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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/10 14:24:20」(JST)
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| Solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
| Identifiers |
| Symbols |
SLC29A2 ; DER12; ENT2; HNP36 |
| External IDs |
OMIM: 602110 MGI: 1345278 HomoloGene: 37493 GeneCards: SLC29A2 Gene |
| Gene ontology |
| Molecular function |
• nucleoside transmembrane transporter activity
|
| Cellular component |
• nucleolus
• plasma membrane
• integral component of plasma membrane
• basolateral plasma membrane
• nuclear membrane
|
| Biological process |
• nucleobase-containing compound metabolic process
• cell proliferation
• nucleoside transport
• transmembrane transport
• nucleoside transmembrane transport
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
3177 |
13340 |
| Ensembl |
ENSG00000174669 |
ENSMUSG00000024891 |
| UniProt |
Q14542 |
Q61672 |
| RefSeq (mRNA) |
NM_001300868 |
NM_007854 |
| RefSeq (protein) |
NP_001287797 |
NP_031880 |
| Location (UCSC) |
Chr 11:
66.36 – 66.37 Mb |
Chr 19:
5.02 – 5.03 Mb |
| PubMed search |
[1] |
[2] |
|
|
Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.[1][2][3]
See also
- Solute carrier family
- Equilibrative nucleoside transporters
- Nucleoside transporters
References
- ^ Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, Phillips JA 3rd, Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS (Sep 1997). "The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome". Genomics 42 (2): 325–30. doi:10.1006/geno.1997.4751. PMID 9192854.
- ^ Crawford CR, Patel DH, Naeve C, Belt JA (Mar 1998). "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line". J Biol Chem 273 (9): 5288–93. doi:10.1074/jbc.273.9.5288. PMID 9478986.
- ^ "Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2".
Further reading
- Baldwin SA, Beal PR, Yao SY; et al. (2004). "The equilibrative nucleoside transporter family, SLC29.". Pflugers Arch. 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422.
- Mangravite LM, Badagnani I, Giacomini KM (2004). "Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney.". Eur. J. Pharmacol. 479 (1-3): 269–81. doi:10.1016/j.ejphar.2003.08.076. PMID 14612157.
- Williams JB, Lanahan AA (1995). "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein.". Biochem. Biophys. Res. Commun. 213 (1): 325–33. doi:10.1006/bbrc.1995.2133. PMID 7639753.
- Griffiths M, Yao SY, Abidi F; et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.". Biochem. J. 328 (3): 739–43. PMC 1218980. PMID 9396714.
- Yao SY, Ng AM, Vickers MF; et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.". J. Biol. Chem. 277 (28): 24938–48. doi:10.1074/jbc.M200966200. PMID 12006583.
- Molina-Arcas M, Bellosillo B, Casado FJ; et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia.". Blood 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552.
- Ward JL, Leung GP, Toan SV, Tse CM (2003). "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.". Arch. Biochem. Biophys. 411 (1): 19–26. doi:10.1016/S0003-9861(02)00718-X. PMID 12590919.
- Szkotak AJ, Ng AM, Man SF; et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells.". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Farré X, Guillén-Gómez E, Sánchez L; et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.". Int. J. Cancer 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Visser F, Zhang J, Raborn RT; et al. (2005). "Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites.". Mol. Pharmacol. 67 (4): 1291–8. doi:10.1124/mol.104.005884. PMID 15644498.
- Visser F, Baldwin SA, Isaac RE; et al. (2005). "Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters.". J. Biol. Chem. 280 (12): 11025–34. doi:10.1074/jbc.M410348200. PMID 15649894.
- Owen RP, Lagpacan LL, Taylor TR; et al. (2006). "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.". Drug Metab. Dispos. 34 (1): 12–5. doi:10.1124/dmd.105.006270. PMID 16214850.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
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Ion pumps
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| Symporter, Cotransporter |
- Na+/K+,l-
- Na/Pi3
- Na+/Cl-
- Na/glucose
- Na+/I-
- Cl-/K+
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| Antiporter (exchanger) |
- Na+/H+
- Na+/Ca2+
- Na+/(Ca2+-K+) - Cl-/HCO3- (Band 3)
- Cl-formate exchanger
- Cl-oxalate exchanger
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see also solute carrier disorders
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Index of cells
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| Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
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| Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
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English Journal
- Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.
- Klein DM, Evans KK, Hardwick RN, Dantzler WH, Wright SH, Cherrington NJ.SourceDepartment of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2013 Jul;346(1):121-9. doi: 10.1124/jpet.113.203265. Epub 2013 May 2.
- The blood-testis barrier (BTB) prevents the entry of many xenobiotic compounds into seminiferous tubules thereby protecting developing germ cells. Understanding drug transport across the BTB may improve drug delivery into the testis. Members of one class of drug, nucleoside reverse transcriptase inh
- PMID 23639800
- Hypoxia alters ocular drug transporter expression and activity in rat and calf models: implications for drug delivery.
- Kadam RS, Ramamoorthy P, LaFlamme DJ, McKinsey TA, Kompella UB.SourcePharmaceutical Sciences and Ophthalmology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA.
- Molecular pharmaceutics.Mol Pharm.2013 Jun 3;10(6):2350-61. doi: 10.1021/mp3007133. Epub 2013 May 22.
- Chronic hypoxia, a key stimulus for neovascularization, has been implicated in the pathology of proliferative diabetic retinopathy, retinopathy of prematurity, and wet age related macular degeneration. The aim of the present study was to determine the effect of chronic hypoxia on drug transporter mR
- PMID 23607566
- Tubuloglomerular feedback and renal function in mice with targeted deletion of the type 1 equilibrative nucleoside transporter.
- Li L, Mizel D, Huang Y, Eisner C, Hoerl M, Thiel M, Schnermann J.SourceKidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
- American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Feb 15;304(4):F382-9. doi: 10.1152/ajprenal.00581.2012. Epub 2012 Dec 26.
- A(1) adenosine receptors (A1AR) are required for the modulation of afferent arteriolar tone by changes in luminal NaCl concentration implying that extracellular adenosine concentrations need to change in synchrony with NaCl. The present experiments were performed in mice with a null mutation in the
- PMID 23269643
Related Links
- Complete information for SLC29A2 gene (Protein Coding), Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... ...
- (Earliest) J:27223 Lanahan A, et al., Growth factor-induced delayed early response genes. Mol Cell Biol. 1992 Sep;12(9):3919-29 (Latest) J:221772 Morote-Garcia JC, et al., Repression of the equilibrative nucleoside transporters ...
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