WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
material of a particular kind or constitution; "the immune response recognizes invading substances"
a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
the real physical matter of which a person or thing consists; "DNA is the substance of our genes"
of or resembling an endogen
derived or originating internally (同)endogenic
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
an alkaloid narcotic drug extracted from opium; a powerful, habit-forming narcotic used to relieve pain (同)morphia

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
〈U〉『物質』,物 / 〈U〉《the~》(…の)『趣旨』,本音《+of+名》 / 〈U〉(スープなどの)濃さ,こく,中身[の詰まっていること] / 〈U〉『実質』,実 / 〈U〉《古》財産,資産
(生物が)内部から成長する,内性の,内因性の
(…の)『好み』,趣味《+『for』(『to』)+『名』》
モルヒネ(鎮痛・麻酔剤)

UpToDate Contents

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1. オピオイド系薬剤を用いた癌疼痛のマネージメント：至適鎮痛作用 cancer pain management with opioids optimizing analgesia
2. 小児および思春期におけるオピオイド中毒 opioid intoxication in children and adolescents
3. 統合失調症と物質使用障害の併発：疫学、病因、臨床症状、および診断 co occurring schizophrenia and substance use disorder epidemiology pathogenesis clinical manifestations and diagnosis
4. 危篤状態の成人患者における疼痛管理 pain control in the critically ill adult patient
5. 統合失調症と物質使用障害の併発に対する治療 treatment of co occurring schizophrenia and substance use disorder

English Journal

Cholecystokinin octapeptide induces endogenous opioid-dependent anxiolytic effects in morphine-withdrawal rats.

Wen D1, Sun D1, Zang G1, Hao L1, Liu X1, Yu F1, Ma C2, Cong B3.
Neuroscience.Neuroscience.2014 Sep 26;277:14-25. doi: 10.1016/j.neuroscience.2014.06.048. Epub 2014 Jun 30.
Cholecystokinin octapeptide (CCK-8), a brain-gut peptide, plays an important role in several opioid addictive behaviors. We previously reported that CCK-8 attenuated the expression and reinstatement of morphine-induced conditioned place preference. The possible effects of CCK-8 on the negative affec
PMID 24993476

15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse.

Charbogne P1, Kieffer BL, Befort K.
Neuropharmacology.Neuropharmacology.2014 Jan;76 Pt B:204-17. doi: 10.1016/j.neuropharm.2013.08.028. Epub 2013 Sep 10.
The endogenous opioid system is expressed throughout the brain reinforcement circuitry, and plays a major role in reward processing, mood control and the development of addiction. This neuromodulator system is composed of three receptors, mu, delta and kappa, interacting with a family of opioid pept
PMID 24035914

Endogenous opiates and behavior: 2012.

Bodnar RJ1.
Peptides.Peptides.2013 Dec;50:55-95. doi: 10.1016/j.peptides.2013.10.001. Epub 2013 Oct 12.
This paper is the thirty-fifth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2012 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors,
PMID 24126281

Japanese Journal

Radioreceptor-assayによるヒト髄液中methionine-enkephalin様物質の測定

古井倫士 [他],景山直樹,芳賀達也,市山新,福島雅典
日本内分泌学会雑誌 56(5), 649-661, 1980
… In recent years it has been stated that endogenous morphine-like substances, opioid peptides, exist in the brain and the pituitary gland. … Two pentapeptides with a morphine-like activity, methionine (met) - and leucine-enkephalin, are distributed in the whole brain and highly concentrated in the basal ganglia. …
NAID 130001938164

針刺激, 仰臥位, 耳介の強圧及びモルヒネに共通に反応する無麻酔・無拘束家兎の中脳中心部ニューロン活動

鎌田康夫,武重千冬
昭和医学会雑誌 38(3), 305-314, 1978
無麻酔, 無拘束家兎の中脳中心灰白質, 中脳網様体中心部から微小電極を用いて単一ニューロン活動を記録し, 仰臥位, 耳の強圧などの動物催眠を誘起する方法や針刺激によって反応するニューロンを検索した.これらの操作による反応は自発性放電の頻度の増大か減少であり, 30匹の家兎の89個のニューロンにつき126回の操作を行い, 増大するニューロンは28, 減少は63, 不変は35であった.放電頻度の変化の …
NAID 130001823217