切断・・リアデニル化特異的因子、切断・・リアデニル化特異性因子
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- (embryology) the repeated division of a fertilised ovum (同)segmentation
- the breaking of a chemical bond in a molecule resulting in smaller molecules
- the state of being split or cleft; "there was a cleavage between the liberal and conservative members"
- the act of cleaving or splitting
- the line formed by a groove between two parts (especially the separation between a womans breasts)
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the quality of being specific rather than general; "add a desirable note of specificity to the discussion"; "the specificity of the symptoms of the disease"
- the quality of being specific to a particular organism; "host specificity of a parasite"
PrepTutorEJDIC
- 《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 割る(割れる)こと;割れ(裂け)目 / 卵割(受精卵の細胞分裂) / (鉱物の結晶の)劈開(へきかい) / 《話》(大きなえりぐりのドレスから見える)乳房の谷間
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- 特性を持っていること;特質,特性
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/13 19:46:13」(JST)
[Wiki en表示]
Cleavage and polyadenylation specificity factor (CPSF) (or Cleavage polyadenylation stimulating factor) is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (pre-mRNA) molecule in the process of gene transcription. It is the first protein to bind to the signaling region near the cleavage site of the pre-mRNA, to which the polyadenine tail will be added by polyadenine polymerase. The upstream signaling region has the canonical nucleotide sequence AAUAAA, which is highly conserved across the vast majority of pre-mRNAs. A second downstream signaling region, located on the portion of the pre-mRNA that is cleaved before polyadenylation, consists of a GU-rich region required for efficient processing.
CPSF is a protein complex consisting of four proteins: CPSF-73, CPSF-100, CPSF-30 and CPSF-160. CPSF-73 is believed to be the endonuclease which cleaves mRNA precursor and the crystal structure of its N-terminal domain has been resolved. CPSF recruits additional proteins to the 3' region. Identified proteins that are coordinated by CPSF activity include: cleavage stimulatory factor and the two poorly understood cleavage factors. The binding of the polyadenine polymerase responsible for actually synthesizing the tail is a necessary prerequisite for cleavage, thus ensuring that cleavage and polyadenylation are tightly coupled processes.
Genes[edit]
- CPSF1, CPSF2, CPSF3, CPSF4, CPSF6
References[edit]
- Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004). Molecular Cell Biology. WH Freeman: New York, NY. 5th ed.
- Murthy KG, Manley JL. (1995). The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. Gene Dev 9: 2672-2683.
External links[edit]
- Cleavage And Polyadenylation Specificity Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
Carrier proteins, Nucleoprotein: RNA-binding protein
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- Butyrate response factor 1
- Fragile X mental retardation protein
- Rev
- hu paraneoplastic encephalomyelitis antigens
- mRNA cleavage and polyadenylation factors (Cleavage and polyadenylation specificity factor
- Cleavage stimulation factor)
- host factor 1 protein
- Aconitase (ACO1
- ACO2)
- nuclear factor 90 proteins (ILF2)
- Poly(A)-binding protein (PABPC1
- PABPC3
- PABPC4)
- polypyrimidine tract-binding protein
- ribonucleoprotein
- RNA cap-binding protein (Cap binding complex
- EIF4E
- EIF4G1)
- SMN complex proteins (SMN1
- SMN2
- DDX20)
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B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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Post-transcriptional modification
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Nuclear |
- Precursor mRNA
- 5′ cap formation
- Polyadenylation
- CPSF
- CstF
- PAP
- PAB2
- CFI
- CFII
- Poly(A)-binding protein
- RNA splicing: intron/exon
- snRNP
- spliceosome
- alternative splicing
- pre-mRNA processing factor
- PLRG1
- PRPF3
- PRPF4
- PRPF4B
- PRPF6
- PRPF8
- PRPF18
- PRPF19
- PRPF31
- PRPF38A
- PRPF38B
- PRPF39
- PRPF40A
- PRPF40B
- RNA editing
- Polyuridylation
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Cytosolic |
5′ cap methylation
- Messenger RNA decapping: DCP1A
- DCP1B
- DCP2
- DCPS
- EDC3
- EDC4
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see also: disorders of transcription and post transcriptional modification, Transcription
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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UpToDate Contents
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Japanese Journal
- Case study on the evolution of hetero-oligomer interfaces based on the differences in paralogous proteins
- The 73kD subunit of the cleavage and polyadenylation specificity factor (CPSF) complex affects reproductive development in Arabidopsis
- 抗腫瘍ワクチンとしてのCPSF(Cleavage and polyadenylation specificity factor)由来HLA-A2拘束性ペプチド
Related Links
- Cleavage and polyadenylation specificity factor (CPSF) (or Cleavage polyadenylation stimulating factor) is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (pre-mRNA) molecule in the ...
- I am working on Schizosaccharomyces pombe as model system organism.We have some mutants of m-RNA processing machinery genes.We want to check that these genes are defective in cleavage or polyadenylation or not .So ...
Related Pictures
★リンクテーブル★
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- 英
- cleavage and polyadenylation specificity factor
- 関
- 切断・・リアデニル化特異的因子
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- 英
- cleavage and polyadenylation specificity factor
- 関
- 切断・ポリアデニル化特異性因子
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- 同
- cleavage and polyadenylation specificity factor
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- 裂けること、裂開、分割。(政党などの)分裂(between)
- (襟ぐりの深いドレスであらわになった)女性の乳房の間のくぼみ、乳房の谷間
- 劈開
- 劈開面
- (受精卵の)卵割
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- 関
- actual、actually、in fact、in practice、indeed、practically
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- 関
- element、elementary、factorial、parameter
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- 関
- sensitivity、speciality、specific