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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/04/13 20:09:40」(JST)

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English Journal

  • Examination of the optimal condition on the in vitro sensitivity to telomelysin in head and neck cancer cell lines.
  • Sakakibara A, Tsukuda M, Kondo N, Ishiguro Y, Kimura M, Fujita K, Takahashi H, Matsuda H.SourceDepartment of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
  • Auris, nasus, larynx.Auris Nasus Larynx.2011 Oct;38(5):589-99. Epub 2011 Feb 27.
  • PMID 21362583
  • RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt, ERK and NF-κB in colon carcinoma HCT116 cells.
  • Zhang H, Zhang S, He H, Zhao W, Ren K, Chen J, Shao RG.SourceInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 1# Tiantan Xili, Beijing 100050, China.
  • Cancer letters.Cancer Lett.2011 Sep 1;308(1):62-70. Epub 2011 May 13.
  • To increase the efficacy of currently used anti-cancer genotoxins, a combination use of different drugs is a potential new therapeutical tool. Here, we reported that a synthetic RasGAP-derived peptide 38GAP with RasGAP(301-326) and TAT penetration sequences could enhance the effect of chemotherapeut
  • PMID 21570766

Japanese Journal

  • Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway.
  • Yamamoto Kimiyo N,Kobayashi Shunsuke,Tsuda Masataka,Kurumizaka Hitoshi,Takata Minoru,Kono Koichi,Takeda Shunichi,Hirota Kouji
  • Proceedings of the National Academy of Sciences of the United States of America 108(16), 6492-6496, 2011-04-19
  • Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs processing involves the Fanconi anemia (FA) pathway and homologous recombin …
  • NAID 120003072120
  • 第59回日本泌尿器科学会中部総会シンポジウム「泌尿器科抗癌化学療法 : 最新レジメンの有効性と安全性」―司会の言葉―
  • 原 勲,元雄 良治
  • 泌尿器科紀要 57(3), 151-152, 2011-03-31
  • … (2) Urothelial cancer : gemcitabine and cisplatin (GC) therapy is taking over methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) therapy because of less toxicity. …
  • NAID 120003001362

Related Links

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) (trade names Platinol and Platinol-AQ) is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung ...

Related Pictures

リンク元シスプラチン」「M-VAC療法」「KAP STEP2CK2008 001」「GC regimen」「platinol



シスプラチナム cis-platinum, シスジアミンジクロロプラチナム cis-diamine-dichloroplatinum CDDP
  • first aid step1 2006 p.208,307,309


  • 抗悪性腫瘍薬
  • 白金錯化合物 platinum coordination complexes
  • 細胞周期非依存的に作用 (GOO.1320)
  • DNAと共有結合してDNA合成、細胞分裂を阻害
  • 静脈内投与のみ
  • 腎排泄
the aquated species of the drug then reacts with nucleophilic sites on DNA and proteins


  • 精巣癌、卵巣癌、頭頚部癌、膀胱癌、食道癌、肺癌、直腸癌
  • testicular, bladder, ovary, and lung carcinomas(first aid step1 2006 p.309)


  • 重篤な腎障害、骨髄抑制、聴力障害、消化器毒性
  • 視覚障害、脳梗塞、うっ血性心不全、悪心嘔吐
  • nephrotoxicity and acoustic nerve damage(first aid step1 2006 p.309)


  • 腎障害
  • 妊婦




M-VAC regimen

[show details]


KAP STEP2CK2008 001」


  • Internal medicine 1-10



  • asymmetry
  • border irregular
  • color variegation
  • diameter > 0.6cm

GC regimen」







  [★] シスプラチン CDDP