関: collagen disease、connective tissue disease

WordNet

bring disorder to (同)disarray
a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time" (同)upset
a disturbance of the peace or of public order
a paste-up made by sticking together pieces of paper or photographs to form an artistic image; "he used his computer to make a collage of pictures superimposed on a map" (同)montage
any collection of diverse things; "a collage of memories"
a fibrous scleroprotein in bone and cartilage and tendon and other connective tissue; yields gelatin on boiling
not arranged in order (同)unordered

PrepTutorEJDIC

〈U〉『無秩序』,混乱,乱雑(confusion) / 《しばしば複数形で》(社会的・政治的な)粉争,騒動 / 〈C〉(肉体的・精神的な)不調,異常,障害 / …‘の'秩序を乱す / 〈心身〉‘に'異常を起こさせる
コラージュ / 〈C〉画面に絵具以外のいろいろな素材を貼り付けて耕成した絵 / 〈U〉1の絵画技法

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/01 19:40:26」(JST)

wiki en

A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs. These tissues form a framework, or matrix, for the body, and are composed of two major structural protein molecules: collagen and elastin. There are many different types of collagen protein in each of the body's tissues. Elastin has the capability of stretching and returning to its original length—like a spring or rubber band. Elastin is the major component of ligaments (tissues that attach bone to bone) and skin. In patients with connective tissue disease, it is common for collagen and elastin to become injured by inflammation. Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune system that is directed against one's own body tissues (autoimmunity).^[1]

Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. Collagen vascular diseases can be (but are not necessarily) associated with collagen and blood vessel abnormalities and that are autoimmune in nature.^[1] See also vasculitis.

Connective tissue diseases can have strong or weak inheritance risks, and can also be caused by environmental factors.

Heritable connective tissue disorders

Marfan syndrome – a genetic disease causing abnormal fibrillin.
Ehlers-Danlos syndrome – defect in the synthesis of collagen (Type I or III) causes progressive deterioration of collagens, with different EDS types affecting different sites in the body, such as joints, heart valves, organ walls, arterial walls
Osteogenesis imperfecta (brittle bone disease) – caused by insufficient production of normal collagen (primarily type I) to produce healthy, strong bones.
Stickler syndrome – affects collagen (primarily type II and XI), and may result in a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems.

Autoimmune connective tissue disorders

Main article: Autoimmunity

These are also referred to as systemic autoimmune diseases. The autoimmune CTDs may have both genetic and environmental causes. Genetic factors may create a predisposition towards developing these autoimmune diseases. They are characterized as a group by the presence of spontaneous overactivity of the immune system that results in the production of extra antibodies into the circulation. The classic collagen vascular diseases have a "classic" presentation with typical findings that doctors can recognize during an examination. Each also has "classic" blood test abnormalities and abnormal antibody patterns. However, each of these diseases can evolve slowly or rapidly from very subtle abnormalities before demonstrating the classic features that help in the diagnosis. The classic collagen vascular diseases include:

Systemic lupus erythematosus (SLE) – An inflammation of the connective tissues, SLE can afflict every organ system. It is up to nine times more common in women than men and strikes black women three times as often as white women. The condition is aggravated by sunlight.
Rheumatoid arthritis – Rheumatoid arthritis is a systemic disorder in which immune cells attack and inflame the membrane around joints. It also can affect the heart, lungs, and eyes. Of the estimated 2.1 million Americans with rheumatoid arthritis, approximately 1.5 million (71 percent) are women.
Scleroderma – an activation of immune cells that produces scar tissue in the skin, internal organs, and small blood vessels. It affects women three times more often than men overall, but increases to a rate 15 times greater for women during childbearing years, and appears to be more common among black women.
Sjögren's syndrome – also called Sjögren's disease, is a chronic, slowly progressing inability to secrete saliva and tears. It can occur alone or with rheumatoid arthritis, scleroderma, or systemic lupus erythematosus. Nine out of 10 cases occur in women, most often at or around mid-life.
Mixed connective tissue disease – Mixed connective-tissue disease (MCTD) is a disorder in which features of various connective-tissue diseases (CTDs) such as systemic lupus erythematosus (SLE); systemic sclerosis (SSc); dermatomyositis (DM); polymyositis (PM); and, occasionally, Sjögren syndrome can coexist and overlap. The course of the disease is chronic and usually milder than other CTDs. In most cases, MCTD is considered an intermediate stage of a disease that eventually becomes either SLE or Scleroderma.

Other connective tissue disorders

Scurvy – caused by a dietary deficiency in vitamin C, leading to abnormal collagen.

References

^ ^a ^b William C. Shiel Jr.,Connective Tissue Disease

External links

Merck Manual: Musculoskeletal and connective tissue disorders
Merck Manual: Inherited connective tissue disorders
Arthritis Foundation
The Myositis Foundation

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. マルファン症候群および関連疾患の遺伝学、臨床的特徴、および診断 genetics clinical features and diagnosis of marfan syndrome and related disorders
2. 過剰可動性症候群の臨床症状および治療 clinical manifestations and treatment of the hypermobility syndrome
3. POEMS症候群 poems syndrome
4. 後天性表皮水疱症 epidermolysis bullosa acquisita
5. 壊疽性膿皮症：病因、臨床症状、および診断 pyoderma gangrenosum pathogenesis clinical features and diagnosis

English Journal

Both spontaneous Ins2(+/-) and streptozotocin-induced type I diabetes cause bone loss in young mice.

Coe LM, Zhang J, McCabe LR.SourceDepartments of Physiology and Radiology, Biomedical Imaging Research Center, Michigan State University, East Lansing, Michigan.
Journal of cellular physiology.J Cell Physiol.2013 Apr;228(4):689-95. doi: 10.1002/jcp.24177.
The adolescent skeleton undergoes accelerated growth determining overall bone density, length, and quality. Diseases such as type 1 diabetes (T1D), most often diagnosed in adolescents, can alter bone processes and promote bone loss. Studies examining type 1 diabetic (T1D) bone pathologies typically
PMID 22886636

A series of patients on anti-TNF therapy referred to a multidisciplinary lung cancer service.

O'Connell C, Hensey M, Mongey AB, Veale DJ, Donnelly SC.SourceDepartment of Respiratory Medicine, Education & Research Centre, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Irish journal of medical science.Ir J Med Sci.2013 Mar;182(1):135-7. doi: 10.1007/s11845-012-0821-x. Epub 2012 Apr 11.
BACKGROUND: Biological therapies have significantly improved the quality of life of patients with aggressive collagen vascular diseases. Blocking TNF activity may potentially confer a higher malignant potential for patients.AIMS: To identify patients to whom anti-TNF therapies were recently prescrib
PMID 22492023

Characterization of lipid and lipoprotein metabolism in primary human hepatocytes.

Ling J, Lewis J, Douglas D, Kneteman NM, Vance DE.SourceGroup on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2S2. Electronic address: jil@ualberta.ca.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Feb;1831(2):387-97. doi: 10.1016/j.bbalip.2012.08.012. Epub 2012 Aug 23.
Primary rodent hepatocytes and hepatoma cell lines are commonly used as model systems to elucidate and study potential drug targets for metabolic diseases such as obesity and atherosclerosis. However, if therapies are to be developed, it is essential that our knowledge gained from these systems is t
PMID 22951416

Japanese Journal

皮膚から見た膠原病

長谷川稔
アレルギー 64(1), 32-37, 2015-02-01
NAID 110009908911

皮膚から見た膠原病

長谷川稔
アレルギー 64(1), 32-37, 2015-02
NAID 40020350772

ONO-1301, a Sustained-Release Prostacyclin Analog, Ameliorates the Renal Alterations in a Mouse Type 2 Diabetes Model Possibly Through Its Protective Effects on Mesangial Cells

Watatani Hiroyuki,Yamasaki Hiroko,Maeshima Yohei,Nasu Tatsuyo,Hinamoto Norikazu,Ujike Haruyo,Sugiyama Hitoshi,Sakai Yoshiki,Tanabe Katsuyuki,Makino Hirofumi
Acta Medica Okayama 69(1), 1-15, 2015-02
… Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. …
NAID 120005549937