リ・キシゲナーゼ阻害薬、リ・キシゲナーゼ阻害剤

WordNet

limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
limit the range or extent of; "Contact between the young was inhibited by strict social customs"
a substance that retards or stops an activity

PrepTutorEJDIC

〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/15 20:26:18」(JST)

wiki en

A Lipoxygenase inhibitor is a drug that slows down or stops the action of the lipoxygenase enzyme. The term is almost always used to describe an inhibitor of the arachidonate 5-lipoxygenase enzyme, which transforms EFAs into leukotrienes.

Examples include:

azelastine
diethylcarbamazine
nordihydroguaiaretic acid
zileuton

External links [edit]

Lipoxygenase inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH)
MeSH list of agents 82016859

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
2. アスピリンによる呼吸器疾患の増悪 aspirin exacerbated respiratory disease
3. 思春期および成人における重症喘息の治療 treatment of severe asthma in adolescents and adults
4. 思春期および成人における中等度持続型喘息の治療 treatment of moderate persistent asthma in adolescents and adults
5. 喘息のマネージメントの概要 an overview of asthma management

English Journal

15-Lipoxygenases regulate the production of chemokines in human lung macrophages.

Abrial C1,2, Grassin-Delyle S1,2, Salvator H1,2, Brollo M1, Naline E1,2, Devillier P1,2.
British journal of pharmacology.Br J Pharmacol.2015 Sep;172(17):4319-30. doi: 10.1111/bph.13210. Epub 2015 Jul 14.
BACKGROUND AND PURPOSE: 15-Lipoxygenase (15-LOX) activity is associated with inflammation and immune regulation. The objectives of the present study were to investigate the expression of 15-LOX-1 and 15-LOX-2 and evaluate the enzymes' roles in the polarization of human lung macrophages (LMs) in resp
PMID 26040494

Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer.

Zick SM1,2, Turgeon DK3, Ren J1, Ruffin MT1, Wright BD1, Sen A1, Djuric Z1,2, Brenner DE3,4,5.
Molecular carcinogenesis.Mol Carcinog.2015 Sep;54(9):908-15. doi: 10.1002/mc.22163. Epub 2014 Apr 24.
Colorectal cancer (CRC) remains a significant cause of mortality. Inhibitors of cyclooxygenase (COX) and thus prostaglandin E2, are promising CRC preventives, but have significant toxicities. Ginger has been shown to inhibit COX, to decrease the incidence and multiplicity of adenomas, and decrease P
PMID 24760534

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.

De Lucia D1, Lucio OM2, Musio B3, Bender A4, Listing M5, Dennhardt S6, Koeberle A7, Garscha U8, Rizzo R9, Manfredini S10, Werz O11, Ley SV12.
European journal of medicinal chemistry.Eur J Med Chem.2015 Aug 28;101:573-83. doi: 10.1016/j.ejmech.2015.07.011. Epub 2015 Jul 15.
In this work the synthesis, structure-activity relationship (SAR) and biological evaluation of a novel series of triazole-containing 5-lipoxygenase (5-LO) inhibitors are described. The use of structure-guided drug design techniques provided compounds that demonstrated excellent 5-LO inhibition with
PMID 26197161

Japanese Journal

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

Liu Yang,Wang Wei,Li Yuyao [他],Xiao Yunqi,Cheng Jian,Jia Jia
Biological and Pharmaceutical Bulletin 38(8), 1234-1239, 2015
… 5-Lipoxygenase (5-LOX) inhibitors have been shown to be protective in several neurodegenerative disease models; … We investigated whether 5-LOX inhibitor zileuton conferred direct neuroprotection against glutamate oxidative toxicity by inhibiting ferroptosis, a newly identified iron-dependent programmed cell death. …
NAID 130005090655

Synthesis and Biological Evaluation of N-Aryl-5-aryloxazol-2-amine Derivatives as 5-Lipoxygenase Inhibitors

Suh Jee Hee,Yum Eul Kgun,Cho Young Sik
Chemical and Pharmaceutical Bulletin 63(8), 573-578, 2015
… We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammation-related diseases including asthma and rheumatoid arthritis. … As a result, derivatives selected through first-round screening were further optimized using a cell-based assay and an in vivo assay to develop a potent, selective 5-LOX inhibitor. …
NAID 130005090106

Synthesis and Biological Evaluation of N-Aryl-5-Aryloxazol-2-Amine Derivatives as 5-Lipoxygenase Inhibitors

Suh Jee Hee,Yum Eul Kgun,Cho Young Sik
Chemical and Pharmaceutical Bulletin advpub(0), 2015
… We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammation-related diseases including asthma and rheumatoid arthritis. … As a result, derivatives selected through first-round screening were further optimized using a cell-based assay and an in vivo assay to develop a potent, selective 5-LOX inhibitor. …
NAID 130005074310