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1. 好酸球の生物学および好酸球増多症の原因eosinophil biology and causes of eosinophilia [show details]
… (eg, allergic bronchopulmonary aspergillosis [ABPA], EGPA, nasal polyposis). Other pulmonary diseases – Abnormally high numbers of eosinophils may be seen in the pulmonary parenchyma in many conditions …
2. 原因不明の好酸球増加症患者に対するアプローチapproach to the patient with unexplained eosinophilia [show details]
… expertise in eosinophil disorders should be considered if testing does not suggest an infectious cause for gastrointestinal complaints. Eosinophilia with cough, dyspnea, wheezing, chronic nasal complaints… thorough physical examination should seek evidence of organ involvement and/or possible causes of eosinophilia. The examination should include a complete skin examination and evaluation for…
3. 慢性副鼻腔炎：臨床症状、病態生理、および診断chronic rhinosinusitis clinical manifestations pathophysiology and diagnosis [show details]
… persistently bloody nasal discharge, nonhealing nasal lesions, nasal septal perforation with bleeding and crusting, and collapse of the nasal bridge.… On physical examination, large polyps are often visible with anterior rhinoscopy, while smaller polyps require nasal endoscopy or imaging. Nasal polyps lack sensation. Swollen nasal turbinates are… Mixed infiltrates of mononuclear cells and eosinophils are usually present, with a predominancy of eosinophils.…
4. 多発血管炎性肉芽腫症および顕微鏡的多発血管炎：気道病変granulomatosis with polyangiitis and microscopic polyangiitis respiratory tract involvement [show details]
… and ears include the following : Nasal crusting; Sinus pain; Chronic rhinosinusitis; Nasal obstruction; Smell disturbances; Purulent/bloody nasal discharge; Excessive tearing (ie,… Chronic rhinosinusitis – Histopathologic examination of nasal and sinus tissue involved by GPA typically reveals… peripheral blood eosinophilia (usually 5000 to 9000 eosinophils/microL) and nasal polyposis favor EGPA,…
5. アレルギー性鼻炎：臨床症状、疫学、および診断allergic rhinitis clinical manifestations epidemiology and diagnosis [show details]
… purulent/bloody nasal discharge, oral and/or nasal ulcers,… the history and physical examination; Poorly controlled symptoms, such as persistent nasal symptoms and/or an inadequate clinical response to nasal glucocorticoids; Coexisting… patients with significant nasal mucosal swelling and eustachian tube dysfunction ; Routine laboratories are usually normal. Neither peripheral blood eosinophil counts nor total serum…

English Journal

Nasal Discharge Eosinophils in Childhood Asthma Patients as a Predictive Factor for Persistent Asthma.

Murayama N, Murayama K.
Mediators of inflammation. 2018 ;2018()2563978.
Eosinophilic inflammation is thought to play a role in childhood asthma. Thus, examination of nasal eosinophils, instead of sputum, may be useful for the diagnosis of not only eosinophil-positive rhinitis but also persistent asthma. Nasal eosinophil examination is a routine for the diagnosis of nasa
PMID 30662366

Data on nasal eosinophil positive rates in childhood asthma on each age.

Murayama N, Murayama K.
Data in brief. 2018 Oct;20()1573-1579.
Nasal eosinophil examination is routine for the diagnosis of nasal eosinophil-positive rhinitis in patients with rhinorrhea symptoms. This retrospective data investigated whether testing for nasal discharge eosinophils is useful for diagnosing childhood allergic asthma, and changes of positive rates
PMID 30258962

Evaluation of the effect of intranasal infiltrated botulinum toxin-A on a model of allergic rhinitis in rabbits: An Experimental Study.

Güneş MS, Külahlı I, Kökoğlu K, Vural A, Avcı D, Güleç S, Sönmez MF, Çilenk KT, Erçal BD.
International journal of pediatric otorhinolaryngology. 2016 Apr;83()51-6.
Allergic Rhinitis (AR) effects 20-40% of the global population and its prevalance increases. Medical treatment and immunotherapy could be used in AR management. But they are not definitive solution. Medical treatment must be used a long time and has side effects. Immunotherapy cannot be applied to e
PMID 26968053

Japanese Journal

アレルギー性鼻炎における鼻汁中非特異的IgE検査の診断学的有用性の検討

福島慶,竹内裕美,森實理恵 [他],北野博也,硲田猛真,榎本雅夫
日本耳鼻咽喉科學會會報 114(9), 774-779, 2011-09-20
アレルギー性鼻炎の診断は, くしゃみ, 水性鼻汁, 鼻閉の3主徴をもち, 鼻汁好酸球検査, 皮膚テストまたは血清特異的IgE抗体, 鼻誘発テストのうち2項目が陽性の時に確診される. ところで, アレルギー性鼻炎患者の鼻汁にはIgE抗体が含まれていることは知られている. そこで, 鼻汁中非特異的IgE (以下, 鼻汁IgE) 検査のアレルギー性鼻炎における診断的意義について検討した. スギ花粉症患者 …
NAID 10029699693

ハンセン病既往患者の鼻副鼻腔病変の臨床的観察

中林成一郎,鈴木秀明,古川正幸,佐々木伸尚
日本鼻科学会会誌 38(1), 91-98, 1999
… Leprosy patients with long-term quiescent conditions show symptoms such as purulent rhinorrhea, nasal crusting, and atrophy of the nasal conchae. … These symptoms resemble those of atrophic rhinitis. …
NAID 130003873702

小児アレルギー性副鼻腔炎の治療

鈴木正志,渡辺哲生,須小毅,茂木五郎
日本鼻科学会会誌 37(4), 310-315, 1998
… The effect of ketotifen alone and in combination with beclomethasone dipropionate (BDP) and/or erythromycin derivatives was investigated in allergic sinusitis in children younger than 13 years of age. … Group A received 0.06mg/kg of ketotifen alone daily; … group B received ketotifen and 300μg of topical BDP. …
NAID 130003720597