clear cell sarcoma

明細胞肉腫、淡明細胞肉腫、軟部悪性黒色腫

WordNet

1. sell; "We cleared a lot of the old model cars"
2. free (the throat) by making a rasping sound; "Clear the throat" (同)clear_up
3. make a way or path by removing objects; "Clear a path through the dense forest"
4. remove; "clear the leaves from the lawn"; "Clear snow from the road"
5. the state of being free of suspicion; "investigation showed that he was in the clear"
6. completely; "read the book clear to the end"; "slept clear through the night"; "there were open fields clear to the horizon" (同)all_the_way
7. clear and distinct to the senses; easily perceptible; "as clear as a whistle"; "clear footprints in the snow"; "the letter brought back a clear image of his grandfather"; "a spire clean-cut against the sky"; "a clear-cut pattern" (同)clean-cut, clear-cut
8. make free from confusion or ambiguity; make clear; "Could you clarify these remarks?"; "Clear up the question of who is at fault" (同)clear_up, shed_light_on, crystallize, crystallise, crystalize, crystalise, straighten out, sort out, enlighten, illuminate, elucidate
9. easily deciphered (同)decipherable, readable
10. affording free passage or view; "a clear view"; "a clear path to victory"; "open waters"; "the open countryside" (同)open
11. characterized by ease and quickness in perceiving; "clear mind"; "a percipient author" (同)percipient
12. settle, as of a debt; "clear a debt"; "solve an old debt" (同)solve
13. pass by, over, or under without making contact; "the balloon cleared the tree tops" (同)top
14. (especially of a title) free from any encumbrance or limitation that presents a question of fact or law; "I have clear title to this property" (同)unmortgaged
15. allowing light to pass through; "clear water"; "clear plastic bags"; "clear glass"; "the air is clear and clean"
16. be debited and credited to the proper bank accounts; "The check will clear within 2 business days"
17. characterized by freedom from troubling thoughts (especially guilt); "a clear conscience"; "regarded her questioner with clear untroubled eyes"
18. clear from impurities, blemishes, pollution, etc.; "clear the water before it can be drunk"
19. clear of charges or deductions; "a clear profit"
20. free from clouds or mist or haze; "on a clear day"
21. free from confusion or doubt; "a complex problem requiring a clear head"; "not clear about what is expected of us"
22. free from contact or proximity or connection; "we were clear of the danger"; "the ship was clear of the reef"
23. free from flaw or blemish or impurity; "a clear perfect diamond"; "the clear complexion of a healthy young woman"
24. free from payment of customs duties, as of a shipment; "Clear the ship and let it dock"
25. go away or disappear; "The fog cleared in the afternoon"
26. make clear, bright, light, or translucent; "The water had to be cleared through filtering"
27. pass an inspection or receive authorization; "clear customs"
28. readily apparent to the mind; "a clear and present danger"; "a clear explanation"; "a clear case of murder"; "a clear indication that she was angry"; "gave us a clear idea of human nature"
29. remove (people) from a building; "clear the patrons from the theater after the bomb threat"
30. remove the occupants of; "Clear the building"
31. rid of instructions or data; "clear a memory buffer"
32. small room in which a monk or nun lives (同)cubicle
33. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
34. a room where a prisoner is kept (同)jail cell, prison cell
35. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
36. any small compartment; "the cells of a honeycomb"
37. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
38. the act of removing solid particles from a liquid (同)clarification
39. the act of freeing from suspicion
40. a tract of land with few or no trees in the middle of a wooded area (同)glade
41. a usually malignant tumor arising from connective tissue (bone or muscle etc.); one of the four major types of cancer
42. rid of objects or obstructions such as e.g. trees and brush; "cleared land"; "cleared streets free of fallen trees and debris"; "a cleared passage through the underbrush"; "played poker on the cleared dining room table"

PrepTutorEJDIC

1. 『晴れた』;明るい(bright) / 『透き通った』,透明な / (形・輪郭などが)『はっきりした』,くっきりした / (音が)はっきり聞こえる(聞き取れる) / 『分かりやすい』,あいまいさのない / 《補語にのみ用いて》はっきり知っている,確信している / 明せきな,理路整然とした / 妨害(支障)のない / 汚れ(しみ,きず)がない / 《補語のみ用いて》(…を)免れた,(…が)ない,(…から)解放された《+『of』+『名』》 / 《名詞の前,時に名詞の後に用いて》丸々の;正味の / はっきりと,明瞭に,明確に / (…から)離れて《+『of』+『名』》 / 全く,まるまる / (…を)…‘から'『取り除く』,片付ける;(人を)…‘から'立ち去らせる《+『名』+『of』+『名』》 / (…から)〈物〉'を'『取り除く』,片付ける;(…から)〈人〉'を'立ち去らせる《『名』『+『from』(『out of』,『off』)+『名』》 / 'を'きれいにする,清らかにする;…を明るくする / …‘に'触れないで越す / (罪・疑い・責任などから)…'を'逃れさせる』,免除する《+『名』+『of』+『名』》 / 〈議会・税関・手形交換所など〉'を'すんなりと通過する,‘の'許可を簡単に得る / 《話》…'を'まるまるもうける,‘の'純益を上げる / 〈負債〉を清算する,〈手形〉を釧済する;〈小切手〉を現金化する / 『明るくなる』;澄む / 消え去る,過ぎ去る / (じゃま物のない)開けた場所,あき地
2. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
3. (森の一部を伐採して作った)開墾地,小さなあき地
4. 肉腫(にくしゅ)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/28 20:20:39」(JST)

wiki en

[Wiki en表示]

Clear-cell sarcoma
Classification and external resources
Clear cell sarcoma. Tumor cells with prominent nucleoli and clear cytoplasm are arranged in well-defined nests surrounded by dense fibrous stroma.
ICD-O:	9044/3
MeSH	D018227

Clear-cell sarcoma (formerly known as malignant melanoma of the soft parts) is a rare form of cancer called sarcoma. It is known to occur mainly in the soft tissues and dermis. Rare forms were thought to occur in the gastrointestinal tract before they were discovered to be different and redesignated as GNET.

Recurrence is common.

It has been associated with both EWSR1-ATF1 and EWSR1-CREB1 fusion transcripts.

Clear cell sarcoma of the soft tissues in adults is not related to the pediatric tumor known as clear cell sarcoma of the kidney.

Pathology

Under a microscope these tumors show some similarities to traditional skin melanomas, and are characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. The clear cell sarcoma has a uniform and distinctive morphological pattern which serves to distinguish it from other types of sarcoma.

Diagnosis

Imaging studies such as X-rays, computed tomography scans, or MRI may be required to diagnose clear-cell sarcoma together with a physical exam. Normally a biopsy is also necessary. Furthermore, a chest CT, a bone scan and positron emission tomography (PET) may be part of the tests in order to evaluate areas where metastasizes occurs.

Signs and symptoms

It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated. Patients often perceive it as a lump or hard mass. It causes either pain or tenderness but only until it becomes large enough. This kind of tumor is commonly found in the extremities especially around the knee, feet and ankle. Patients diagnosed with clear cell sarcoma are usually between the ages of 20 and 40.

Prognosis

When the tumor is large and there is presence of necrosis and local recurrence, the prognosis is poor. Presence of metastasis occurs in more than 50% cases and the common places of its occurrence are the bone, lymph node and lungs. Five-year survival rates, which are reported to be between 50-65%, are inaccurate because the disease is prone to late metastasis or recurrence. Ten and twenty-year survival rates are 33% and 10%, respectively.

Treatment

Treatment depends upon the site and the extent of the disease. Clear cell sarcoma is usually treated with surgery in the first place in order to remove the tumor. The surgical procedure is then followed by radiation and sometimes chemotherapy. Few cases of clear cell sarcoma respond to chemotherapy. Several types of targeted therapy that may be of benefit to clear cell sarcoma patients are currently under investigation.

See also

• Melanoma
• Clear-cell sarcoma of the kidney
• List of cutaneous conditions
• Hyalinizing clear cell carcinoma - has the same chromosomal translocation

References

UpToDate Contents

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• 1. 軟部組織肉腫の臨床所見、病理組織学的検査、診断的評価、および病期分類 clinical presentation histopathology diagnostic evaluation and staging of soft tissue sarcoma
• 2. 転移性軟部組織肉腫の全身治療 systemic treatment of metastatic soft tissue sarcoma
• 3. ウィルムス腫瘍の症状、診断、および病期分類 presentation diagnosis and staging of wilms tumor
• 4. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
• 5. 黒色腫の病理学的特徴 pathologic characteristics of melanoma

English Journal

• KIT expression and methylation in medulloblastoma and PNET cell lines and tumors.

• Enguita-German M, Gurrea M, Schiapparelli P, Zhu TS, Crowley JG, Hamm LL, Costello MA, He X, Talsma CE, Flack CG, Hervey-Jumper SL, Heth JA, Muraszko KM, Rey JA, Fan X, Castresana JS.SourceBrain Tumor Biology Unit-CIFA, University of Navarra School of Sciences, Irunlarrea 1, 31008, Pamplona, Spain.
• Journal of neuro-oncology.2011 Jun;103(2):247-53. Epub 2010 Sep 19.
• The stem cell factor/kit tyrosine kinase receptor pathway is related to tumor growth and progression in several cancers including Ewing sarcoma, a peripheral PNET (pPNET). Identifying additional groups of tumors that may use the pathway is important as they might be responsive to imatinib mesylate t
• PMID 20853134

• Differential expression of cathepsin K in neoplasms harboring TFE3 gene fusions.

• Martignoni G, Gobbo S, Camparo P, Brunelli M, Munari E, Segala D, Pea M, Bonetti F, Illei PB, Netto GJ, Ladanyi M, Chilosi M, Argani P.SourceDepartment of Pathology and Diagnostic, University of Verona, Verona, Italy.
• Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.2011 May 20. [Epub ahead of print]
• Cathepsin K is a protease whose expression is driven by microphthalmia transcription factor (MITF) in osteoclasts. TFE3 and TFEB are members of the same transcription factor subfamily as MITF and all three have overlapping transcriptional targets. We have shown that all t(6;11) renal cell carcinomas
• PMID 21602817

Japanese Journal

• 足部に生じた明細胞肉腫の1例

• 米谷 あずみ,吉岡 伸高,新保 慶輔,中谷 浩子,平本 道昭
• Skin cancer : official organ of the Japanese Society for Skin Cancer = 皮膚悪性腫瘍研究会機関誌 25(1), 94-100, 2010-05-15
• NAID 10026549894

• 過去25年間に経験した小児腎腫瘍20例の管理および長期予後に関する検討

• 長 祐子,飯塚 進,畑江 芳郎,武田 武夫,内藤 春彦,山城 勝重,有賀 正
• 小児がん : 小児悪性腫瘍研究会記録 47(1), 73-78, 2010-02-25
• 1984年から2008年3月に北海道がんセンター小児科が閉鎖するまでの約25年間に当施設で新規診断,治療が行われた15歳未満の腎腫瘍20例を対象とし,その臨床像,治療法,治療合併症,晩期障害,転帰に関して検討を行った.手術,NWTSに準じた化学療法,放射線療法を行ない,17例が長期生存を得た.しかし診断後10年近く経過したのちに放射線治療や単腎に関連すると思われる様々な晩期障害が観察された.
• NAID 110007575320

Related Links

• Clear Cell Sarcoma

10 Mar 2008 ... The full name of this sarcoma is Clear Cell Sarcoma of Tendons and Aponeuroses. If that isn't enough, it is also known as malignant melanoma of soft parts. It gets its peculiar designation when pathologists noted that ...

Related Pictures

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★リンクテーブル★

リンク元	「淡明細胞肉腫」「明細胞肉腫」「軟部悪性黒色腫」
関連記事	「clear」「cell」

「淡明細胞肉腫」

　　[★]

英

clear cell sarcoma

関

明細胞肉腫、軟部悪性黒色腫

同

clear cell sarcoma

「明細胞肉腫」

　　[★]

英

clear cell sarcoma

関

淡明細胞肉腫、軟部悪性黒色腫

「軟部悪性黒色腫」

　　[★]

英

clear cell sarcoma

関

明細胞肉腫、淡明細胞肉腫

「clear」

　　[★]

• adj.

• 明るい、澄み切った。すんだ、透き通った。(音・声が)はっきり聞こえる

関

apparent、apparently、clarification、clearly、distinct、distinctly、evident、evidently、indisputable、obvious、obviously、overt、overtly、palpable、plain、pronounced、unambiguous、unambiguously、unequivocal

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「cell」

　　[★] 細胞