伸長因子2キナーゼ
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- an addition to the length of something (同)extension
- the act of lengthening something
- the quality of being elongated
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- the basic unit of money in Papua New Guinea
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- 〈U〉伸長,延長 / 〈C〉伸長部,延長部
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/19 00:08:51」(JST)
[Wiki en表示]
| eukaryotic elongation factor-2 kinase |
| Identifiers |
| EC number |
2.7.11.20 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, an elongation factor 2 kinase (EC 2.7.11.20) is an enzyme that catalyzes the chemical reaction
- ATP + [elongation factor 2] ADP + [elongation factor 2] phosphate
Thus, the two substrates of this enzyme are ATP and elongation factor 2, whereas its two products are ADP and elongation factor 2 phosphate.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[elongation factor 2] phosphotransferase. Other names in common use include Ca/CaM-kinase III, calmodulin-dependent protein kinase III, CaM kinase III, eEF2 kinase, eEF2K, EF2K, and STK19.
References
- Mitsui K, Brady M, Palfrey HC, Nairn AC (1993). "Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas". J. Biol. Chem. 268 (18): 13422–33. PMID 8514778.
- Hincke MT, Nairn AC (Pt 3). "Phosphorylation of elongation factor 2 during Ca(2+)-mediated secretion from rat parotid acini". Biochem. J. 282 (Pt 3): 877–82. PMC 1130869. PMID 1372803. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1130869/.
- Knebel A, Morrice N, Cohen P (2001). "A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38δ". EMBO J. 20 (16): 4360–9. doi:10.1093/emboj/20.16.4360. PMC 125581. PMID 11500363. //www.ncbi.nlm.nih.gov/pmc/articles/PMC125581/.
- Sans MD, Xie Q, Williams JA (2004). "Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini". Biochem. Biophys. Res. Commun. 319 (1): 144–51. doi:10.1016/j.bbrc.2004.04.164. PMID 15158453.
- Browne GJ, Finn SG, Proud CG (2004). "Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398". J. Biol. Chem. 279 (13): 12220–31. doi:10.1074/jbc.M309773200. PMID 14709557.
- Ryazanov AG (2002). "Elongation factor-2 kinase and its newly discovered relatives". FEBS. Lett. 514 (1): 26–9. doi:10.1016/S0014-5793(02)02299-8. PMID 11904175.
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Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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| Polo kinase (EC 2.7.11.21) |
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| Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDC2L5
- CRKRS
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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| (RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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| Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
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| MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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| Tau-protein kinase (EC 2.7.11.26) |
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| (acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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| Tropomyosin kinase (EC 2.7.11.28) |
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| Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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| Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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| MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.
- Tavares CD1, Devkota AK2, Dalby KN3,4, Cho EJ5,6.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1360:19-33. doi: 10.1007/978-1-4939-3073-9_2.
- Protein kinases have emerged as an important class of therapeutic targets, as they are known to be involved in pathological pathways linked to numerous human disorders. Major efforts to discover kinase inhibitors in both academia and pharmaceutical companies have centered on the development of robus
- PMID 26501899
- Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons.
- Kenney JW1, Genheden M1, Moon KM2, Wang X1, Foster LJ2, Proud CG1.
- Journal of neurochemistry.J Neurochem.2015 Oct 20. doi: 10.1111/jnc.13407. [Epub ahead of print]
- Modulation of the elongation phase of protein synthesis is important for numerous physiological processes in both neurons and other cell types. Elongation is primarily regulated via eukaryotic elongation factor 2 kinase (eEF2K). However, the consequence of altering eEF2K activity on the synthesis of
- PMID 26485687
- Spontaneous neurotransmission signals through store-driven Ca(2+) transients to maintain synaptic homeostasis.
- Reese AL1, Kavalali ET1.
- eLife.Elife.2015 Jul 24;4. doi: 10.7554/eLife.09262.
- Spontaneous glutamate release-driven NMDA receptor activity exerts a strong influence on synaptic homeostasis. However, the properties of Ca(2+) signals that mediate this effect remain unclear. Here, using hippocampal neurons labeled with the fluorescent Ca(2+) probes Fluo-4 or GCAMP5, we visualized
- PMID 26208337
Japanese Journal
- Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes
- Saito T.,Nishida K.,Furumatsu T.,Yoshida A.,Ozawa M.,Ozaki T.
- Osteoarthritis and Cartilage 21(1), 165-174, 2013-01
- … Objective: To investigate the inhibitory effects and the regulatory mechanisms of histone deacetylase (HDAC) inhibitors on mechanical stress-induced gene expression of runt-related transcription factor (RUNX)-2 and a disintegrin and metalloproteinase with thrombospondin motif (ADAMTS)-5 in human chondrocytes. … TSA) for 12 h, followed by uniaxial cyclic tensile strain (CTS) (0.5 Hz, 10% elongation), which was applied for 30 min using the ST-140-10 system (STREX, Osaka, Japan). …
- NAID 120005311990
- Control of muscle protein synthesis in response to exercise and amino acids
- Nakai Naoya,Kawano Fuminori,Ohira Yoshinobu
- The Journal of Physical Fitness and Sports Medicine 1(2), 297-305, 2012
- … The intracellular signaling pathways through the mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, are the most established mechanism for controlling muscle protein synthesis. … Acute bouts of resistance exercise and amino acid ingestion independently activate mTOR and its downstream targets that modulate protein translation initiation and elongation. …
- NAID 130001930870
- The β1-integrin-dependent function of RECK in physiologic and tumor angiogenesis
- Miki Takao,Shamma Awad,Kitajima Shunsuke,Takegami Yujiro,Noda Makoto,Nakashima Yasuaki,Watanabe Kenichiro,Takahashi Chiaki
- Molecular Cancer Research 8(5), 655-676, 2010-05
- … Here, we show that an angiogenic factor angiopoietin-1 induces RECK expression in human umbilical vein endothelial cells (HUVEC), and RECK depletion in these cells results in defective vascular tube formation and cellular senescence. … We further observed that RECK depletion downregulates β1-integrin activation, which was associated with decreased autophosphorylation of focal adhesion kinase and increased expression of a cyclin-dependent kinase inhibitor p21CIP1. …
- NAID 120002224338
Related Links
- This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis.
- Publications, Research Grants, Research Topics, Genomes and Genes, Species, Scientific Experts about elongation factor 2 kinase ... Kathryn J Huber-Keener Department of Pharmacology and The Penn State Hershey Cancer ...
★リンクテーブル★
[★]
- 英
- elongation factor 2 kinase
[★]
- 関
- allongement、elongate、expand、extend、extension、lengthen、lengthening、outgrowth、prolong、prolongation
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase