- set into opposition or rivalry; "let them match their best athletes against ours"; "pit a chess player against the Russian champion"; "He plays his two children off against each other" (同)oppose, match, play off
- a concavity in a surface (especially an anatomical depression) (同)fossa
- remove the pits from; "pit plums and cherries" (同)stone
- a trap in the form of a concealed hole (同)pitfall
- a surface excavation for extracting stone or slate; "a British term for `quarry is `stone pit" (同)quarry, stone pit
- (auto racing) an area at the side of a racetrack where the race cars are serviced and refueled
- (commodity exchange) the part of the floor of a commodity exchange where trading in a particular commodity is carried on
- an enclosure in which animals are made to fight
- a sizeable hole (usually in the ground); "they dug a pit to bury the body" (同)cavity
- put a coat on; cover the surface of; furnish with a surface; "coat the cake with chocolate" (同)surface
- cover or provide with a coat
- growth of hair or wool or fur covering the body of an animal (同)pelage
- an outer garment that has sleeves and covers the body from shoulder down; worn outdoors
- form a coat over; "Dirt had coated her face" (同)cake
- the ratio of the circumference to the diameter of a circle; approximately equal to 3.14159265358979323846...
- the 16th letter of the Greek alphabet
- having or dressed in a coat
- having a coating; covered with an outer layer or film; often used in combination; "coated paper has a smooth polished coating especially suitable for halftone printing"; "sugar-coated pills"
- (自然の,または掘った)『地面の穴』,『くぼみ』 / 《しばしば単数形で》《the pit》立て坑,採掘場 / 落とし穴 / 《単数形で》《the pit》《英》(劇場の)平土間(1階正面後部の安い料金の席全体を指す);平土間の観客;《米》(舞台手前の1段低くなった)オーケストラ席 / (身体や物の表面の自然にできた)くぼみ / 《しばしば複数形で》(傷・天然痘などでできた皮膚の)小さなくぼんだ跡,あばた / (動物を入れておく)囲い;闘鶏場(cockpit),闘犬場 / 《the ~》地獄(hell) / ピット / 自動車修理店などで,車体の下で作業するために床に設けたくぼみ / 《the pits》自動車レースで給油・タイヤ交換などの場所 / …‘に'点々と穴をあける;…‘を'あばたにする / (…と)…‘を'取り組ませる,対坑させる《+『名』+『against』+『名』》
- (サクランボ・モモなどの)核,種(stone) / 〈果物〉‘から'種を取り除く
- 『コート』,オーバー,外とう / (男子背広・婦人スーツの)『上着』;(婦人・子供の)長上着 / (動物の)毛,毛皮;(植物の)外被,皮 / 表面をおおうもの;(ペンキ・ニスなどの)塗り;(金属などの)めっき / 〈人〉‘に'上旦を旦せる / 〈ほこりなどが〉〈症など〉'を'『おおう』;(ペンキなどで)〈壁など〉'を'塗る《+『名』+『with』+『名』》
- 〈C〉パイ(ギリシア語アルファベットの第16字Π,π;英語のP,pに相当) / 〈U〉円周率(記号はπ)
- ごちゃまぜの活字 / ごちゃまぜ,混乱
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- Quantifying the dynamic interactions between a clathrin-coated pit and cargo molecules.
- Weigel AV, Tamkun MM, Krapf D.Author information School of Biomedical Engineering and Departments of Biomedical Sciences, Biochemistry and Molecular Biology, and Electrical and Computer Engineering, Colorado State University, Fort Collins, CO 80523.AbstractClathrin-mediated endocytosis takes place through the recruitment of cargo molecules into a growing clathrin-coated pit (CCP). Despite the importance of this process to all mammalian cells, little is yet known about the interaction dynamics between cargo and CCPs. These interactions are difficult to study because CCPs display a large degree of lifetime heterogeneity and the interactions with cargo molecules are time dependent. We use single-molecule total internal reflection fluorescence microscopy, in combination with automatic detection and tracking algorithms, to directly visualize the recruitment of individual voltage-gated potassium channels into forming CCPs in living cells. We observe association and dissociation of individual channels with a CCP and, occasionally, their internalization. Contrary to widespread ideas, cargo often escapes from a pit before abortive CCP termination or endocytic vesicle production. Thus, the binding times of cargo molecules associating to CCPs are much shorter than the overall endocytic process. By measuring tens of thousands of capturing events, we build the distribution of capture times and the times that cargo remains confined to a CCP. An analytical stochastic model is developed and compared with the measured distributions. Due to the dynamic nature of the pit, the model is non-Markovian and it displays long-tail power law statistics. The measured distributions and model predictions are in excellent agreement over more than five orders of magnitude. Our findings identify one source of the large heterogeneities in CCP dynamics and provide a mechanism for the anomalous diffusion of proteins in the plasma membrane.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Nov 26;110(48):E4591-600. doi: 10.1073/pnas.1315202110. Epub 2013 Nov 11.
- Clathrin-mediated endocytosis takes place through the recruitment of cargo molecules into a growing clathrin-coated pit (CCP). Despite the importance of this process to all mammalian cells, little is yet known about the interaction dynamics between cargo and CCPs. These interactions are difficult to
- PMID 24218552
- Role of FK506 binding protein 5 (FKBP5) in osteoclast differentiation.
- Kimura M, Nagai T, Matsushita R, Hashimoto A, Miyashita T, Hirohata S.Author information Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa, 228-8555, Japan.AbstractOBJECTIVES: We previously disclosed the enhanced expression of FK506 binding protein 5 (FKBP5) messenger RNA (mRNA) in bone marrow (BM) CD34(+) cells in rheumatoid arthritis (RA), in which systemic osteoporosis takes place. Since BM CD34(+) cells are precursors of osteoclasts, it is possible that FKBP5 overexpression might lead to osteoporosis by affecting osteoclastogenesis. We therefore explore the influences of FKBP5 in osteoclast differentiation.
- Modern rheumatology / the Japan Rheumatism Association.Mod Rheumatol.2013 Nov;23(6):1133-9. doi: 10.1007/s10165-012-0809-4. Epub 2012 Dec 21.
- OBJECTIVES: We previously disclosed the enhanced expression of FK506 binding protein 5 (FKBP5) messenger RNA (mRNA) in bone marrow (BM) CD34(+) cells in rheumatoid arthritis (RA), in which systemic osteoporosis takes place. Since BM CD34(+) cells are precursors of osteoclasts, it is possible that F
- PMID 23263277
- αTAT1 catalyses microtubule acetylation at clathrin-coated pits.
- Montagnac G, Meas-Yedid V, Irondelle M, Castro-Castro A, Franco M, Shida T, Nachury MV, Benmerah A, Olivo-Marin JC, Chavrier P.Author information 1] Institut Curie, Research Center, 75005 Paris, France  Membrane and Cytoskeleton Dynamics, CNRS UMR 144, 75005 Paris, France.AbstractIn most eukaryotic cells microtubules undergo post-translational modifications such as acetylation of α-tubulin on lysine 40, a widespread modification restricted to a subset of microtubules that turns over slowly. This subset of stable microtubules accumulates in cell protrusions and regulates cell polarization, migration and invasion. However, mechanisms restricting acetylation to these microtubules are unknown. Here we report that clathrin-coated pits (CCPs) control microtubule acetylation through a direct interaction of the α-tubulin acetyltransferase αTAT1 (refs 8, 9) with the clathrin adaptor AP2. We observe that about one-third of growing microtubule ends contact and pause at CCPs and that loss of CCPs decreases lysine 40 acetylation levels. We show that αTAT1 localizes to CCPs through a direct interaction with AP2 that is required for microtubule acetylation. In migrating cells, the polarized orientation of acetylated microtubules correlates with CCP accumulation at the leading edge, and interaction of αTAT1 with AP2 is required for directional migration. We conclude that microtubules contacting CCPs become acetylated by αTAT1. In migrating cells, this mechanism ensures the acetylation of microtubules oriented towards the leading edge, thus promoting directional cell locomotion and chemotaxis.
- Nature.Nature.2013 Oct 24;502(7472):567-70. doi: 10.1038/nature12571. Epub 2013 Oct 6.
- In most eukaryotic cells microtubules undergo post-translational modifications such as acetylation of α-tubulin on lysine 40, a widespread modification restricted to a subset of microtubules that turns over slowly. This subset of stable microtubules accumulates in cell protrusions and regulates cel
- PMID 24097348
- ショットピーニングおよびアノダイズによる高強度アルミニウム合金7050 の疲労特性への影響
- 井上 明子,田川 哲哉,石川 孝司
- 表面技術 65(4), 179-187, 2014
- … Two levels of shot peening intensity, 0.08mmA (SP 8A) and 0.15mmA (SP 15A) were respectively applied to the specimen surface, and then, they were coated with a chromic acid anodizing (CAA), the thickness of which was between 1 and 3 μm. … The fatigue crack in SP 8A + CAA were initiated from the bottom of anodized pit. …
- NAID 130005061405
- coated pit noun Cell Biology. a clathrin-lined depression in the outer surface of a cell membrane, formed of receptors and their specific ligands, that becomes a coated vesicle upon endocytosis. Dictionary.com Unabridged Based on ...
- Coated Pit A specialized depression on the cytoplasmic face of the cell membrane, lined by a ‘scaffolding’ protein, clathrin. Coated pits are the 1st stage in forming a coated vesicle, which internalises and degrades receptors for VIP ...
- coated pit