WordNet
- limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
- control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
- limit the range or extent of; "Contact between the young was inhibited by strict social customs"
- a substance that retards or stops an activity
PrepTutorEJDIC
- 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
- 抑制する人(物) / 化学反応抑制剤
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/15 20:26:18」(JST)
[Wiki en表示]
A Lipoxygenase inhibitor is a drug that slows down or stops the action of the lipoxygenase enzyme. The term is almost always used to describe an inhibitor of the arachidonate 5-lipoxygenase enzyme, which transforms EFAs into leukotrienes.
Examples include:
- azelastine
- diethylcarbamazine
- nordihydroguaiaretic acid
- zileuton
External links [edit]
- Lipoxygenase inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH)
- MeSH list of agents 82016859
Pharmacology: enzyme inhibition
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|
Class |
- Competitive inhibition
- Uncompetitive inhibition
- Non-competitive inhibition
- Suicide inhibition
- Mixed inhibition
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|
Substrate |
Oxidoreductase (EC 1) |
- 1.1 Aldose reductase
- HMG-CoA reductase
- 1.5 Dihydrofolate reductase
- 1.17 Xanthine oxidase
- Ribonucleotide reductase
|
|
Transferase (EC 2) |
- 2.1 COMT
- Thymidylate synthase
- 2.5 Dihydropteroate synthetase
- Farnesyltransferase
- 2.7 Nucleotidyltransferase
- Integrase
- Reverse transcriptase
- Protein kinase
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|
Hydrolase (EC 3) |
- 3.1 Phosphodiesterase
- Acetylcholinesterase
- Ribonuclease
- 3.2 Polygalacturonase
- Neuraminidase
- Alpha-glucosidase
- 3.4 Protease: Exopeptidase
- Dipeptidyl peptidase-4
- ACE
- Endopeptidase
- Trypsin
- Renin
- Matrix metalloproteinase
- 3.5 Histone deacetylase
- Beta-lactamase
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|
Lyase (EC 4) |
|
|
|
Drugs for obstructive airway diseases: asthma/COPD (R03)
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|
Adrenergics, inhalants |
Short acting β2-agonists |
- Bitolterol
- Carbuterol
- Fenoterol
- Pirbuterol
- Procaterol
- Reproterol
- Rimiterol
- Salbutamol#/Levosalbutamol
- Terbutaline
- Tulobuterol
|
|
Long acting β2-agonists (LABA) |
- Arformoterol
- Bambuterol
- Clenbuterol
- Formoterol
- Olodaterol
- Salmeterol
- Ultra LABA: Indacaterol
|
|
other |
- Epinephrine#
- Hexoprenaline
- Isoprenaline (Isoproterenol)
- Orciprenaline (Metaproterenol)
|
|
|
Glucocorticoids |
- Beclometasone#
- Betamethasone
- Budesonide
- Ciclesonide
- Flunisolide
- Fluticasone
- Mometasone
- Triamcinolone
|
|
Anticholinergics/
muscarinic antagonist |
- Aclidinium bromide
- Glycopyrronium bromide
- Ipratropium bromide#
- Oxitropium bromide
- Tiotropium bromide
|
|
Mast cell stabilizers |
|
|
Xanthines |
- Doxofylline
- Enprofylline
- Theobromine
- Theophylline/Aminophylline/Choline theophyllinate
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|
Eicosanoid inhibition |
Leukotriene antagonists |
- Montelukast
- Pranlukast
- Zafirlukast
|
|
Lipoxygenase inhibitor |
|
|
Thromboxane receptor antagonists |
|
|
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Combination products |
- Budesonide/formoterol
- Fluticasone/salmeterol
- Ipratropium bromide/salbutamol
- Mometasone/formoterol
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
anat (n, x, l, c)/phys/devp
|
noco (c, p)/cong/tumr, sysi/epon, injr
|
proc, drug (R1/2/3/5/6/7)
|
|
|
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UpToDate Contents
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English Journal
- 15-Lipoxygenases regulate the production of chemokines in human lung macrophages.
- Abrial C1,2, Grassin-Delyle S1,2, Salvator H1,2, Brollo M1, Naline E1,2, Devillier P1,2.
- British journal of pharmacology.Br J Pharmacol.2015 Sep;172(17):4319-30. doi: 10.1111/bph.13210. Epub 2015 Jul 14.
- BACKGROUND AND PURPOSE: 15-Lipoxygenase (15-LOX) activity is associated with inflammation and immune regulation. The objectives of the present study were to investigate the expression of 15-LOX-1 and 15-LOX-2 and evaluate the enzymes' roles in the polarization of human lung macrophages (LMs) in resp
- PMID 26040494
- Pilot clinical study of the effects of ginger root extract on eicosanoids in colonic mucosa of subjects at increased risk for colorectal cancer.
- Zick SM1,2, Turgeon DK3, Ren J1, Ruffin MT1, Wright BD1, Sen A1, Djuric Z1,2, Brenner DE3,4,5.
- Molecular carcinogenesis.Mol Carcinog.2015 Sep;54(9):908-15. doi: 10.1002/mc.22163. Epub 2014 Apr 24.
- Colorectal cancer (CRC) remains a significant cause of mortality. Inhibitors of cyclooxygenase (COX) and thus prostaglandin E2, are promising CRC preventives, but have significant toxicities. Ginger has been shown to inhibit COX, to decrease the incidence and multiplicity of adenomas, and decrease P
- PMID 24760534
- Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.
- De Lucia D1, Lucio OM2, Musio B3, Bender A4, Listing M5, Dennhardt S6, Koeberle A7, Garscha U8, Rizzo R9, Manfredini S10, Werz O11, Ley SV12.
- European journal of medicinal chemistry.Eur J Med Chem.2015 Aug 28;101:573-83. doi: 10.1016/j.ejmech.2015.07.011. Epub 2015 Jul 15.
- In this work the synthesis, structure-activity relationship (SAR) and biological evaluation of a novel series of triazole-containing 5-lipoxygenase (5-LO) inhibitors are described. The use of structure-guided drug design techniques provided compounds that demonstrated excellent 5-LO inhibition with
- PMID 26197161
Japanese Journal
- The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis
- Liu Yang,Wang Wei,Li Yuyao [他],Xiao Yunqi,Cheng Jian,Jia Jia
- Biological and Pharmaceutical Bulletin 38(8), 1234-1239, 2015
- … 5-Lipoxygenase (5-LOX) inhibitors have been shown to be protective in several neurodegenerative disease models; … We investigated whether 5-LOX inhibitor zileuton conferred direct neuroprotection against glutamate oxidative toxicity by inhibiting ferroptosis, a newly identified iron-dependent programmed cell death. …
- NAID 130005090655
- Synthesis and Biological Evaluation of N-Aryl-5-aryloxazol-2-amine Derivatives as 5-Lipoxygenase Inhibitors
- Suh Jee Hee,Yum Eul Kgun,Cho Young Sik
- Chemical and Pharmaceutical Bulletin 63(8), 573-578, 2015
- … We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammation-related diseases including asthma and rheumatoid arthritis. … As a result, derivatives selected through first-round screening were further optimized using a cell-based assay and an in vivo assay to develop a potent, selective 5-LOX inhibitor. …
- NAID 130005090106
- Synthesis and Biological Evaluation of N-Aryl-5-Aryloxazol-2-Amine Derivatives as 5-Lipoxygenase Inhibitors
- Suh Jee Hee,Yum Eul Kgun,Cho Young Sik
- Chemical and Pharmaceutical Bulletin advpub(0), 2015
- … We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammation-related diseases including asthma and rheumatoid arthritis. … As a result, derivatives selected through first-round screening were further optimized using a cell-based assay and an in vivo assay to develop a potent, selective 5-LOX inhibitor. …
- NAID 130005074310
Related Links
- 12-Lipoxygenase inhibitor 12リポキシゲナーゼ阻害剤 15-Lipoxygenase inhibitor 15リポキシゲナーゼ阻害剤 3-Ketosteroid reductase inhibitor 3ケトステロイド-還元酵素阻害剤 5-alpha-reductase inhibitor 5-Alpha-還元酵素阻害剤 5 ...
- Network Download Search E.g: English grammar, Ethical hacking Lipoxygenase inhibitor Lipoxygenase (LOX) Inhibitors Book 5.91 MB | Ebook Pages: 154 Calbiochem • Inhibitor SourceBook 9 Lipid Signaling ...
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★リンクテーブル★
[★]
- 英
- lipoxygenase inhibitor
- 関
- リポキシゲナーゼ阻害薬
[★]
- 英
- lipoxygenase inhibitor
- 関
- リポキシゲナーゼ阻害剤
[★]
- 関
- abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression
[★]
- 関
- blocker、depressant、suppressant
[★]
リポキシゲナーゼ, 不飽和脂肪酸酸化酵素, LOX