WordNet
- a substance that exerts some force or effect
- a businessman who buys or sells for another in exchange for a commission (同)factor, broker
- any agent or representative of a federal agency or bureau (同)federal agent
- a representative who acts on behalf of other persons or organizations
- an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
- remove the bones from; "bone the turkey before roasting it" (同)debone
- the porous calcified substance from which bones are made (同)osseous_tissue
- consisting of or made up of bone; "a bony substance"; "the bony framework of the body"
- a shade of white the color of bleached bones (同)ivory, pearl, off-white
- rigid connective tissue that makes up the skeleton of vertebrates (同)os
- of or related to the synthetic phase of metabolism
- characterized by or promoting constructive metabolism; "some athletes take anabolic steroids to increase muscle size temporarily"
- having bones as specified; "his lanky long-boned body"
- having had the bones removed; "a boneless rib roast"; "a boned (or deboned) fish" (同)deboned
- a percussion instrument consisting of a pair of hollow pieces of wood or bone (usually held between the thumb and fingers) that are made to click together (as by Spanish dancers) in rhythm with the dance (同)castanets, clappers, finger cymbals
PrepTutorEJDIC
- 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
- 〈C〉骨 / 〈U〉骨を作っている物質,骨質 / 《複数形で》骨格;死骸(がい) / 〈魚など〉‘の'骨を取る
- (魚など)骨を取り除いた / (衣服が)(コルセットなどで)骨で張りをつけた[ような]
UpToDate Contents
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English Journal
- A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates.
- Murphy CM1, Schindeler A2, Gleeson JP3, Yu NY2, Cantrill LC2, Mikulec K4, Peacock L4, O'Brien FJ5, Little DG2.Author information 1Orthopaedic Research & Biotechnology Unit, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia. Electronic address: ciara.murphy@sydney.edu.au.2Orthopaedic Research & Biotechnology Unit, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia.3Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland.4Orthopaedic Research & Biotechnology Unit, The Children's Hospital at Westmead, Sydney, NSW, Australia.5Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, Dublin, Ireland; Trinity Centre for Bioengineering, Trinity College, Dublin, Ireland; Advanced Materials and BioEngineering Research Centre (AMBER), RCSI & TCD, Dublin, Ireland.AbstractAn emerging paradigm in orthopedics is that a bone-healing outcome is the product of the anabolic (bone-forming) and catabolic (bone-resorbing) outcomes. Recently, surgical and tissue engineering strategies have emerged that combine recombinant human bone morphogenetic proteins (rhBMPs) and bisphosphonates (BPs) in order to maximize anabolism and minimize catabolism. Collagen-based scaffolds that are the current surgical standard can bind rhBMPs, but not BPs. We hypothesized that a biomimetic collagen-hydroxyapatite (CHA) scaffold would bind both agents and produce superior in vivo outcomes. Consistent with this concept, in vitro elution studies utilizing rhBMP-2 ELISA assays and scintillation counting of (14)C-radiolabeled zoledronic acid (ZA) confirmed delayed release of both agents from the CHA scaffold. Next, scaffolds were tested for their capacity to form ectopic bone after surgical implantation into the rat hind limb. Using CHA, a significant 6-fold increase in bone volume was seen in rhBMP-2/ZA groups compared to rhBMP-2 alone, confirming the ability of ZA to enhance rhBMP-2 bone formation. CHA scaffolds were found to be capable of generating mineralized tissue in the absence of rhBMP-2. This study has implications for future clinical treatments of critical bone defects. It demonstrates the relative advantages of co-delivering anabolic and anti-catabolic agents using a multicomponent scaffold system.
- Acta biomaterialia.Acta Biomater.2014 May;10(5):2250-8. doi: 10.1016/j.actbio.2014.01.016. Epub 2014 Jan 21.
- An emerging paradigm in orthopedics is that a bone-healing outcome is the product of the anabolic (bone-forming) and catabolic (bone-resorbing) outcomes. Recently, surgical and tissue engineering strategies have emerged that combine recombinant human bone morphogenetic proteins (rhBMPs) and bisphosp
- PMID 24456759
- Whole body vibration during fracture healing intensifies the effects of estradiol and raloxifene in estrogen-deficient rats.
- Stuermer EK1, Komrakova M2, Sehmisch S2, Tezval M2, Dullin C3, Schaefer N4, Hallecker J2, Stuermer KM2.Author information 1Institute for Research in Operative Medicine, Faculty of Health - School of Medicine, Witten/Herdecke University, Cologne, Germany; Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert-Koch 40, 37075 Goettingen Germany. Electronic address: ewa.stuermer@uni.wh.de.2Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert-Koch 40, 37075 Goettingen Germany.3Department of Radiology, University of Goettingen, Robert-Koch 40, 37075 Goettingen Germany.4Institute for Research in Operative Medicine, Faculty of Health - School of Medicine, Witten/Herdecke University, Cologne, Germany.AbstractCurrent osteoporosis therapies aim to delay bone destruction and have additional anabolic effects. While they have demonstrated some positive effects on bone healing, more progress is needed in this area. This study used the well-known osteoporotic agents estrogen (E) and raloxifene (R) in conjunction with biomechanical whole body vibration (WBV) at a frequency of 70Hz twice daily for six weeks to stimulate bone healing. Eighty-four 3-month old female Sprague-Dawley rats (12 per group) were bilaterally ovariectomized to develop osteopenia within eight weeks. Osteotomy of the metaphyseal tibiae was performed and fracture healing was then studied using mechanical tests, histomorphometry, computed tomography (μCT), and gene analysis. We found that E and R improved the structure of osteopenic bones as did WBV alone, although significant levels for WBV were seldom reached. Combination treatments significantly enhanced stiffness (R+WBV; p<0.05), endosteal bone (R+WBV; p<0.01), and trabecular density (E+WBV; p<0.05, R+WBV; p<0.05). In addition, the expression of osteoclast-specific Trap was significantly reduced after treatment with E, R, or their combination with WBV (p<0.01). The effects were additive and not inhibitory, leading us to conclude that the combined applications of WBV with E or R may improve the healing of osteopenic bones. The therapies studied are all currently approved for human use, suggesting ready applicability to clinical practice. To better understand the effects of WBV on osteopenic bones, the ideal vibration regime will require further study.
- Bone.Bone.2014 Apr 12. pii: S8756-3282(14)00143-4. doi: 10.1016/j.bone.2014.04.008. [Epub ahead of print]
- Current osteoporosis therapies aim to delay bone destruction and have additional anabolic effects. While they have demonstrated some positive effects on bone healing, more progress is needed in this area. This study used the well-known osteoporotic agents estrogen (E) and raloxifene (R) in conjuncti
- PMID 24735975
Japanese Journal
- Mechanism of the Tissue-Specific Action of the Selective Androgen Receptor Modulator S-101479
- Furuya Kazuyuki,Yamamoto Noriko,Ohyabu Yuki [他],Morikyu Teruyuki,Ishige Hirohide,Albers Michael,Endo Yasuhisa
- Biological and Pharmaceutical Bulletin 36(3), 442-451, 2013
- … Selective androgen receptor modulators (SARMs) comprise a new class of molecules that induce anabolic effects with fewer side effects than those of other anabolic agents. … We previously reported that the novel SARM S-101479 had a tissue-selective bone anabolic effect with diminished side effects in female animals. …
- NAID 130003382083
- The Novel Non-steroidal Selective Androgen Receptor Modulator S-101479 Has Additive Effects with Bisphosphonate, Selective Estrogen Receptor Modulator, and Parathyroid Hormone on the Bones of Osteoporotic Female Rats
- Furuya Kazuyuki,Yamamoto Noriko,Ohyabu Yuki [他],Makino Akito,Morikyu Teruyuki,Ishige Hirohide,Kuzutani Kazuya,Endo Yasuhisa
- Biological and Pharmaceutical Bulletin 35(7), 1096-1104, 2012
- … Many SARMs have been studied for their anabolic effects on bone or muscle with reduced virilizing effects in male animals. … However, the tissue selectivities of these agents in female animals have not been fully evaluated. … It increased the bone mineral density (BMD) of femurs and diminished the effects on the uterus and clitoral gland in OVX rats. …
- NAID 130001872113
Related Links
- The purposes of this review addressed under each selected drug subheading are to (1) review the bone physiologic effects of the most common anabolic agents either currently on the market or in development in vitro, (2 ...
- Bone Anabolic Agents David L. Kendler MD, FRCPC Bone remodeling is a coupled process in which old bone is resorbed and new bone is formed at the site of resorption. In the past, little has been understood about the molecular ...
★リンクテーブル★
[★]
- 代行者、代理人。代理業者
- 政府職員、官吏
- ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、~剤。病原体
- 関
- agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle
[★]
- 同化の、蛋白同化の、タンパク同化の、アナボリック、タンパク同化性の、蛋白同化性の
- 関
- anabolism、elaborate、elaboration、protein assimilation
[★]
骨