構造転位、構造遷移

WordNet

make or undergo a transition (from one state or system to another); "The airline transitioned to more fuel-efficient jets"; "The adagio transitioned into an allegro"
a musical passage moving from one key to another (同)modulation
a change from one place or state or subject or stage to another
a passage that connects a topic to one that follows
cause to convert or undergo a transition; "the company had to transition the old practices to modern technology"
a symmetrical arrangement of the parts of a thing

PrepTutorEJDIC

(…から…へ)移り変わること,変遷;(…から…への)過渡期《+from+名+to+名》
〈C〉形態,構造;調和のとれた配置(配列) / 〈U〉(型・性格などべの)一至,適合,適応《+『to』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/06/20 17:18:26」(JST)

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In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

A macromolecule is usually flexible and dynamic. It can change its shape in response to changes in its environment or other factors; each possible shape is called a conformation, and a transition between them is called a conformational change. Factors that may induce such changes include:

temperature,
pH,
voltage,
ion concentration,
phosphorylation, or
the binding of a ligand.

Laboratory analysis

Many biophysical techniques such as crystallography, NMR, electron paramagnetic resonance (EPR) using spin label techniques, circular dichroism (CD), hydrogen exchange, and FRET can be used to study macromolecular conformational change. Dual polarisation interferometry is a benchtop technique capable of measuring conformational changes in biomolecules in real time at very high resolution.

A specific nonlinear optical technique called second-harmonic generation (SHG) has been recently applied to the study of conformational change in proteins. In this method, a second-harmonic-active probe is placed at a site that undergoes motion in the protein by mutagenesis or non-site-specific attachment, and the protein is adsorbed or specifically immobilized to a surface. A change in protein conformation produces a change in the net orientation of the dye relative to the surface plane and therefore the intensity of the second harmonic beam. In a protein sample with a well-defined orientation, the tilt angle of the probe can be quantitatively determined, in real space and real time. Second-harmonic-active unnatural amino acids can also be used as probes.

Another method applies electro-switchable biosurfaces where proteins are placed on top of short DNA molecules which are then dragged through a buffer solution by application of alternating electrical potentials. By measuring their speed which ultimately depends on their hydrodynamic friction, conformational changes can be visualized.

External links

Book Chapter on Protein Motions from website of RH Austin [1] at Princeton University
Frauenfelder, H. New looks at protein motions Nature 338, 623 - 624 (20 April 1989).
Sensing with electro-switchable biosurfaces
Biodesy

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English Journal

Regioselective sulfation of Artemisia sphaerocephala polysaccharide: Solution conformation and antioxidant activities in vitro.

Wang J1, Yang W2, Tang Y2, Xu Q2, Huang S2, Yao J2, Zhang J3, Lei Z4.
Carbohydrate polymers.Carbohydr Polym.2016 Jan 20;136:527-36. doi: 10.1016/j.carbpol.2015.09.073. Epub 2015 Sep 28.
Regioselective modification is an effective approach to synthesize polysaccharides with different structure features and improved properties. In this study, regioselective sulfation of Artemisia sphaerocephala polysaccharide (SRSASP) was prepared by using triphenylchloromethane (TrCl) as protecting
PMID 26572384

Tautomeric conversion, vibrational spectra, and density functional studies on peripheral sulfur derivatives of benzothiazole and benzothiazoline isomers.

Altun A1, Kuliyev E2, Aghatabay NM2.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2016 Jan 5;152:181-91. doi: 10.1016/j.saa.2015.07.071. Epub 2015 Jul 15.
The room temperature structural (tautomerism, dimerization, conformational preference, geometry parameters) and vibrational spectral (IR and Raman) analyses have been performed on benzothiazoline (benzothiazoline-2-thione, 3-methyl-benzothiazoline-2-thione) and benzothiazole [2-mercaptobenzothiazole
PMID 26210013

Probing the gel to liquid-crystalline phase transition and relevant conformation changes in liposomes by (13)C magic-angle spinning NMR spectroscopy.

Purusottam RN1, Sénicourt L2, Lacapère JJ2, Tekely P3.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Dec;1848(12):3134-9. doi: 10.1016/j.bbamem.2015.09.011. Epub 2015 Sep 12.
PMID 26375416