WordNet

reason or establish by induction
cause to arise; "induce a crisis" (同)bring_on
produce electric current by electrostatic or magnetic processes (同)induct
cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
use recreational drugs (同)do drugs
administer a drug to; "They drugged the kidnapped tourist" (同)dose
a substance that is used as a medicine or narcotic
brought about or caused; not spontaneous; "a case of steroid-induced weakness"

PrepTutorEJDIC

〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 急性間質性腎炎の臨床症状および診断 clinical manifestations and diagnosis of acute interstitial nephritis
2. 非ステロイド性抗炎症剤（NSAIDs）：急性腎障害（急性腎不全） nsaids acute kidney injury acute renal failure
3. 成人における慢性腎臓病マネージメントの概要 overview of the management of chronic kidney disease in adults
4. 鎮痛剤性腎症の危険因子および病因 risk factors for and pathogenesis of analgesic nephropathy
5. 薬物誘発性ループス drug induced lupus

English Journal

Telmisartan ameliorates fibrocystic liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease.

Yoshihara D, Kugita M, Sasaki M, Horie S, Nakanishi K, Abe T, Aukema HM, Yamaguchi T, Nagao S.Author information Education and Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Aichi, Japan.AbstractHuman autosomal recessive polycystic kidney disease (ARPKD) produces kidneys which are massively enlarged due to multiple cysts, hypertension, and congenital hepatic fibrosis characterized by dilated bile ducts and portal hypertension. The PCK rat is an orthologous model of human ARPKD with numerous fluid-filled cysts caused by stimulated cellular proliferation in the renal tubules and hepatic bile duct epithelia, with interstitial fibrosis developed in the liver. We previously reported that a peroxisome proliferator activated receptor (PPAR)-γ full agonist ameliorated kidney and liver disease in PCK rats. Telmisartan is an angiotensin receptor blocker (ARB) used widely as an antihypertensive drug and shows partial PPAR-γ agonist activity. It also has nephroprotective activity in diabetes and renal injury and prevents the effects of drug-induced hepatotoxicity and hepatic fibrosis. In the present study, we determined whether telmisartan ameliorates progression of polycystic kidney and fibrocystic liver disease in PCK rats. Five male and 5 female PCK and normal control (+/+) rats were orally administered 3 mg/kg telmisartan or vehicle every day from 4 to 20 weeks of age. Treatment with telmisartan decreased blood pressure in both PCK and +/+ rats. Blood levels of aspartate amino transferase, alanine amino transferase and urea nitrogen were unaffected by telmisartan treatment. There was no effect on kidney disease progression, but liver weight relative to body weight, liver cystic area, hepatic fibrosis index, expression levels of Ki67 and TGF-β, and the number of Ki67- and TGF-β-positive interstitial cells in the liver were significantly decreased in telmisartan-treated PCK rats. Therefore, telmisartan ameliorates congenital hepatic fibrosis in ARPKD, possibly through the inhibition of signaling cascades responsible for cellular proliferation and interstitial fibrosis in PCK rats. The present results support the potential therapeutic use of ARBs for the treatment of fibrocystic liver disease in ARPKD patients.
PloS one.PLoS One.2013 Dec 6;8(12):e81480. doi: 10.1371/journal.pone.0081480.
Human autosomal recessive polycystic kidney disease (ARPKD) produces kidneys which are massively enlarged due to multiple cysts, hypertension, and congenital hepatic fibrosis characterized by dilated bile ducts and portal hypertension. The PCK rat is an orthologous model of human ARPKD with numerous
PMID 24324698

Utility of urine eosinophils in the diagnosis of acute interstitial nephritis.

Muriithi AK, Nasr SH, Leung N.Author information Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, †Department of Laboratory Medicine and Pathology. Mayo Clinic, Rochester, Minnesota.AbstractBACKGROUND AND OBJECTIVES: Urine eosinophils (UEs) have been shown to correlate with acute interstitial nephritis (AIN) but the four largest series that investigated the test characteristics did not use kidney biopsy as the gold standard.
Clinical journal of the American Society of Nephrology : CJASN.Clin J Am Soc Nephrol.2013 Nov;8(11):1857-62. doi: 10.2215/CJN.01330213. Epub 2013 Sep 19.
BACKGROUND AND OBJECTIVES: Urine eosinophils (UEs) have been shown to correlate with acute interstitial nephritis (AIN) but the four largest series that investigated the test characteristics did not use kidney biopsy as the gold standard.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This is a r
PMID 24052222

Granulomatous interstitial nephritis: Our experience of 14 patients.

Naidu GD, Ram R, Swarnalatha G, Uppin M, Prayaga AK, Dakshinamurty KV.Author information Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, India.AbstractGranulomatous interstitial nephritis (GIN) is a rare condition. Drugs, infections, immune processes, and foreign body reaction are the main causes. We identified a total of 14 patients with GIN during a period of 13 years in 2798 renal biopsies. There were 8 males and 6 females in the age range of 20-70 (mean 35 ± 12) years. The serum creatinine at presentation was 6.7 ± 3.8 (range: 2.3-14.7) mg/dl. In nine patients tuberculosis was the causative agent. Drugs (n = 2) and Wegener's granulomatosis (n = 1) were other etiologies. Systemic lupus erythematosis (SLE) and Immunoglobulin A nephropathy (IgAN) were seen in one patient each. Patients with tuberculosis were treated with antituberculous therapy and three of them improved. Four out of six patients who required dialysis at presentation remained dialysis dependent, one of whom underwent renal transplantation. Two patients progressed to end stage renal disease after 7 years and 9 years each. The patients with drug induced GIN had improvement in renal function after prednisolone treatment. Patients with SLE, and Wegener's granulomatosis responded to immunosuppression. Patient with IgAN was on conservative management. Finally, six patients were on conservative management for chronic renal failure.
Indian journal of nephrology.Indian J Nephrol.2013 Nov;23(6):415-8. doi: 10.4103/0971-4065.120336.
Granulomatous interstitial nephritis (GIN) is a rare condition. Drugs, infections, immune processes, and foreign body reaction are the main causes. We identified a total of 14 patients with GIN during a period of 13 years in 2798 renal biopsies. There were 8 males and 6 females in the age range of 2
PMID 24339518

Japanese Journal

Chronic Hepatitis B with Fanconi's Syndrome Triggered by Short-term Administration of Adefovir Dipivoxil

Takatori Masao,Iwabuchi Shogo,Shimizu Hirohito [他],Takatsuka Kentaro,Matsui Keiji,Fujikawa Tomoaki,Matsunaga Kotaro,Okuse Chiaki
Journal of St. Marianna University 6(1), 71-75, 2015
… Serum HBV DNA gradually decreased over 7 -months of this drug substitution; … Since he was suspected as having drug-induced liver damage and nephropathy caused by NAs, ADV and ETV were administered every other day for 3 months, resulting in no improvement. … Thus, we suggested that he suffered from acquired Fanconi's syndrome induced by ADV. …
NAID 130005085597

糖尿病性腎症をもつ生体肝移植症例に対してMycophenolate Mofetilを基本とした免疫抑制療法で導入した一例

倉光正太郎,井口友宏,二宮瑞樹,山下洋市,播本憲史,池上徹,内山秀昭,吉住朋晴,副島雄二,調憲,川中博文,池田哲夫,古田斗志也,玉田隆一郎,前原喜彦
Fukuoka Acta Medica 105(3), 79-83, 2013-12-25
… A 62-year-old woman with ecompensated liver cirrhosis secondary to hepatitis B (Child-Pugh C, MELD score 11points) and chronic renal failure due to diabetic nephropathy (Cr 1.56mg/dl, GFR 27ml/min/1.73m^2) experienced LDLT. …
NAID 120005438027

インターフェロンβ-1b 長期治療中にネフローゼ症候群を合併した多発性硬化症の 2 例

池田謙輔,岡本智子,山村隆,大澤勲,古寺理恵,村田美穂
臨床神経学 53(1), 19-23, 2013
症例1 は 59 歳の男性で 40 歳時に多発性硬化症を発症，51 歳時からインターフェロンβ-1b 治療を開始され，8 年後にネフローゼ症候群を発症した．症例2 は 33 歳の女性で 15 歳時に多発性硬化症を発症，26 歳時からインターフェロンβ-1b 治療を開始され，7 年後にネフローゼ症候群を発症した．両者とも二次性膜性腎症の病理像であり，インターフェロンβ-1b による薬剤性ネフローゼ症 …
NAID 130004505297