肝星細胞
- 関
- HSC
WordNet
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- pertaining to or affecting the liver; "hepatic ducts"; "hepatic cirrhosis"
PrepTutorEJDIC
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 肝臓の;肝臓にきく,肝臓のような色の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/11 02:55:52」(JST)
[Wiki en表示]
Not to be confused with Hematopoietic stem cells, which also use the acronym HSC.
| Hepatic stellate cell |
|
Schematic presentation of hepatic stellate cells (HSC) located in the vicinity of adjacent hepatocytes (PC) beneath the sinusoidal endothelial cells (EC). S – liver sinusoids; KC – Kupffer cells. Down left shows cultured HSC at light-microscopy, whereas at down right electron microscopy (EM) illustrates numerous fat vacuoles (L) in a HSC, in which retinoids are stored.
|
|
Basic liver structure
|
| Details |
| Identifiers |
| Latin |
cellula perisinusoidalis; cellula accumulans adipem |
| Code |
TH H3.04.05.0.00013 |
| Anatomical terminology
[edit on Wikidata]
|
Hepatic stellate cells (here HSC), also known as perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes). The stellate cell is the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage.
Contents
- 1 Staining
- 2 Function
- 3 Eponym
- 4 See also
- 5 References
- 6 External links
Staining
Hepatic stellate cells can be selectively stained with gold chloride, but their distinguishing feature in routine histological preparations is the presence of multiple lipid droplets in their cytoplasm.[1] Cytoglobin expression has been shown to be a specific marker with which hepatic stellate cells can be distinguished from portal myofibroblasts in the damaged human liver.[2] In murine liver, Reelin expressed by Ito cells has been shown to be a reliable marker in discerning them from other myofibroblasts.[3] The expression of reelin is increased after liver injury.
Function
In normal liver, stellate cells are described as being in a quiescent state. Quiescent stellate cells represent 5-8% of the total number of liver cells.[4] Each cell has several long protrusions that extend from the cell body and wrap around the sinusoids. The lipid droplets in the cell body store vitamin A as retinol ester. The function and role of quiescent hepatic stellate cells is unclear. Recent evidence suggests a role as a liver-resident antigen-presenting cell, presenting lipid antigens to and stimulating proliferation of NKT cells.[5]
When the liver is damaged, stellate cells can change into an activated state. The activated stellate cell is characterized by proliferation, contractility, and chemotaxis. The amount of stored vitamin A decreases progressively in liver injury.[1] The activated stellate cell is also responsible for secreting collagen scar tissue, which can lead to cirrhosis.[6] More recent studies have also shown that in vivo activation of hepatic stellate cells by agents causing liver fibrosis can eventually lead to senescence of these cells, marked by increased SA-beta-galactosidase staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. The senescent hepatic stellate cells have been demonstrated to limit liver fibrosis by activating the immune system by activating interactions with the NK cells.[7]
Eponym
The cells of Ito were named for Toshio Ito, a twentieth-century Japanese physician.[8]
See also
- Pancreatic stellate cell
- Stellate cell
References
- ^ a b Stanciu A, Cotutiu C, Amalinei C (2002). "New data about ITO cells". Rev Med Chir Soc Med Nat Iasi. 107 (2): 235–239. PMID 12638266.
- ^ Motoyama H (Feb 2014). "Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver.". Lab Invest. 94 (2): 192–207. doi:10.1038/labinvest.2013.135. PMID 24296877.
- ^ Kobold D, Grundmann A, Piscaglia F, Eisenbach C, Neubauer K, Steffgen J, Ramadori G, Knittel T. (2002). "Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts". J Hepatol. 36 (5): 607–13. doi:10.1016/S0168-8278(02)00050-8. PMID 11983443.
- ^ Geerts A (2001). "History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells". Semin Liver Dis. 21 (3): 311–35. doi:10.1055/s-2001-17550. PMID 11586463.
- ^ Winau F, Hegasy G, Weiskirchen R, et al. (January 2007). "Ito cells are liver-resident antigen-presenting cells for activating T cell responses". 26 (1): 117–29. doi:10.1016/j.immuni.2006.11.011. PMID 17239632.
- ^ "mesenchymal stem cell treatments for ischemic kidney disease". Retrieved 2012-08-07.
- ^ Krizhanovsky V, Yon M, Dickins RA, et al. (August 2008). "Senescence of activated stellate cells limits liver fibrosis". 134 (4): 657–67. doi:10.1016/j.cell.2008.06.049. PMC 3073300. PMID 18724938.
- ^ Suematsu M, Aiso S (2001). "Professor Toshio Ito: a clairvoyant in pericyte biology" (PDF). The Keio Journal of Medicine. 50 (2): 66–71. PMID 11450594.
External links
- MedEd at Loyola orfpath/murali2.htm
- Liver Research at AU-KBC Stellate cell biology
|
Cells in humans derived from endoderm
|
|
| Foregut |
| Respiratory |
- Pneumocyte
- Club cell
- Goblet cell
|
|
| Digestive |
| Stomach |
- Enteroendocrine cell
- G cell
- Delta cell
- Enterochromaffin-like cell
- Gastric chief cell
- Parietal cell
- Foveolar cell
|
|
| Intestine |
- Enteroendocrine cell
- Gastric inhibitory polypeptide
- S cell
- Delta cell
- Cholecystokinin
- Goblet cell
- Paneth cell
- Tuft cell
- Enterocyte
|
|
| Liver |
- Hepatocyte
- Hepatic stellate cell
- (Kupffer cell from mesoderm)
|
|
| Gallbladder |
|
|
| Exocrine pancreas |
- Centroacinar cell
- Pancreatic stellate cell
|
|
|
| Islets of Langerhans |
- alpha cell
- beta cell
- delta cell
- F cell(PP cell
- epsilon cell
|
|
|
| Pharyngeal pouch |
- Thyroid gland
- Parathyroid gland
- Parathyroid chief cell
- Oxyphil cell
|
|
| Hindgut/cloaca |
|
|
Anatomy of the liver, pancreas and biliary tree
|
|
| Liver |
- Bare area of the liver
- Ligamentum venosum
- Porta hepatis
- Round ligament of liver
- Lobes
- Left
- Right (Caudate
- Quadrate)
- Fibrous capsule of Glisson
- Perisinusoidal space
- Liver sinusoid
- Periportal space
- Portal triad
- Lobules of liver
- Microanatomy
- Hepatocyte
- Hepatic stellate cell
- Kupffer cell
|
|
| Biliary tract |
| Bile ducts |
- Intrahepatic bile ducts
- Bile canaliculus
- Canals of Hering
- Interlobular bile ducts
- Left hepatic duct
- Right hepatic duct
- Common hepatic duct
|
|
| Gallbladder |
- Cystic duct
- Common bile duct
- Ampulla of Vater
- Cells
|
|
|
| Pancreas |
- Gross
- Tail
- Body
- Neck
- Head (Uncinate process)
- Ducts
- Microanatomy
- Pancreatic islets
- Centroacinar cell
- Stellate cell
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Recent insights on the role of cholesterol in non-alcoholic fatty liver disease.
- Arguello G1, Balboa E2, Arrese M3, Zanlungo S4.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1852(9):1765-78. doi: 10.1016/j.bbadis.2015.05.015. Epub 2015 May 29.
- Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of hepatic histopathological changes ranging from non-inflammatory intracellular fat deposition to non-alcoholic steatohepatitis (NASH), which may progress into hepatic fibrosis, cirrhosis, or hepatocellular carcinoma. NAFLD hallmark i
- PMID 26027904
- Hepatic myofibroblasts and fibrogenic progression of chronic liver diseases.
- Novo E1, Cannito S1, Morello E1, Paternostro C1, Bocca C1, Miglietta A1, Parola M2.
- Histology and histopathology.Histol Histopathol.2015 Sep;30(9):1011-32. doi: 10.14670/HH-11-623. Epub 2015 Apr 21.
- Liver fibrogenesis is a dynamic and highly integrated molecular, tissue and cellular process that during the course of a chronic liver disease (CLD) leads progressively to an excess deposition of extracellular matrix (ECM) components in an attempt to limit the consequences of chronic parenchymal inj
- PMID 25896393
- Identification of novel targets for the diagnosis and treatment of liver fibrosis.
- Fagone P1, Mangano K1, Mammana S1, Pesce A2, Pesce A2, Caltabiano R2, Giorlandino A2, Portale TR2, Cavalli E1, Lombardo GA1, Coco M1, Puleo S2, Nicoletti F1.
- International journal of molecular medicine.Int J Mol Med.2015 Sep;36(3):747-752. doi: 10.3892/ijmm.2015.2264. Epub 2015 Jun 29.
- Liver fibrosis is characterized by the excessive deposition of extracellular matrix (ECM) in the hepatic parenchyma and represents an intrinsic response to chronic injury, maintaining organ integrity when extensive necrosis or apoptosis occurs. Hepatic stellate cells (HSCs) are the major cell type
- PMID 26135677
Japanese Journal
- Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis
- 平成27年度奈良県医師会学術奨励賞 非アルコール性脂肪肝炎(NASH)モデルのラットにおいて、エンドトキシンの減少が肝星細胞の活性化抑制と腸管透過性改善を介して肝線維化進展を抑制する
- 奈良県医師会医学会年報 = The Annals of the Nara Medical Association 29(1), 75-80, 2016
- NAID 40020982272
- Protective Effects of Ethyl Acetate Soluble Fraction of Limonium tetragonum on Diethylnitrosamine-Induced Liver Fibrosis in Rats
Related Links
- Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis Kita Yuki , Takamura Toshinari , Misu Hirofumi ...
- コスモ･バイオ（プライマリーセル事業部）は、SciencCell research laboratories社のヒト細胞関連製品を販売しています。 ヒト由来の初代培養細胞である肝星状細胞（Human Hepatic Stellate Cells）の凍結細胞をご用意しています。
★リンクテーブル★
[★]
- 英
- stellate cell
- 同
- 脂肪摂取細胞 fat-storing cells、伊東細胞 Ito cell、肝星細胞 hepatic stellate cell、介在細胞 interstitial cell、類洞周囲脂質細胞 perisinusoidal lipocyte、リポサイト lipocyte、ビタミンA貯蔵細胞 vitamin A storing cell
- 関
- ディッセ腔、肝実質細胞、クッパー細胞、類洞周囲腔
[show details]
概念
- 肝臓のディッセ腔に局在(肝臓実質細胞と類洞内皮細胞の間)
機能
- ビタミンAの貯蔵：ビタミンAの恒常性に関与
- 線維化への関与：肝硬変などで線維芽細胞・筋線維芽細胞のような細胞に変化してコラーゲンなどの細胞外基質を分泌
[★]
- 関
- haematopoietic stem cell、hematopoietic stem cell、hepatic stellate cell
[★]
- 英
- hepatic stellate cell、HSC
- 関
- 造血幹細胞
[★]
- 関
- hepato、hepatogenic、liver
[★]
- 関
- asteroid、astral
[★]
[★]
細胞