early growth response protein 1

初期増殖応答タンパク質1

関

Egr-1

WordNet

1. very young; "at an early age"
2. before the usual time or the time expected; "she graduated early"; "the house was completed ahead of time" (同)ahead of time, too soon
3. in good time; "he awoke betimes that morning" (同)betimes
4. belonging to the distant past; "the early inhabitants of Europe"; "former generations"; "in other times" (同)former, other
5. at or near the beginning of a period of time or course of events or before the usual or expected time; "early morning"; "an early warning"; "early diagnosis"; "an early death"; "took early retirement"; "an early spring"; "early varieties of peas and tomatoes mature before most standard varieties"
6. being or occurring at an early stage of development; "in an early stage"; "early forms of life"; "early man"; "an early computer"
7. expected in the near future; "look for an early end to the negotiations"
8. of an early stage in the development of a language or literature; "the Early Hebrew alphabetical script is that used mainly from the 11th to the 6th centuries B.C."; "Early Modern English is represented in documents printed from 1476 to 1700"
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. a result; "this situation developed in response to events in Africa"
21. a phrase recited or sung by the congregation following a versicle by the priest or minister
22. the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
23. fruiting spike of a cereal plant especially corn (同)spike, capitulum
24. attention to what is said; "he tried to get her ear"
25. good hearing; "he had a keen ear"; "a good ear for pitch"
26. the sense organ for hearing and equilibrium

PrepTutorEJDIC

1. (時間・時期が)『早い』,『初期の』 / 昔の / (普通より,予定より)早い / 近い将来の / (時間・時期的に)『早く』 / (予定・ふだんより)早く
2. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
3. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
4. 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
5. 〈C〉『耳』 / 《単数形で》『聴覚』,聴力,音感 / 《単数形で》じっと聞くこと,傾聴 / 〈C〉耳の形をした物
6. (麦・とうもろこしなどの)穂

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/12/03 23:50:26」(JST)

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EGR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4R2A, 4R2C, 4R2D, 4X9J
Identifiers
Aliases	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225, early growth response 1
External IDs	OMIM: 128990 MGI: 95295 HomoloGene: 56394 GeneCards: EGR1
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.2 Start 138,465,490 bp End 138,469,315 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18 B1|18 18.76 cM Start 34,859,823 bp End 34,864,984 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription regulatory region sequence-specific DNA binding • metal ion binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • histone acetyltransferase binding • nucleic acid binding • transcription regulatory region DNA binding • hemi-methylated DNA-binding • double-stranded methylated DNA binding • zinc ion binding • promoter-specific chromatin binding Cellular component • nucleoplasm • cell nucleus • cytoplasm Biological process • regulation of apoptotic process • cellular response to organic substance • regulation of transcription, DNA-templated • glomerular mesangial cell proliferation • negative regulation of transcription from RNA polymerase II promoter • response to glucose • transcription from RNA polymerase II promoter • BMP signaling pathway • transcription, DNA-templated • positive regulation of transcription, DNA-templated • response to insulin • interleukin-1-mediated signaling pathway • cellular response to mycophenolic acid • T cell differentiation • type I interferon signaling pathway • positive regulation of glomerular metanephric mesangial cell proliferation • cellular response to gamma radiation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • skeletal muscle cell differentiation • cellular response to heparin • regulation of protein sumoylation • negative regulation of canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • cellular response to interleukin-8 • response to hypoxia • response to ischemia • estrous cycle • positive regulation of chemokine biosynthetic process • positive regulation of hormone biosynthetic process • positive regulation of interleukin-1 beta biosynthetic process • regulation of progesterone biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1958	13653
Ensembl	ENSG00000120738	ENSMUSG00000038418
UniProt	P18146	P08046
RefSeq (mRNA)	NM_001964	NM_007913
RefSeq (protein)	NP_001955	NP_031939
Location (UCSC)	Chr 5: 138.47 – 138.47 Mb	Chr 18: 34.86 – 34.86 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

Function

The protein encoded by this gene belongs to the EGR family of Cys₂His₂-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene.

It has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity.

EGR-1 has also been found to regulate the expression of VAMP2 (a protein important for synaptic exocytosis).

Structure

The DNA-binding domain of EGR-1 consists of three zinc finger domains of the Cys₂His₂ type. The amino acid structure of the EGR-1 zinc finger domain is given in this table, using the single letter amino acid code. The fingers 1 to 3 are indicated by f1 - f3. The numbers are in reference to the residues (amino acids) of alpha helix (there is no zero). The residues marked 'x' are not part of the zinc fingers, but rather serve to connect them all together.

-1

1

2

3

4

5

6

7

8

9

x

x

x

x

x

f1

M

A

E

E

R

P

Y

A

C

P

V

E

S

C

D

R

R

F

S

R

S

D

E

L

T

R

H

I

R

I

H

T

G

Q

K

P

f2

F

Q

C

A

I

-

-

C

M

R

N

F

S

R

S

D

H

L

T

T

H

I

A

T

H

T

G

E

K

P

f3

F

A

C

D

I

-

-

C

G

R

K

F

A

R

S

D

E

R

K

R

H

T

K

I

H

L

R

Q

K

D

Amino acid key: Alanine (Ala, A), Arginine (Arg, R), Asparagine (Asn, N), Aspartic acid (Asp, D), Cysteine (Cys, C), Glutamic acid (Glu, E), Glutamine (Gln, Q), Glycine (Gly, G), Histidine (His, H), Isoleucine (Ile, I), Leucine (Leu, L), Lysine (Lys, K), Methionine (Met, M), Phenylalanine (Phe, F), Proline (Pro, P), Serine (Ser, S), Threonine (Thr, T), Tryptophan (Trp, W), Tyrosine (Tyr, Y), Valine (Val, V)

The crystal structure of DNA bound by the zinc finger domain of EGR-1 was solved in 1991, which greatly aided early research in zinc finger DNA-binding domains.

The human EGR-1 protein contains (in its unprocessed form) 543 amino acids with a molecular weight of 57.5 kDa, and the gene is located on the chromosome 5.

DNA binding specificity

EGR-1 binds the DNA sequence 5'-GCG TGG GCG-3' (and similar ones like 5'-GCG GGG GCG-3'). The f1 position 6 binds the 5' G (the first base count from the left); the f1 position 3 to the second base (C); f1 position -1 binds to the third position (G); f2 position 6 to the fourth base (T); and so on.

Interactions

EGR-1 has been shown to interact with:

• CEBPB,
• CREB-binding protein,
• EP300,
• NAB1,
• P53, and
• PSMA3

See also

• Zinc finger

Further reading

• Heath RG (Mar 1975). "Brain function and behavior. I. Emotion and sensory phenomena in psychotic patients and in experimental animals". The Journal of Nervous and Mental Disease. 160 (3): 159–75. doi:10.1097/00005053-197503000-00002. PMID 1090709.
• Silverman ES, Collins T (Mar 1999). "Pathways of Egr-1-mediated gene transcription in vascular biology". The American Journal of Pathology. 154 (3): 665–70. doi:10.1016/S0002-9440(10)65312-6. PMC 1866415. PMID 10079243.
• Adamson ED, Mercola D (2002). "Egr1 transcription factor: multiple roles in prostate tumor cell growth and survival". Tumour Biology. 23 (2): 93–102. doi:10.1159/000059711. PMID 12065847.
• Blaschke F, Bruemmer D, Law RE (Aug 2004). "Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis". Reviews in Endocrine & Metabolic Disorders. 5 (3): 249–54. doi:10.1023/B:REMD.0000032413.88756.ee. PMID 15211096.
• Abdulkadir SA (Nov 2005). "Mechanisms of prostate tumorigenesis: roles for transcription factors Nkx3.1 and Egr1". Annals of the New York Academy of Sciences. 1059: 33–40. doi:10.1196/annals.1339.018. PMID 16382041.
• Khachigian LM (Feb 2006). "Early growth response-1 in cardiovascular pathobiology". Circulation Research. 98 (2): 186–91. doi:10.1161/01.RES.0000200177.53882.c3. PMID 16456111.

External links

• Zif+268+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook Egr-1

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 慢性腎疾患を有する小児における成長障害の予防およびマネージメント prevention and management of growth failure in children with chronic kidney disease
• 2. 慢性腎疾患を有する小児における成長障害の病因、評価および診断 pathogenesis evaluation and diagnosis of growth impairment in children with chronic kidney disease
• 3. 小児における成長ホルモン欠乏症の治療 treatment of growth hormone deficiency in children
• 4. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children
• 5. 成長ホルモンの生理学 physiology of growth hormone

English Journal

• Profile of stress and toxicity gene expression in human hepatic cells treated with Efavirenz.

• Gomez-Sucerquia LJ, Blas-Garcia A, Marti-Cabrera M, Esplugues JV, Apostolova N.SourceDepartamento de Farmacología, Facultad de Medicina, Universitat de València, Valencia, Spain; Fundación para la Investigación Hospital Universitario Dr. Peset, Valencia, Spain.
• Antiviral research.Antiviral Res.2012 Jun;94(3):232-41. Epub 2012 Apr 24.
• Hepatic toxicity and metabolic disorders are major adverse effects elicited during the pharmacological treatment of the human immunodeficiency virus (HIV) infection. Efavirenz (EFV), the most widely used non-nucleoside reverse transcriptase inhibitor (NNRTI), has been associated with these events, w
• PMID 22554935

• Absence of seasonal changes in FSHR gene expression in the cat cumulus-oocyte complex in vivo and in vitro.

• Hobbs RJ, Howard J, Wildt DE, Comizzoli P.SourceR Hobbs, Center for Species Survival, Smithsonian Conservation Biology Institute, Washington, United States.
• Reproduction (Cambridge, England).Reproduction.2012 May 28. [Epub ahead of print]
• Domestic cat oocytes are seasonally sensitive to follicle-stimulating hormone (FSH). Compared to those collected during the breeding season, oocytes from the non-breeding season require more FSH during in vitro maturation to achieve comparable developmental competence. The present study tested the
• PMID 22596062

Japanese Journal

• Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells

• Seki Sayaka,Aoki Miho,Hosokawa Toshiyuki,Saito Takeshi,Masuma Runa,Komori Miyako,Kurasaki Masaaki
• Chemico-Biological Interactions 194(1), 23-30, 2011-10-15
• … In this study, the morphological changes in nerve growth factor (NFG)-induced differentiation caused by bisphenol-A were confirmed using a PC12 cell system. …
• NAID 120003483496

• Transcription Factor-recognition Sequences Potentially Involved in Modulation of Gene Expression after Exposure to Low-dose-rate γ-rays in the Mouse Liver

• VARES Guillaume,UEHARA Yoshihiko,ONO Tetsuya,NAKAJIMA Tetsuo,WANG Bing,TAKI Keiko,MATSUMOTO Tsuneya,OGHISO Yoichi,TANAKA Kimio,ICHINOHE Kazuaki,NAKAMURA Shingo,TANAKA Satoshi,NENOI Mitsuru
• Journal of radiation research 52(2), 249-256, 2011-03-16
• … In this study, we used pre-existing microarray data and searched for gene modulations in response to long-term, low-dose-rate irradiation. … The binding sites for sterol regulatory element-binding protein 1 (SREBP-1), aryl hydrocarbon receptor (AhR/Ar) and olfactory 1 (Olf-1) were suggested to be involved in up-regulation, while the binding sites for glucocorticoid receptor (GR(GGTACAANNT GTYCTK) ) and hepatocyte nuclear factor 1 (HNF-1) were suggested to be involved in down-regulation of the genes. …
• NAID 10027956910

Related Links

• EGR1 - Wikipedia, the free encyclopedia

EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor.

• EARLY GROWTH RESPONSE PROTEIN 1 (HUMAN)

ChemicalBook あなたのためにEARLY GROWTH RESPONSE PROTEIN 1 ( HUMAN)の化学的性質を提供して、融点、価格、蒸気圧、沸点、毒性、比重、沸点、 密度、分子式、分子量、物理的な性質、毒性 税関のコードなどの情報、同時にあなたは ...

Related Pictures

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★リンクテーブル★

リンク元	「Egr-1」「初期増殖応答タンパク質1」
関連記事	「early」「grow」「response」「growth」「ear」

「Egr-1」

　　[★]

• 初期増殖応答タンパク質1

関

early growth response protein 1

「初期増殖応答タンパク質1」

　　[★]

英

early growth response protein 1、Egr-1

「early」

　　[★]

• adj.

• (比較級earlier-最上級earliest)早期の、初期の

• adv.

• 早く

関

archaic、beginning、early stage、early-stage、initial、initially、preterm、soon

　 　 　 　 　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「response」

　　[★]

• n.

• 返答、応答
• 反応、感応、反響。(刺激に対する)反応

　 　 　 　

「growth」

　　[★]

• n.

• 成長

　 　 　 　 　 　

「ear」

　　[★]

• n.

• 耳