- 関
- ANF receptor、ANP receptor
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- of or relating to a cavity or chamber in the body (especially one of the upper chambers of the heart)
- of or relating to natriuresis
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/25 06:32:09」(JST)
[Wiki en表示]
An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.[1]
Contents
- 1 Mechanism
- 2 Types
- 3 References
- 4 External links
Mechanism
NPRA and NPRB are linked to guanylyl cyclases, while NPRC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand.
ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG), which will then induce smooth muscle relaxation. This is particularly important in the vasculature, where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of the vasculature to relax. This relaxation will decrease total peripheral resistance, which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart's having to do less work.
There is also a soluble guanylyl cyclase that cannot be stimulated by ANP. Instead, vascular endothelial cells will use L-arginine to make nitric oxide via nitric oxide synthase. The nitric oxide will then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase. The subsequent increase in cGMP will cause vasodilation with the same effects as described above. This is why nitroglycerine is given to a person having a heart attack. The nitroglycerine will be metabolized to nitric oxide, which will stimulate soluble guanylyl cyclase. This will result in a decrease in total peripheral resistance and a decrease in preload on the heart. As a result, work done by the heart will decrease and will allow the heart to contract less strongly. Weaker contractions will lead to more blood flow in the coronary arteries, which will help the ischemic cardiac myocytes.
Types
There are three distinct atrial natriuretic factor receptors identified so far in mammals: natriuretic peptide receptors 1, 2, and 3.
| natriuretic peptide receptor A/ guanylate cyclase A (atrionatriuretic peptide receptor A) |
| Identifiers |
| Symbol |
NPR1 |
| Alt. symbols |
ANPRA, NPRA |
| Entrez |
4881 |
| HUGO |
7943 |
| OMIM |
108960 |
| RefSeq |
NM_000906 |
| UniProt |
P16066 |
| Other data |
| Locus |
Chr. 1 q21-q22 |
|
| natriuretic peptide receptor B/ guanylate cyclase B (atrionatriuretic peptide receptor B) |
| Identifiers |
| Symbol |
NPR2 |
| Alt. symbols |
ANPRB, NPRB |
| Entrez |
4882 |
| HUGO |
7944 |
| OMIM |
108961 |
| RefSeq |
NM_003995 |
| UniProt |
P20594 |
| Other data |
| Locus |
Chr. 9 p21-p12 |
|
| natriuretic peptide receptor C/ guanylate cyclase C (atrionatriuretic peptide receptor C) |
| Identifiers |
| Symbol |
NPR3 |
| Alt. symbols |
ANPRC, NPRC |
| Entrez |
4883 |
| HUGO |
7945 |
| OMIM |
108962 |
| RefSeq |
NM_000908 |
| UniProt |
P17342 |
| Other data |
| Locus |
Chr. 5 p14-p1 |
|
References
- ^ Hirose S, Hagiwara H, Takei Y (August 2001). "Comparative molecular biology of natriuretic peptide receptors". Can. J. Physiol. Pharmacol. 79 (8): 665–72. doi:10.1139/cjpp-79-8-665. PMID 11558675.
External links
- Atrial Natriuretic Factor Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Neuropeptide receptors
|
|
| G protein-coupled receptor |
| Hormone receptors |
| Hypothalamic |
- CRH
- FSH
- LHRH
- TRH
- Somatostatin
|
|
| Pituitary |
- Vasopressin
- Oxytocin
- LHCG
- TSH
|
|
| Other |
- Atrial natriuretic factor
- Calcitonin
- Cholecystokinin
- VIP
|
|
|
| Opioid receptors |
- Delta
- Kappa
- Mu
- Nociceptin
|
|
| Other neuropeptide receptors |
- Angiotensin
- Bradykinin
- Tachykinin
- Calcitonin gene-related peptide
- Galanin
- GPCR neuropeptide
- Neurotensin
|
|
|
| Type I cytokine receptor |
|
|
| Enzyme-linked receptor |
- Atrial natriuretic factor
|
|
| Other |
|
UpToDate Contents
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English Journal
- Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats.
- de Raaf MA1, Herrmann FE2, Schalij I3, de Man FS4, Vonk-Noordegraaf A3, Guignabert C5, Wollin L2, Bogaard HJ6.
- American journal of physiology. Heart and circulatory physiology.Am J Physiol Heart Circ Physiol.2016 Sep 1;311(3):H604-12. doi: 10.1152/ajpheart.00656.2015. Epub 2016 Jun 24.
- BIBF1000 is a small molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), and platelet-derived growth factor receptor (PDGFR) and is a powerful inhibitor of fibrogenesis. BIBF1000 is very similar to BIBF1120 (ninte
- PMID 27342880
- GATA4 variant interaction with brain limbic structure and relapse risk: A voxel-based morphometry study.
- Zois E1, Vollstädt-Klein S2, Hoffmann S2, Reinhard I3, Bach P2, Charlet K4, Beck A4, Treutlein J5, Frank J5, Jorde A2, Kirsch M2, Degenhardt F6, Walter H4, Heinz A4, Kiefer F2.
- European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.Eur Neuropsychopharmacol.2016 Sep;26(9):1431-7. doi: 10.1016/j.euroneuro.2016.06.011. Epub 2016 Jul 7.
- Atrial natriuretic peptide (ANP) receptors are highly expressed in the amygdala, caudate and hypothalamus. GATA4 gene encodes a transcription factor of ANP associated with the pathophysiology of alcohol dependence. We have previously demonstrated that the GATA4 single nucleotide polymorphism (SNP) r
- PMID 27397865
- miR-155 functions downstream of angiotensin II receptor subtype 1 and calcineurin to regulate cardiac hypertrophy.
- Yang Y1, Zhou Y2, Cao Z1, Tong XZ1, Xie HQ1, Luo T1, Hua XP3, Wang HQ4.
- Experimental and therapeutic medicine.Exp Ther Med.2016 Sep;12(3):1556-1562. Epub 2016 Jul 5.
- Cardiac hypertrophy is characterized by maladaptive tissue remodeling that may lead to heart failure or sudden death. MicroRNAs (miRs) are negative regulators of angiotensin II and the angiotensin II receptor subtype 1 (AGTR1), which are two components involved in cardiac hypertrophy. In the present
- PMID 27588076
Japanese Journal
- Genetic factors associating the effects of habitual exercise on arterial stiffness
- The journal of physical fitness and sports medicine : JPFSM 2(3), 325-332, 2013-08-25
- NAID 10031179355
- Results of Emergency Coronary Artery Bypass Grafting for Acute Myocardial Infarction : Importance of Intraoperative and Postoperative Cardiac Medical Therapy
- Annals of thoracic and cardiovascular surgery 18(4), 338-346, 2012-08-01
- NAID 10031034323
- Pioglitazone Attenuates Inflammatory Atrial Fibrosis and Vulnerability to Atrial Fibrillation Induced by Pressure Overload in Rats
Related Links
- Atrial natriuretic peptide receptor. From Wikipedia, the free encyclopedia. Jump to : navigation, search. A atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide. Contents. 1 Mechanism; 2 Types; 3 References; 4 External links ...
- Receptors. Three types of atrial natriuretic peptide receptors have been identified on which natriuretic peptides act. They are all cell surface receptors and are designated: guanylyl cyclase-A (GC-A) also known as ...
★リンクテーブル★
[★]
- 関
- ANF receptor、atrial natriuretic factor receptor、atrial natriuretic peptide receptor
[★]
- 関
- ANP receptor、atrial natriuretic factor receptor
[★]
- 英
- atrial natriuretic factor receptor、ANF receptor
- 関
- 心房性ナトリウム利尿因子レセプター、ANFレセプター、ANF受容体、ANP受容体
[★]
- 英
- atrial natriuretic factor receptor、ANF receptor
- 関
- 心房性ナトリウム利尿因子受容体、ANFレセプター、ANF受容体
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
- 関
- atria、atrium、heart atria、heart atrium
[★]
- 関
- natriuresis
[★]