関: bucladesine、db-cAMP、dbcAMP

WordNet

of a compound having atoms arranged in a ring structure
recurring in cycles (同)cyclical
conforming to the Carnot cycle
forming a whorl or having parts arranged in a whorl; "cyclic petals"; "cyclic flowers"
marked by repeated cycles
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

answer / ampere

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/11 21:05:13」(JST)

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Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.

Bucladesine is a cell permeable cAMP analog. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions. cAMP is only able to elicit minimal responses in these situations.

The neurite outgrowth instigated by bucladesine in cell cultures has been shown to be enhanced by nardosinone.

External links[edit]

Bucladesine at the US National Library of Medicine Medical Subject Headings (MeSH)

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

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English Journal

Sulfonylurea receptor-1, sulfonylureas, and amplification of insulin secretion by Epac activation in β-cells.

Nenquin M1, Henquin JC1.
Diabetes, obesity & metabolism.Diabetes Obes Metab.2015 Nov 20. doi: 10.1111/dom.12607. [Epub ahead of print]
Amplification of insulin secretion by cyclic AMP involves activation of protein kinase A and Epac2 in pancreatic β-cells. Recent hypotheses suggest that sulfonylurea receptor-1 (SUR1), the regulatory subunit of ATP-sensitive potassium channels, is implicated in Epac2 effects and that direct activat
PMID 26584950

Selective enhancement of wnt4 expression by cyclic AMP-associated cooperation between rat central astrocytes and microglia.

Ohnishi M1, Urasaki T2, Ochiai H3, Matsuoka K3, Takeo S3, Harada T3, Ohsugi Y3, Inoue A4.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Nov 13;467(2):367-72. doi: 10.1016/j.bbrc.2015.09.151. Epub 2015 Sep 30.
The wnt protein family has important members involved in cell differentiation, proliferation and plasticity expression; however, little is known about its biosynthesis processes. On the other hand, an increase in the intracerebral cyclic adenosine 3', 5'-monophosphate (cAMP) level leads to synaptic
PMID 26431871

Functional upregulation of the H2S/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells.

Fukami K1, Sekiguchi F2, Yasukawa M3, Asano E4, Kasamatsu R5, Ueda M6, Yoshida S7, Kawabata A8.
Biochemical pharmacology.Biochem Pharmacol.2015 Oct 1;97(3):300-9. doi: 10.1016/j.bcp.2015.08.005. Epub 2015 Aug 7.
Neuroendocrine-differentiated prostate cancer cells may contribute to androgen-independent proliferation of surrounding cells through Ca(2+)-dependent secretion of mitogenic factors. Human prostate cancer LNCaP cells, when neuroendocrine-differentiated, overexpress Cav3.2 T-type Ca(2+) channels that
PMID 26256074

Japanese Journal

Successful Piglet Production in a Chemically Defined System for In-vitro Production of Porcine Embryos : Dibutyryl Cyclic AMP and Epidermal Growth Factor-family Peptides Support In-vitro Maturation of Oocytes in the Absence of Gonadotropins

AKAKI Yuka,YOSHIOKA Koji,NOGUCHI Michiko,HOSHI Hiroyoshi,FUNAHASHI Hiroaki
The Journal of reproduction and development 55(4), 446-453, 2009-08-01
… The present study was undertaken to examine the combinational effects of epidermal growth factor (EGF)-family members and dibutyryl cyclic AMP (cAMP) in a chemically defined medium on IVM of porcine oocytes and the developmental competence following in vitro fertilization (IVF). …
NAID 10025194548

Effect of Vanadate on the Chromatin Configuration in Pig GV-oocytes

BUI Hong-Thuy,HWANG Kyu-Chan,KIM Jin-Hoi,VAN THUAN Nguyen,WAKAYAMA Teruhiko,MIYANO Takashi
The Journal of reproduction and development 55(4), 367-372, 2009-08-01
… The effect of vanadate and hMG on chromatin configuration could be replicated with 2 mM dibutyryl cyclic AMP (dbcAMP) in place of hMG. …
NAID 10025194108

Related Pictures

★リンクテーブル★

リンク元	「ブクラデシン」「ジブチリル環状AMP」「db-cAMP」「dbcAMP」「ジブチリルサイクリックAMP」
関連記事	「cyclic」「A」「AM」「AMP」「cyclic AMP」

「ブクラデシン」

Bucladesine
Systematic (IUPAC) name
	sodium (3aR,4R,6R,6aR)-4-(6-butanamido-9H-purin-9-yl)-6-[(butanoyloxy)methyl]-2-oxo-tetrahydro-2H-1,3,5,2λ5-furo[3,4-d][1,3,2]dioxaphosphol-2-olate
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	362-74-3
ATC code	C01CE04
PubChem	CID 28177
ChemSpider	9306
UNII	63X7MBT2LQ
ChEBI	CHEBI:50095
ChEMBL	CHEMBL485980
Synonyms	• Dibutyryl cyclic adenosine monophosphate; • (N6,2'-O-dibutyryl)-adenosine-3',5'-mono-phosphate; • Dibutyryl cAMP; • DcAMP; • DBcAMP
Chemical data
Formula	C18H23N5NaO8P
Mol. mass	491.368 g/mol
	SMILES O=C(Nc4ncnc1c4ncn1[C@@H]2O[C@@H]3COP(=O)(O[C@H]3[C@H]2OC(=O)CCC)O)CCC;
	InChI InChI=1S/C18H24N5O8P/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24)/t10-,14-,15-,18-/m1/s1 ; Key:CJGYSWNGNKCJSB-YVLZZHOMSA-N ;
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