WordNet

(biochemistry) a nucleoside that is a structural component of nucleic acids; it is present in all living cells in a combined form as a constituent of DNA and RNA and ADP and ATP and AMP

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/04 19:17:36」(JST)

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Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.

Production and degradation

AMP can be produced during ATP synthesis by the enzyme adenylate kinase by combining two ADP molecules:

2 ADP → ATP + AMP

Or AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP:

ADP → AMP + P_i

AMP can also be formed by hydrolysis of ATP into AMP and pyrophosphate:

ATP → AMP + PP_i

When RNA is broken down by living systems, nucleoside monophosphates, including adenosine monophosphate, are formed.

AMP can be regenerated to ATP as follows:

AMP + ATP → 2 ADP (adenylate kinase in the opposite direction)

ADP + P_i → ATP (this step is most often performed in aerobes by the ATP synthase during oxidative phosphorylation)

AMP can be converted into IMP by the enzyme myoadenylate deaminase, freeing an ammonia group.

In a catabolic pathway, adenosine monophosphate can be converted to uric acid, which is excreted from the body.

cAMP

AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes cAMP from ATP, and typically this reaction is regulated by hormones such as adrenaline or glucagon. cAMP plays an important role in intracellular signaling.

References

External links

GMD MS Spectrum
Ming D, Ninomiya Y, Margolskee RF (1999). "Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds". Proc. Natl. Acad. Sci. USA 96 (17): 9903–9908. doi:10.1073/pnas.96.17.9903. PMC 22308. PMID 10449792.

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「アデノシン一リン酸」

Adenosine monophosphate
Names
	IUPAC name [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
	Other names Adenosine 5'-monophosphate, 5'-Adenylic acid
Identifiers
CAS Number	61-19-8
ChEBI	CHEBI:16027
ChEMBL	ChEMBL752
ChemSpider	5858
DrugBank	DB00131
	InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 Key: UDMBCSSLTHHNCD-KQYNXXCUSA-N ; InChI=1/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 Key: UDMBCSSLTHHNCD-KQYNXXCUBP ;
IUPHAR/BPS	2455
Jmol interactive 3D	Image; Image
KEGG	C00020
MeSH	Adenosine+monophosphate
PubChem	6083
	SMILES O=P(O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3O ; c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N ;
UNII	415SHH325A
Properties
Chemical formula	C10H14N5O7P
Molar mass	347.22 g/mol
Appearance	white crystalline powder
Density	2.32 g/mL
Melting point	178 to 185 °C (352 to 365 °F; 451 to 458 K)
Boiling point	798.5 °C (1,469.3 °F; 1,071.7 K)
Acidity (pKa)	0.9, 3.8, 6.1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: adenosine monophosphate adenosine 5'-monophosphate AMP
同: アデニル酸 5'-アデニル酸 adenylate adenylic acid 5'-adenylic acid
関: チミン

「adenylate」

　　[★]

n.

アデニル酸

v.

アデニル化する

関: adenosine monophosphate、adenylation、adenylic acid

「AMP」

　　[★] アデノシン一リン酸 adenosine monophosphate adenosine 5'-monophosphate

「8-bromo cyclic adenosine monophosphate」

　　[★]

8-ブロモサイクリックアデノシン一リン酸

関: 8-bromo cyclic AMP、8-bromo-cAMP

「deoxyadenosine monophosphate」

　　[★]

デオキシアデノシン一リン酸、デオキシアデニル酸

関: dAMP

「cyclic adenosine monophosphate」

　　[★] 環状アデノシン一リン酸

「monophosphate」

　　[★]

n.

一リン酸塩、一リン酸エステル、一リン酸

リンク元	「アデノシン一リン酸」「adenylate」「AMP」
拡張検索	「8-bromo cyclic adenosine monophosphate」「deoxyadenosine monophosphate」「cyclic adenosine monophosphate」
関連記事	「monophosphate」

匿名

検索

案内

案内

adenosine monophosphate