glutamic-pyruvic transaminase

アラニンアミノトランスフェラーゼ

WordNet

1. a class of transferases that catalyze transamination (that transfer an amino group from an amino acid to another compound) (同)aminotransferase, aminopherase

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• 1. 肝細胞障害を検出するための肝臓生化学検査liver biochemical tests that detect injury to hepatocytes [show details]
  … (formerly called transaminases) are sensitive indicators of liver cell injury . The most commonly measured are alanine aminotransferase (ALT, serum glutamic-pyruvic transaminase [SGPT]) and… suggested that glutamate dehydrogenase may be a sensitive and relatively specific marker for alcohol-associated hepatitis, this observation has not been confirmed by others . Glutamate dehydrogenase… group of ketoglutarate, which results in the formation of pyruvate and oxaloacetate. The serum ALT and AST concentrations are normally less than 30 to 40 international unit/L(0.5001 to 0.6668 microkatal/liter) …
• 2. ホスホリラーゼbキナーゼ欠損症phosphorylase b kinase deficiency [show details]
  …percent; Hypercholesterolemia – 76 percent; Hypertriglyceridemia – 70 percent; Elevated glutamate pyruvate transaminase – 56 percent; Fasting hyperketosis – 44 percent; The course generally is benign. Symptoms…
• 3. 小児におけるエタノール中毒：疫学、毒性の推定、および毒性作用ethanol intoxication in children epidemiology estimation of toxicity and toxic effects [show details]
  … by activation of the N-methyl-D-aspartate (NMDA) type glutamate receptor .… The alteration of the NAD+ to NADH ratio during ethanol metabolism also favors the conversion of pyruvate to lactate . These metabolic changes result in mild to moderate metabolic acidosis . In addition…
• 4. 尿素サイクル障害：臨床的特徴および診断urea cycle disorders clinical features and diagnosis [show details]
  … MIM #207900) N-acetyl glutamate synthetase (NAGS) deficiency (MIM#237310) Arginase deficiency (MIM #207800) UCDs,… causes of hyperammonemia include organic acidemias, fatty acid oxidation defects, and disorders of pyruvate metabolism . Hyperammonemia in organic acidemias results from inhibition of one of the urea cycle …
• 5. メープルシロップ尿症の概要overview of maple syrup urine disease [show details]
  …nervous system , exerting direct and indirect neurotoxic effects through tissue swelling, impaired glutamate homeostasis, and relative deficiency of large neutral amino acids, resulting in reduced neurotransmitter … and valine), including alloisoleucine and urine levels of branched-chain ketoacids, lactate, and pyruvate. Classic MSUD is the most common form of the disorder. It results from pathogenic variants in the …

English Journal

• Dynamics of HCV RNA levels during acute hepatitis C virus infection.

• Hajarizadeh B1, Grebely J, Applegate T, Matthews GV, Amin J, Petoumenos K, Hellard M, Rawlinson W, Lloyd A, Kaldor J, Dore GJ; ATAHC study group.
• Journal of medical virology.J Med Virol.2014 Oct;86(10):1722-9. doi: 10.1002/jmv.24010. Epub 2014 Jul 8.
• Understanding viral dynamics during acute hepatitis C virus (HCV) infection can provide important insights into immunopathogenesis and guide early treatment. The aim of this study was to investigate the dynamics of HCV RNA and alanine transaminase (ALT) levels during recent HCV infection in the Aust
• PMID 25042465

• Anti-arthritic activity of N'-[(2,4-dihydroxyphenyl)methylidene]-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-1(4H)-yl)acetohydrazide.

• Shabbir A1, Shahzad M2, Ali A3, Zia-Ur-Rehman M4.
• European journal of pharmacology.Eur J Pharmacol.2014 Sep 5;738:263-72. doi: 10.1016/j.ejphar.2014.05.045. Epub 2014 Jun 2.
• Benzothiazine and pyrazole derivatives possess anti-inflammatory properties. Previously, synergism of both heterocyclic moieties into a single nucleus has shown to produce biologically active N'-arylmethylidene-2-(3,4-dimethyl-5,5-dioxidopyrazolo(4,3-c)(1,2)benzothiazin-2(4H)yl)acetohydrazides) comp
• PMID 24943733

• Effect of bone marrow-derived mesenchymal stromal cells on hepatoma.

• Abd-Allah SH1, Shalaby SM1, El-Shal AS2, Elkader EA1, Hussein S1, Emam E3, Mazen NF4, El Kateb M5, Atfy M6.
• Cytotherapy.Cytotherapy.2014 Sep;16(9):1197-206. doi: 10.1016/j.jcyt.2014.05.006. Epub 2014 Jun 27.
• BACKGROUND AIMS: The aim of the study was to evaluate the effect of mesenchymal stromal cells (MSCs) on tumor cell growth in vitro and in vivo and to elucidate the apoptotic and anti-proliferative mechanisms of MSCs on a hepatocellular carcinoma (HCC) murine model.METHODS: The growth-inhibitory effe
• PMID 24985939

Japanese Journal

• Anti-Obesity Properties of a Sasa quelpaertensis Extract in High-Fat Diet-Induced Obese Mice

• KANG Seong-Il,SHIN Hye-Sun,KIM Hyo-Min [他],HONG Youn-Suk,YOON Seon-A,KANG Seung-Woo,KIM Jeong-Hwan,KO Hee-Chul,KIM Se-Jae
• Bioscience, biotechnology, and biochemistry 76(4), 755-761, 2012-04-23
• … SQE administration also reduced the serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactate dehydrogenase, and the accumulation of lipid droplets in the liver, suggesting a protective effect against HFD-induced hepatic steatosis. …
• NAID 10030751808

• Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by .BETA.-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice

• Kang Seong-Il,Shin Hye-Sun,Kim Hyo-Min [他],Hong Youn-Suk,Yoon Seon-A,Kang Seung-Woo,Kim Jeong-Hwan,Kim Moo-Han,Ko Hee-Chul,Kim Se-Jae
• Biological and Pharmaceutical Bulletin 35(2), 223-230, 2012
• … Also, CSE supplementation reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase. …
• NAID 130001872297

• Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice

• Toyota Teruaki,Kataoka Takahiro,Nishiyama Yuichi,Taguchi Takehito,Yamaoka Kiyonori
• Mediators of Inflammation 2012, 2012
• … Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. …
• NAID 120005353353

Related Links

• Glutamic-pyruvic transaminase | definition of glutamic-pyruvic ...

The concentrations of total cholesterol (Total-C) and the activities of glutamicoxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) in serum were measured according to the colorimetric method using a cholesterol ...

• GPT glutamic--pyruvic transaminase [ (human)]

... glutamic--pyruvic transaminase 1, glutamic-alanine transaminase 1, glutamic-pyruvate transaminase (alanine aminotransferase) GeneRIFs: Gene References Into Functions The serum hepcidin, ferritin, alanine transaminase ...

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★リンクテーブル★

リンク元	「アラニンアミノトランスフェラーゼ」
関連記事	「glutamic」「transaminase」

「アラニンアミノトランスフェラーゼ」

　　[★]

英

alanine aminotransferase, L-alanine aminotransferase, ALT

同

グルタミン酸ピルビン酸トランスアミナーゼ glutamic-pyruvic transaminase, GPT

グルタミン酸アラニントランスアミナーゼ glutamic-alanine transaminase、L-アラニン:2-オキソグルタル酸アミノトランスフェラーゼ L-alanine:2-oxoglutarateaminotransferase

関

アスパラギン酸アミノ基転移酵素 AST、マクロALT。アミノ転移

• 臨床検査医学 090113

概念

• 肝細胞からの逸脱酵素。肝以外での含有量は少ない。
• 旧来のGPTおなじ
• 肝細胞障害の指標　→　炎症が沈静化していれば(慢性肝炎や肝硬変の末期)、正常範囲を示しうる。

酵素

http://www.uniprot.org/uniprot/P24298

• EC 2.6.1.2。
• 分子量：54,637Da

機能

• 可逆的アミノ基転移反応を触媒する
• L-アラニン（L-alanine）＋2-オキソグルタル酸（2-oxoglutarate）＝ピルビン酸（pyruvate）＋L-グルタミン酸（L-glutamate
• 補酵素：ピリドキサールリン酸（VB6）補酵素
• 組織の炎症や挫滅により血中に逸脱
• 消化管から由来する大量のアラニンを肝臓でピルビン酸へと変換し，糖新生の基質として供給
• 全身に存在するが、特に肝臓に多い。

臨床検査

• 基準値：4-43U/L。7-41 U/L(HIM A-3)

• 1,000U/L以上

急性ウイルス肝炎

判別

• 高度上昇　：急性肝炎、劇症肝炎、ショック
• 中程度上昇：急性肝炎ｍ慢性活動性肝炎、閉塞性黄疸
• 軽度上昇　：脂肪肝、肝硬変、アルコール性肝障害、胆石発作、肝癌、心筋梗塞(うっ血肝により肝細胞障害を来し、軽度上昇)

• ALTは慢性期な疾患でASTより優位となる。(アルコール性の肝疾患や肝硬変、肝癌は異なる)
• 急性ウイルス性肝炎(極期)、慢性肝炎、過栄養性脂肪肝

	AST	ALT
含有量	3	1
局在	心筋、肝臓、 骨格筋、腎臓 赤血球	肝臓、腎臓、 心臓、骨格筋
逸脱しやすさ	逸脱しにくい	逸脱しやすい
血中半減期	2日	6日
肝小葉内の分泌	中心静脈	辺縁

• http://hobab.fc2web.com/sub4-AST.htm

「glutamic」

　　[★]

• グルタミン酸の

関

E、Glu、glutamate、glutamic acid、L-glutamic acid

「transaminase」

　　[★] トランスアミナーゼ