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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/25 12:00:25」(JST)

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Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor.

Bucladesine is a cell permeable cAMP analog. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions. cAMP is only able to elicit minimal responses in these situations.

The neurite outgrowth instigated by bucladesine in cell cultures has been shown to be enhanced by nardosinone.

External links

Bucladesine at the US National Library of Medicine Medical Subject Headings (MeSH)

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

English Journal

Reduction of autophagy markers mediated protective effects of JNK inhibitor and bucladesine on memory deficit induced by Aβ in rats.

Mohammadi M1, Guan J2,3,4, Khodagholi F5,6, Yans A5,6, Khalaj S1, Gholami M1, Taghizadeh GH1,7, Aliaghaei A8, Abdollahi M1, Ghahremani MH1, Sharifzadeh M9,10.
Naunyn-Schmiedeberg's archives of pharmacology.Naunyn Schmiedebergs Arch Pharmacol.2016 Feb 22. [Epub ahead of print]
Autophagy, the process of self-degradation of cellular components, has an important role in neurodegenerative diseases, such as Alzheimer's disease. In this study, we investigated the effects of SP600125 as c-Jun N-terminal kinase (JNK) inhibitor and bucladesine as a cyclic adenosine 3',5'-monophosp
PMID 26899864

Abdominal adipocyte populations in women with visceral obesity.

Michaud A1, Laforest S1, Pelletier M2, Nadeau M2, Simard S2, Daris M2, Lebœuf M2, Vidal H2, Géloën A2, Tchernof A3.
European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2016 Feb;174(2):227-39. doi: 10.1530/EJE-15-0822. Epub 2015 Nov 17.
BACKGROUND: Visceral obesity is independently related to numerous cardiometabolic alterations, with adipose tissue dysfunction as a central feature.OBJECTIVE: To examine whether omental (OM) and subcutaneous (SC) adipocyte size populations in women relate to visceral obesity, cardiometabolic risk fa
PMID 26578637

Organophosphate Flame Retardants act as Endocrine-Disrupting Chemicals in MA-10 Mouse Tumor Leydig Cells.

Schang G1, Robaire B2, Hales BF1.
Toxicological sciences : an official journal of the Society of Toxicology.Toxicol Sci.2016 Jan 21. pii: kfw012. [Epub ahead of print]
The organophosphate flame retardants (OPFRs) have emerged as alternatives to banned brominated flame retardants but little is known about their possible activity as endocrine disruptors. Our goal was to compare the effects of seven commonly used OPFRs in vitro on MA-10 mouse Leydig tumor cells to th
PMID 26794138

Japanese Journal

Long-Term Exposure of RN46A Cells Expressing Serotonin Transporter (SERT) to a cAMP Analog Up-regulates SERT Activity and Is Accompanied by Neural Differentiation of the Cells

Yammamoto Hikaru,Tanaka Shigeru,Tanaka Anna,Hide Izumi,Seki Takahiro,Sakai Norio
Journal of Pharmacological Sciences, 2012
… To examine the functional regulation of serotonin transporter (SERT) by cAMP, we examined whether SERT uptake activity was affected by dibutyryl cAMP (dbcAMP), a cAMP analog, in SERT-transfected RN46A cells derived from embryonic rat raphe neurons. … 4 h) of dbcAMP (1 mM) to SERT-expressing RN46A cells significantly up-regulated SERT activity. … Time-dependent up-regulation of SERT activity by dbcAMP was accompanied by neural differentiation of RN46A cells. …
NAID 130002507905

Effects of Preservation of Porcine Oocytes by Dibutyryl Cyclic AMP on in vitro Maturation, Fertilization and Development

FUCHIMOTO Dai-ichiro,SENBON Shoichiro,SUZUKI Shunichi,ONISHI Akira
Japan Agricultural Research Quarterly: JARQ 45(3), 295-300, 2011
… In this study, the effects of dibutyryl cyclic AMP (dbcAMP) on the preservation of porcine oocytes were investigated. … Oocytes were preserved for 24 h or 48 h in modified NCSU37 supplemented with or without 1 mM dbcAMP. … After the preservation, 98.3% and 95.2% of oocytes incubated with dbcAMP for 24 h and 48 h, respectively, were at the germinal vesicle stage, whereas about a half of the oocytes incubated without dbcAMP underwent germinal vesicle break down. …
NAID 130002147942

「ブクラデシン」

Bucladesine
Systematic (IUPAC) name
	sodium (3aR,4R,6R,6aR)-4-(6-butanamido-9H-purin-9-yl)-6-[(butanoyloxy)methyl]-2-oxo-tetrahydro-2H-1,3,5,2λ5-furo[3,4-d][1,3,2]dioxaphosphol-2-olate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	362-74-3
ATC code	C01CE04
PubChem	CID 28177
ChemSpider	9306
UNII	63X7MBT2LQ
ChEBI	CHEBI:50095
ChEMBL	CHEMBL485980
Synonyms	• Dibutyryl cyclic adenosine monophosphate; • (N6,2'-O-dibutyryl)-adenosine-3',5'-mono-phosphate; • Dibutyryl cAMP; • DcAMP; • DBcAMP
Chemical data
Formula	C18H23N5NaO8P
Mol. mass	491.368 g/mol
	SMILES O=C(Nc4ncnc1c4ncn1[C@@H]2O[C@@H]3COP(=O)(O[C@H]3[C@H]2OC(=O)CCC)O)CCC;
	InChI InChI=1S/C18H24N5O8P/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24)/t10-,14-,15-,18-/m1/s1 ; Key:CJGYSWNGNKCJSB-YVLZZHOMSA-N ;
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