膠原病
WordNet
- an impairment of health or a condition of abnormal functioning
- a soft thin (usually translucent) paper (同)tissue_paper
- part of an organism consisting of an aggregate of cells having a similar structure and function
- connecting or tending to connect; "connective remarks between chapters"; "connective tissue in animals"; "conjunctive tissue in plants"
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
PrepTutorEJDIC
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper
- 結びつける,連結の,接続の / 連結辞(接続詞・関係代名詞など)
- 病気にかかった / 病的な,不健全な(morbid)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/25 22:13:54」(JST)
[Wiki en表示]
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This section relies largely or entirely upon a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources. (March 2013) |
| Connective tissue disease |
| Classification and external resources |
| MedlinePlus |
001223 |
| MeSH |
D003240 |
A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs. These tissues form a framework, or matrix, for the body, and are composed of two major structural protein molecules: collagen and elastin. There are many different types of collagen protein in each of the body's tissues. Elastin has the capability of stretching and returning to its original length—like a spring or rubber band. Elastin is the major component of ligaments (tissues that attach bone to bone) and skin. In patients with connective tissue disease, it is common for collagen and elastin to become injured by inflammation. Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune system that is directed against one's own body tissues (autoimmunity).[1]
Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. Collagen vascular diseases can be (but are not necessarily) associated with collagen and blood vessel abnormalities and that are autoimmune in nature.[1] See also vasculitis.
Connective tissue diseases can have strong or weak inheritance risks, and can also be caused by environmental factors.
Contents
- 1 Heritable connective tissue disorders
- 2 Autoimmune connective tissue disorders
- 3 Other connective tissue disorders
- 4 References
- 5 External links
Heritable connective tissue disorders
- Marfan syndrome – a genetic disease causing abnormal fibrillin.
- Peyronie's disease- involving the growth of abnormal collagen (Type I and III) in the penis.
- Ehlers-Danlos syndrome – defect in the synthesis of collagen (Type I or III) causes progressive deterioration of collagens, with different EDS types affecting different sites in the body, such as joints, heart valves, organ walls, arterial walls
- Osteogenesis imperfecta (brittle bone disease) – caused by insufficient production of normal collagen (primarily type I) to produce healthy, strong bones.
- Stickler syndrome – affects collagen (primarily type II and XI), and may result in a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems.
- Alport syndrome - defects in collagen (type IV), found in the renal basement membrane, inner ear and eyes, leading to glomerulonephritis, hearing loss, and eye disease, respectively.
- Congenital contractural arachnodactyly - Also known as Beal's syndrome. It is akin to Marfan syndrome but with Contractures of hip, knee, elbows and ankle joint and crumpled ear.
Autoimmune connective tissue disorders
Main article: Autoimmunity
These are also referred to as systemic autoimmune diseases. The autoimmune CTDs may have both genetic and environmental causes. Genetic factors may create a predisposition towards developing these autoimmune diseases. They are characterized as a group by the presence of spontaneous overactivity of the immune system that results in the production of extra antibodies into the circulation. The classic collagen vascular diseases have a "classic" presentation with typical findings that doctors can recognize during an examination. Each also has "classic" blood test abnormalities and abnormal antibody patterns. However, each of these diseases can evolve slowly or rapidly from very subtle abnormalities before demonstrating the classic features that help in the diagnosis. The classic collagen vascular diseases include:
- Systemic lupus erythematosus (SLE) – An inflammation of the connective tissues, SLE can afflict every organ system. It is up to nine times more common in women than men and strikes black women three times as often as white women. The condition is aggravated by sunlight.
- Rheumatoid arthritis – Rheumatoid arthritis is a systemic disorder in which immune cells attack and inflame the membrane around joints. It also can affect the heart, lungs, and eyes. Of the estimated 2.1 million Americans with rheumatoid arthritis, approximately 1.5 million (71 percent) are women.
- Scleroderma – an activation of immune cells that produces scar tissue in the skin, internal organs, and small blood vessels. It affects women three times more often than men overall, but increases to a rate 15 times greater for women during childbearing years, and appears to be more common among black women.
- Sjögren's syndrome – also called Sjögren's disease, is a chronic, slowly progressing inability to secrete saliva and tears. It can occur alone or with rheumatoid arthritis, scleroderma, or systemic lupus erythematosus. Nine out of 10 cases occur in women, most often at or around mid-life.
- Mixed connective tissue disease – Mixed connective-tissue disease (MCTD) is a disorder in which features of various connective-tissue diseases (CTDs) such as systemic lupus erythematosus (SLE); systemic sclerosis (SSc); dermatomyositis (DM); polymyositis (PM); anti-synthetase syndrome; and, occasionally, Sjögren syndrome can coexist and overlap. The course of the disease is chronic and usually milder than other CTDs. In most cases, MCTD is considered an intermediate stage of a disease that eventually becomes either SLE or Scleroderma.
- Psoriatic arthritis is also a collagen vascular disease.[2]
Other connective tissue disorders
- Scurvy – caused by a dietary deficiency in vitamin C, leading to abnormal collagen.
References
- ^ a b William C. Shiel Jr.,Connective Tissue Disease
- ^ Medline Plus, Collagen vascular disease.
External links
- Merck Manual: Musculoskeletal and connective tissue disorders
- Merck Manual: Inherited connective tissue disorders
- Arthritis Foundation
- The Myositis Foundation
- What the heck is a connective tissue disease?
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Systemic connective tissue disorders (M32–M36, 710)
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| General |
| Systemic lupus erythematosus: |
- Drug-induced SLE
- Libman-Sacks endocarditis
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| Inflammatory myopathy/Myositis: |
- Dermatopolymyositis
- Dermatomyositis/Juvenile dermatomyositis
- Polymyositis* Inclusion body myositis
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| Scleroderma: |
- Systemic scleroderma
- Progressive systemic sclerosis
- CREST syndrome
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- Overlap syndrome / Mixed connective tissue disease
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| Other hypersensitivity/autoimmune |
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| Other |
- Behçet's disease
- Polymyalgia rheumatica
- Eosinophilic fasciitis
- Eosinophilia–myalgia syndrome
- fibrillin
- Marfan syndrome
- Congenital contractural arachnodactyly
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| Description |
- Anatomy
- head
- neck
- arms
- chest and back
- diaphragm
- abdomen
- genital area
- legs
- Muscle tissue
- Physiology
- Development
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| Disease |
- Myopathy
- Soft tissue
- Connective tissue
- Congenital
- Neoplasms and cancer
- Injury
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- anti-inflammatory
- muscle relaxants
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UpToDate Contents
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English Journal
- Effects of Elaeagnus angustifolia L. on Lipid Profile and Atherogenic Indices in Obese Females: A Randomized Controlled Clinical Trial.
- Nikniaz Z1, Mahdavi R2, Nikniaz L3, Ebrahimi A4, Ostadrahimi A2.
- Journal of dietary supplements.J Diet Suppl.2016 Nov;13(6):595-606. doi: 10.3109/19390211.2016.1150933. Epub 2016 Mar 1.
- In the present randomized double-blinded placebo-controlled study, the effect of Elaeagnus angustifolia L. (EA) whole fruit and medulla powders on anthropometric indices, serum lipid profile, and atherogenic indices in females with knee osteoarthritis (OA) was investigated. Ninety females with mild
- PMID 26930244
- Muscle-bone interactions: From experimental models to the clinic? A critical update.
- Laurent MR1, Dubois V2, Claessens F2, Verschueren SM3, Vanderschueren D4, Gielen E5, Jardí F4.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2016 Sep 5;432:14-36. doi: 10.1016/j.mce.2015.10.017. Epub 2015 Oct 23.
- Bone is a biomechanical tissue shaped by forces from muscles and gravitation. Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco-osteoporosis) is seen in ageing, numerous clinical situations including after stroke or paralysis, in neuromuscular dystrophies, glucocorticoid e
- PMID 26506009
- The role of matrix metalloproteinases in muscle and adipose tissue development and meat quality: A review.
- Christensen S1, Purslow PP2.
- Meat science.Meat Sci.2016 Sep;119:138-46. doi: 10.1016/j.meatsci.2016.04.025. Epub 2016 Apr 21.
- Matrix metalloproteinases (MMPs) are a group of enzymes that degrade extracellular matrix components but are also important signaling molecules that regulate many biological processes including muscle, adipose and connective tissue development. Most recently it has been discovered that MMPs act as i
- PMID 27180222
Japanese Journal
- MCTDに合併する呼吸器疾患 (特集 膠原病に合併する呼吸器疾患)
Related Links
- A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects ...
- Read about causes, symptoms, types, and diagnosis of connective tissue diseases like systemic lupus, scleroderma, polymyositis, dermatomyositis, Marfan syndrome, rheumatoid arthritis, and Ehlers-Danlos syndrome.
Related Pictures
★リンクテーブル★
[★]
- 英
- connective tissue disease
- 関
- 膠原病、結合組織病
[★]
膠原病
- 関
- collagen disease、connective tissue disease
[★]
膠原病。connective tissue disease
[★]
混合性結合組織病 MCTD
[★]
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 関
- ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness
- disease ≠ illness ≠ disorder
[★]
- 関
- affinity、binding、bonding、connectivity、symphysic