WordNet

pertaining to or affecting the liver; "hepatic ducts"; "hepatic cirrhosis"

PrepTutorEJDIC

肝臓の;肝臓にきく,肝臓のような色の

English Journal

Isolation of canine mesenchymal stem cells from amniotic fluid and differentiation into hepatocyte-like cells.

Choi SA, Choi HS, Kim KJ, Lee DS, Lee JH, Park JY, Kim EY, Li X, Oh HY, Lee DS, Kim MK.SourceDepartment of Animal Science and Biotechnology, College of Agriculture and Life Science, Chungnam National University, Daejeon, 305-764, Republic of Korea.
In vitro cellular & developmental biology. Animal.In Vitro Cell Dev Biol Anim.2013 Jan;49(1):42-51. doi: 10.1007/s11626-012-9569-x. Epub 2012 Dec 15.
Recent findings have demonstrated that amniotic fluid cells are an interesting and potential source of mesenchymal stem cells (MSCs). In this study, we isolated MSCs from canine amniotic fluid and then characterized their multilineage differentiation ability. Canine amniotic fluid stem (cAFS) cells
PMID 23242927

Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells.

Murphy SV, Atala A.SourceWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Seminars in reproductive medicine.Semin Reprod Med.2013 Jan;31(1):62-8. doi: 10.1055/s-0032-1331799. Epub 2013 Jan 17.
Gestational tissue such as the placenta, placental membranes, and amniotic fluid are usually discarded following birth. Recently, researchers have identified gestational tissue as an untapped source of stem cells that are highly multipotent and possess potent immunosuppressive properties. Placental
PMID 23329638

Adult human liver mesenchymal stem/progenitor cells participate to mouse liver regeneration after hepatectomy.

Khuu DN, Nyabi O, Maerckx C, Sokal E, Najimi M.AbstractThe advances in stem cell science have promoted research on their use in liver regenerative medicine. Beyond the demonstration of their ability to display metabolic functions in vitro, candidate cells should demonstrate achievable in situ differentiation, and ability to participate to liver repopulation. In this work, we studied the in vivo behaviour of adult liver mesenchymal stem/progenitor cells (ADHLSCs) after transplantation into immuno-deficient mice. Kinetic of engraftment and in situ hepatogenic differentiation were analyzed. Response of transplanted ADHLSCs to regenerative stimulus has also been evaluated. Non-differentiated ADHLSCs were intrasplenically transplanted into SCID mice. Efficiency of transplantation was evaluated at the level of engraftment and in situ differentiation using immunohistochemistry, in situ hybridization and RT-PCR. After bromodeoxyuridine (BrdU) implantation, proliferation of transplanted ADHLSCs in response to 20% hepatectomy was assessed using immunohistochemistry. We demonstrated that ADHLSC engraftment in the SCID mouse liver was low, but remained stable up to 60 days post-transplantation, when albumin (ALB) immuno-positive ADHLSCs were still detected and organized as clusters. Co-expression of ornithine transcarbamylase (OTC) demonstrated ADHLSC in situ differentiation mostly near the hepatic portal vein. After 20% hepatectomy on one month transplanted mice, the percentage of BrdU and human ALB immuno-positive ADHLSCs increased from 3 to 28 days post-BrdU implantation to reach 31.3 ± 5.4% of the total analyzed human cells. In the current study, we demonstrate that transplanted ADHLSCs are able to differentiate in the non pre-conditioned SCID mouse liver mainly in the peri-portal area. In response to partial hepatectomy, integrated ADHLSCs proliferate and participate to recipient mouse liver regeneration.
Cell transplantation.Cell Transplant.2012 Dec 4. [Epub ahead of print]
The advances in stem cell science have promoted research on their use in liver regenerative medicine. Beyond the demonstration of their ability to display metabolic functions in vitro, candidate cells should demonstrate achievable in situ differentiation, and ability to participate to liver repopula
PMID 23211283