endothelium-derived relaxing factor

関

also Nitric oxide

同

EDRF

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Nitric oxide

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See also Nitric oxide

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
8. a concept whose truth can be proved; "scientific hypotheses are not facts"
9. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
10. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
11. obtain; "derive pleasure from ones garden" (同)gain
12. develop or evolve from a latent or potential state (同)educe
13. come from; "The present name derives from an older form"
14. come from; be connected by a relationship of blood, for example; "She was descended from an old Italian noble family"; "he comes from humble origins" (同)come, descend
15. hormone secreted by the corpus luteum during the last days of pregnancy; relaxes the pelvic ligaments and prepares the uterus for labor
16. an epithelium of mesoblastic origin; a thin layer of flattened cells that lines the inside of some body cavities

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
3. 《『derive』+『名』+『from』+『名』(do『ing』)》(…から)…‘を'『引き出す』,得る,求める / 《『derive from』+『名』(do『ing』)》《文》(…から)派生する,(…に)由来する

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/14 14:18:38」(JST)

wiki en

[Wiki en表示]

Endothelium-derived relaxing factor (EDRF) is produced and released by the endothelium to promote smooth muscle relaxation. The best-characterized is nitric oxide (NO). Some sources equate EDRF and nitric oxide.

It is released in response to a variety of chemical and physical stimuli. It causes the smooth muscle in the vessel wall to relax.

EDRF was discovered and characterized by Robert F. Furchgott, a winner of the Nobel Prize in Medicine in 1998 with his co-researchers Louis J. Ignarro and Ferid Murad.

Shortly after his death in May of 2009, Furchgott's website at SUNY Downstate Medical Center continued to state that his group was "investigating whether the endothelium-derived relaxing factor (EDRF) is simply nitric oxide or a mixture of substances".

Although there is strong evidence that nitric oxide elicits vasodilation, there is some evidence tying this effect to neuronal rather than endothelial reactions.

References

UpToDate Contents

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• 1. 肺高血圧症のある成人における一酸化窒素吸入 inhaled nitric oxide in adults with pulmonary hypertension
• 2. 呼気中一酸化窒素の分析および適用 exhaled nitric oxide analysis and applications
• 3. 心不全における一酸化窒素、その他のホルモン、サイトカイン、およびケモカイン nitric oxide other hormones cytokines and chemokines in heart failure
• 4. 一酸化窒素と腎臓 nitric oxide and the kidney
• 5. 下肢末梢動脈疾患の症状を治療するための試験的治療 investigational therapies for treating symptoms of lower extremity peripheral artery disease

English Journal

• Activation of RAW 264.7 cells by a polysaccharide isolated from Antarctic bacterium Pseudoaltermonas sp. S-5.

• Li J1, Qian W2, Xu Y2, Chen G3, Wang G2, Nie S4, Shen B4, Zhao Z2, Liu C2, Chen K5.
• Carbohydrate polymers.Carbohydr Polym.2015 Oct 5;130:97-103. doi: 10.1016/j.carbpol.2015.04.070. Epub 2015 May 12.
• The aim of this study was to examine the effect of extracellular polysaccharide (PEP) from Antarctic bacterium Pseudoaltermonas sp. S-5 on RAW 264.7 cells together with the underlying signaling pathways. Our results illustrated that PEP induced dendritic-like morphological change in RAW 264.7 cells,
• PMID 26076605

• Lipopolysaccharide and Concanavalin A Differentially Induce the Expression of Immune Response Genes in Caprine Monocyte Derived Macrophages.

• Walia V1, Kumar R, Mitra A.
• Animal biotechnology.Anim Biotechnol.2015 Oct 2;26(4):298-303. doi: 10.1080/10495398.2015.1013112.
• Monocyte derived macrophages (MDMs), as an in vitro model in pathogen challenge studies, are generally induced with lipopolysaccharide (LPS) and concanavalin A (ConA) to assay cellular immunity. General immune responses to LPS and ConA have been studied in a wide range of species, but similar studie
• PMID 26158463

• Nitric oxide influences potassium currents in inner hair cells isolated from guinea-pig cochlea.

• Kimitsuki T1.
• Auris, nasus, larynx.Auris Nasus Larynx.2015 Oct;42(5):360-4. doi: 10.1016/j.anl.2015.02.011. Epub 2015 Mar 10.
• OBJECTIVE: Nitric oxide (NO) is a diffusible second messenger, which regulates neurotransmission, serving as the principal endothelium-derived relaxing factor. NO also acts as an ion channel modulator. Nitric oxide synthase (NOS) has been identified in the inner ear, although its physiological role
• PMID 25769241

Japanese Journal

• Linoleic Acid Attenuates Endothelium-Derived Relaxing Factor Production by Suppressing cAMP-Hydrolyzing Phosphodiesterase Activity

• Wei Jiazhang,Takeuchi Kazuhiko,Watanabe Hiroshi
• Circulation Journal, 2013
• … These molecules are restrained by endothelium-derived relaxing factors (EDRFs), such as nitric oxide (NO) and prostaglandin I2 (PGI2). …
• NAID 130003361824

• 2) 一酸化窒素-Arginase代謝系による動脈硬化の発症・防御機構とエストロゲンの関与(シンポジウム1:女性ヘルスケア「中高年に対する女性医学の展開」,第64回日本産科婦人科学会・学術講演会)

• 尾林 聰
• 日本産科婦人科學會雜誌 64(10), 2180-2190, 2012-10-01
• … The mechanism to occur intimal hyperplasia is complex and poorly understood, but it is well established that dysfunction in endothelium is one of the important mechanisms to cause atherosclerosis. … Nowadays, endothelium-derived nitric oxide (NO) is recognized as the key factor to regulate atherosclerosis. …
• NAID 110009518074

• Mechanisms for Enhanced Endothelium-Derived Hyperpolarizing Factor-Mediated Responses in Microvessels in Mice

• OHASHI Junko,SAWADA Ayuko,NAKAJIMA Sota,NODA Kazuki,TAKAKI Aya,SHIMOKAWA Hiroaki
• Circulation journal : official journal of the Japanese Circulation Society 76(7), 1768-1779, 2012-06-25
• … Background: Endothelium-derived relaxing factors play an important role in cardiovascular homeostasis. … Among them, endothelium-derived hyperpolarizing factor (EDHF) is important especially in microcirculation. …
• NAID 10030503846

Related Links

• endothelium-derived relaxing factor - definition of endothelium ...

factor [fak´ter] an agent or element that contributes to the production of a result. accelerator factor factor V, one of the coagulation factors. factor I see coagulation factors. factor II see coagulation factors. factor III see coagulation ...

• Endothelium-derived_relaxing_factor

Endothelium-derived relaxing factor This article is about the biological functions of nitric oxide. For the chemical compound in a general sense, see Nitric ... my.chemeurope.com With an accout for my.chemeurope.com you can ...

Related Pictures

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★リンクテーブル★

リンク元	「endothelium-dependent vasodilator」「内皮細胞由来弛緩因子」「endothelium-dependent relaxing factor」「EDRF」
関連記事	「derive」「fact」「factor」「endothelium」

「endothelium-dependent vasodilator」

　　[★]

• 内皮依存性血管拡張薬

関

endothelium-dependent relaxing factor、endothelium-derived relaxing factor

「内皮細胞由来弛緩因子」

　　[★]

英

endothelium-derived relaxing factor, EDRF

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血管内皮細胞由来弛緩因子

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内皮細胞

「endothelium-dependent relaxing factor」

　　[★]

• 内皮依存性弛緩因子

関

endothelium-dependent vasodilator、endothelium-derived relaxing factor

「EDRF」

　　[★] 内皮細胞由来弛緩因子 endothelium-derived relaxing factor

「derive」

　　[★]

• vt.

• 由来する

同

stem

• 由来する、派生する、引き出す

関

borne、come from、descend、draw、educe、elicit、stem

　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

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actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「endothelium」

　　[★] 内皮

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vessel wall