose of the present study was to determine whether the matrix metalloproteinase 3 (MMP-3) polymorphism and its level predict morbidity after acute MI (AMI).METHODS: We studie
- PMID 26712881
- Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis.
- van den Bosch MH1, Blom AB1, Schelbergen RF1, Vogl T2, Roth JP2, Slöetjes AW1, van den Berg WB1, van der Kraan PM1, van Lent PL1.
- Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2016 Jan;68(1):152-63. doi: 10.1002/art.39420.
- OBJECTIVE: Both alarmins S100A8/A9 and canonical Wnt signaling have been found to play active roles in the development of experimental osteoarthritis (OA). However, what activates canonical Wnt signaling remains unknown. This study was undertaken to investigate whether S100A8 induces canonical Wnt s
- PMID 26360647
Japanese Journal
- Biologic Therapy Suppresses Subclinical Inflammation Identified by Magnetic Resonance Imaging in Rheumatoid Arthritis Patients in Clinical Remission State
- Hasui Keisuke,Sakuraba Hirotake,Ishiguro Yoh,Hiraga Hiroto,Fukuda Shinsaku
- 弘前医学 64(2-4), 119-126, 2014-02-28
- … There were no significant differences in DAS28-ESR, Simplified Disease activity Index（SDAI）, and Matrix Metalloproteinase（MMP）-3 between the biologics group and the nonbiologics group at clinical remission. …
- NAID 120005398075
- Proteolytic and Non-proteolytic Activation of Keratinocyte-Derived Latent TGF-β1 Induces Fibroblast Differentiation in a Wound-Healing Model Using Rat Skin
- Hata Shozaburo,Okamura Kazuhiko,Hatta Mitsutoki [他]
- Journal of pharmacological sciences 124(2), 230-243, 2014-02
- NAID 40019992646
- In Vitro Evaluation of Inhibitory Effect of Nuclear Factor-KappaB Activity by Small Interfering RNA on Pro-tumor Characteristics of M2-Like Macrophages
- Kono Yusuke,Kawakami Shigeru,Higuchi Yuriko,Yamashita Fumiyoshi,Hashida Mitsuru
- Biological and Pharmaceutical Bulletin 37(1), 137-144, 2014-01-01
- … Furthermore, vascular endothelial growth factor production and matrix metalloproteinase-9 mRNA expression in M2-like macrophages were suppressed by inhibition of NF-κB expression with NF-κB (p50) siRNA. …
- NAID 120005394590
Related Links
- マトリックスメタロプロテアーゼ-3, Matrix Metalloproteinase-3（MMP-3） 平成19年12月17日より院内実施 外注会社：BML（平成15年4月1日より平成19年12月14日まで） 大塚（平成15年3月31日まで） 臨床的意義 ...
- matrix metalloproteinase 3 An enzyme encoded on chromosome 11q22.3 which degrades various tissue substrates (e.g., collagens and others). Cytokine inducers EGF, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF ...
★リンクテーブル★
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- 英
- matrix metalloproteinase 3, matrix metalloproteinase-3, MMP-3
- 関
- マトリックスメタロプロテアーゼ
概念
- OLM.402
- 活性中心にZnイオンを有する蛋白質で、細胞マトリックスを分解する
- 関節の主に滑膜細胞、一部軟骨細胞などからも産生される。
- 抗CCP抗体と並んで早期RAの診断と経過観察に役立つマーカーとして用いられる。
MMP-3の機能
- OLM.402
- 軟骨の主要成分であるプロテオグリカンを中心にコラーゲン、エラスチンなどを分解し、結合組織の分解、再生に重要な役割を果たす。
- pro MMP-1やpro MMP-9などのマトリックスメタロプロテアーゼの前駆体を活性型に変換し、細胞外マトリックスの分解を促進する。
- MMP-3の活性は滑膜細胞がから放出されるTIMP(tissue inhibitor of metalloproteinase)により抑制を受けている。
MMP-3と疾患
- OLM.402
- 滑膜細胞の増殖能を反映して増加する。 ← 滑膜細胞から分泌されるから。
- 血中のMMP-3は腎臓より排泄されるので、腎機能低下により血中MMP-3濃度が増加する。
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ストロメライシン
- 関
- matrix metalloproteinase 3
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マトリックスメタロプロテアーゼ3
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マトリックスメタロプロテアーゼ MMP
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メタロプロテアーゼ
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メタロプロテアーゼ