decay accelerating factor

崩壊促進因子 DAF

WordNet

1. undergo decay or decomposition; "The body started to decay and needed to be cremated"
2. fall into decay or ruin; "The unoccupied house started to decay" (同)crumble, dilapidate
3. a gradual decrease; as of stored charge or current (同)decline
4. the organic phenomenon of rotting (同)decomposition
5. the spontaneous disintegration of a radioactive substance along with the emission of ionizing radiation (同)radioactive decay, disintegration
6. an inferior state resulting from the process of decaying; "the corpse was in an advanced state of decay"; "the house had fallen into a serious state of decay and disrepair"
7. the process of gradually becoming inferior
8. be a contributing factor; "make things factor into a companys profitability"
9. any of the numbers (or symbols) that form a product when multiplied together
10. an independent variable in statistics
11. anything that contributes causally to a result; "a number of factors determined the outcome"
12. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
13. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
14. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
15. a concept whose truth can be proved; "scientific hypotheses are not facts"
16. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
17. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
18. damaged by decay; hence unsound and useless; "rotten floor boards"; "rotted beams"; "a decayed foundation" (同)rotten, rotted

PrepTutorEJDIC

1. 『腐る』,朽ちる / 〈繁栄・健康などが〉『衰える』,衰退する;〈活力などが〉低下する / 〈他〉 / …'を'『腐らせる』 / 『腐敗』;腐朽 / 『衰微』,衰え / (放射性物質の)自然崩壊
2. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
3. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/10 12:02:58」(JST)

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[Wiki en表示]

CD55 molecule, decay accelerating factor for complement (Cromer blood group)
PDB rendering based on 1h03.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1H03, 1H04, 1H2P, 1H2Q, 1M11, 1NWV, 1OJV, 1OJW, 1OJY, 1OK1, 1OK2, 1OK3, 1OK9, 1UOT, 1UPN, 2C8I, 2QZD, 2QZF, 2QZH, 3IYP, 3J24
Identifiers
Symbols	CD55; CR; CROM; DAF; TC
External IDs	OMIM: 125240 MGI: 104850 HomoloGene: 479 GeneCards: CD55 Gene
Gene Ontology Molecular function • enzyme inhibitor activity Cellular component • extracellular region • plasma membrane • integral to plasma membrane • cell surface • apical plasma membrane • anchored to membrane • membrane raft Biological process • complement activation, classical pathway • elevation of cytosolic calcium ion concentration • spermatogenesis • regulation of complement activation • response to peptide hormone stimulus • innate immune response • respiratory burst • negative regulation of complement activation • maternal process involved in parturition Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1604	13136
Ensembl	ENSG00000196352	ENSMUSG00000026399
UniProt	P08174	Q3TU32
RefSeq (mRNA)	NM_000574	NM_010016
RefSeq (protein)	NP_000565	NP_034146
Location (UCSC)	Chr 1: 207.49 – 207.53 Mb	Chr 1: 132.27 – 132.29 Mb
PubMed search	[1]	[2]

Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene.

Decay accelerating factor is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

Pathology

Paroxysmal nocturnal hemoglobinuria

Because DAF is a GPI-anchored protein, its expression is reduced in persons with mutations that reduce GPI levels such as those with paroxysmal nocturnal hemoglobinuria; in that disorder, RBCs with very low levels of DAF and CD59 undergo complement-mediated hemolysis.

Infectious diseases

DAF is used as a receptor by some coxsackieviruses and other enteroviruses. Recombinant soluble DAF-Fc has been tested in mice as an anti-enterovirus therapy for heart damage; however, the human enterovirus that was tested binds much more strongly to human DAF than to mouse or rat DAF. Echoviruses and coxsackie B viruses that use human decay-accelerating factor (DAF) as a receptor do not bind the rodent analogues of DAF. and DAF-Fc has yet to be tested in humans.

See also

• List of human clusters of differentiation
• CD59

References

Further reading

• Selinka HC, Wolde A, Sauter M, et al. (2004). "Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism.". Med. Microbiol. Immunol. 193 (2-3): 127–31. doi:10.1007/s00430-003-0193-y. PMID 12920584. 
• Mikesch JH, Schier K, Roetger A, et al. (2007). "The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy.". Cell. Oncol. 28 (5-6): 223–32. PMID 17167176. 

External links

• Decay-Accelerating Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
• Cromer blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 発作性夜間血色素尿症の病因 pathogenesis of paroxysmal nocturnal hemoglobinuria
• 2. 補体系の遺伝性疾患 inherited disorders of the complement system
• 3. 補体系の制御因子および受容体 regulators and receptors of the complement system
• 4. 母体 - 胎児接点の免疫 immunology of the maternal fetal interface
• 5. 心筋炎の病因および発症機序 etiology and pathogenesis of myocarditis

English Journal

• The African-387 C>T TGFB1 variant is functional and associates with the ophthalmoplegic complication in juvenile myasthenia gravis.

• Nel M1, Buys JM1, Rautenbach R1, Mowla S2, Prince S3, Heckmann JM1.
• Journal of human genetics.J Hum Genet.2015 Dec 3. doi: 10.1038/jhg.2015.146. [Epub ahead of print]
• Although extraocular muscles are commonly affected by myasthenia gravis (MG) at presentation, a treatment-resistant ophthalmoplegic complication of MG (OP-MG) occurs in younger patients with African-genetic ancestry. In MG, pathogenic antibodies activate complement-mediated muscle damage and this ma
• PMID 26632886

• Enterovirus strain and type-specific differences in growth kinetics and virus-induced cell destruction in human pancreatic duct epithelial HPDE cells.

• Smura T1, Natri O2, Ylipaasto P3, Hellman M2, Al-Hello H3, Piemonti L4, Roivainen M3.
• Virus research.Virus Res.2015 Dec 2;210:188-97. doi: 10.1016/j.virusres.2015.08.003. Epub 2015 Aug 7.
• Enterovirus infections have been suspected to be involved in the development of type 1 diabetes. However, the pathogenetic mechanism of enterovirus-induced type 1 diabetes is not known. Pancreatic ductal cells are closely associated with pancreatic islets. Therefore, enterovirus infections in ductal
• PMID 26260332

• Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins.

• Gautam AK1, Panse Y1, Ghosh P2, Reza MJ1, Mullick J3, Sahu A4.
• Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Oct 13;112(41):12794-9. doi: 10.1073/pnas.1506449112. Epub 2015 Sep 29.
• The complement system has evolved to annul pathogens, but its improper regulation is linked with diseases. Efficient regulation of the system is primarily provided by a family of proteins termed regulators of complement activation (RCA). The knowledge of precise structural determinants of RCA protei
• PMID 26420870

Japanese Journal

• GPI-アンカー型HRP融合タンパク質を用いるEMARS法による脂質ラフトの分別

• Trends in Glycoscience and Glycotechnology 26(149), 59-69, 2014
• NAID 130004841383

• Expression of Membrane Complement Regulatory Proteins Crry and CD55 in Normal Rats

• Journal of Toxicologic Pathology 26(2), 223-226, 2013
• NAID 130003362373

• 体細胞クローン技術の高度化および遺伝子組換えブタの維持・保存に関する研究開発

• 茨城県畜産センター研究報告 (46), 35-39, 2012-10
• NAID 120005451408

Related Links

• Decay-accelerating factorとは - goo Wikipedia (ウィキペディア)

Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. [1] Decay accelerating factor is a 70 kDa membrane protein that regulates the complement system on ...

• Decay accelerating factor - definition of Decay accelerating ...

factor [fak´ter] an agent or element that contributes to the production of a result. accelerator factor factor V, one of the coagulation factors. factor I see coagulation factors. factor II see coagulation factors. factor III see coagulation ...

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★リンクテーブル★

リンク元	「崩壊促進因子」「DAF」
拡張検索	「decay-accelerating factor」
関連記事	「decay」「fact」「factor」「accelerating」

「崩壊促進因子」

　　[★]

英

decay-accelerating factor, decay accelerating factor, DAF

同

CD55抗原、CD55

関

CD59、発作性夜間血色素尿症

「DAF」

　　[★] 崩壊促進因子, decay-accelerating factor, decay accelerating factor

「decay-accelerating factor」

　　[★] 崩壊促進因子 DAF CD55

「decay」

　　[★]

• vi

• 腐食する
• 衰える、減衰する。(理)(放射性物質・素粒子・原子核が)(自然)崩壊する

• vt.

• 朽ちさせる、腐蝕する。腐敗させる

• n.

• 腐食、腐朽、腐敗。(歯の)齲蝕、むしば。腐食部、腐敗した物質
• 減衰、衰弱、衰退、老朽化。(理)(放射性物質・素粒子・原子核の)崩壊。(電流の)減少、(磁束の)減衰、(電荷などの)消失。

　 　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「accelerating」

　　[★]

• adj.

• 加速度的な、促進的な

関

accelerated、acceleratingly、acceleratory、facilitatory、promotional