WordNet

the presence of abnormally large amounts of sodium in the urine
of or relating to natriuresis

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/15 17:01:20」(JST)

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Natriuresis is the process of excretion of sodium in the urine via action of the kidneys.^[1] Natriuresis is promoted (more sodium is excreted) by Brain and Atrial natriuretic peptides, and it is inhibited (sodium is conserved) by chemicals such as aldosterone. Natriuresis lowers the concentration of sodium in the blood and also tends to lower blood volume because osmotic forces make water follow sodium out of the body's blood circulation and into the urine. Many diuretic drugs take advantage of this mechanism to treat medical conditions like hypernatremia and hypertension.

Excess natriuresis can be caused by:

Medullary cystic disease
Bartter syndrome
Diuretic phase of acute tubular necrosis
Some diuretics
Primary renal diseases
Congenital adrenal hyperplasia
Syndrome of inappropriate antidiuretic hormone hypersecretion

References

^ "natriuresis". Merriam-Webster. Retrieved 23 December 2013.

Further reading

Granger, JP; Alexander, BT; Llinas, M (2002). "Mechanisms of pressure natriuresis". Current hypertension reports 4 (2): 152–9. doi:10.1007/s11906-002-0040-3. PMID 11884271.
Hall, J. E.; Mizelle, H. L.; Hildebrandt, D. A.; Brands, M. W. (1990). "Abnormal pressure natriuresis. A cause or a consequence of hypertension?". Hypertension 15 (6_Pt_1): 547–59. doi:10.1161/01.HYP.15.6.547. PMID 1971810.

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UpToDate Contents

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1. 塩分摂取量および塩分摂取量制限と原発性（本態性）高血圧 salt intake salt restriction and primary essential hypertension
2. 原発性アルドステロン症の病態生理および臨床的特徴 pathophysiology and clinical features of primary aldosteronism

English Journal

Pharmacokinetic and Pharmacodynamic Alterations in the Roux-en-Y Gastric Bypass Recipients.

Tandra S, Chalasani N, Jones DR, Mattar S, Hall SD, Vuppalanchi R.SourceDepartments of *Medicine and †General Surgery, Indiana University School of Medicine, Indianapolis, IN.
Annals of surgery.Ann Surg.2013 Aug;258(2):262-9. doi: 10.1097/SLA.0b013e31827a0e82.
OBJECTIVE: We conducted a pharmacokinetic (PK) study and a pharmacodynamic (PD) study to assess whether Roux-en-Y gastric bypass (RYGB) surgery is associated with significant changes to PK and PD of oral medications.BACKGROUND: The effect of RYGB on oral drug disposition is not well understood.METHO
PMID 23222033

Regulation of expression of atrial and brain natriuretic peptide, biomarkers for heart development and disease.

Sergeeva I, Christoffels VM.SourceDept of Anatomy, Embryology and Physiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jul 11. pii: S0925-4439(13)00241-X. doi: 10.1016/j.bbadis.2013.07.003. [Epub ahead of print]
The mammalian heart expresses two closely related natriuretic peptide (NP) hormones, atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP). The excretion of the NPs and the expression of their genes strongly respond to a variety of cardiovascular disorders. NPs act to increase natriure
PMID 23851052

Vasotocin analogues with selective natriuretic, kaliuretic and antidiuretic effects in rats.

Kutina AV, Marina AS, Shakhmatova EI, Natochin YV.SourceSechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 44 Thorez Pr., 194223 Saint-Petersburg, Russia. Electronic address: kutina_anna@mail.ru.
Regulatory peptides.Regul Pept.2013 Jul 5. pii: S0167-0115(13)00099-2. doi: 10.1016/j.regpep.2013.06.013. [Epub ahead of print]
The aim of the present study was an investigation of mechanisms mediating selective effect of vasotocin analogues on water, sodium, and potassium excretion. We tested vasotocin analogues: Mpa1-vasotocin (dAVT), Mpa1-Arg4-vasotocin (dAAVT) and Mpa1-DArg8-vasotocin (dDAVT). The effects on water, sodiu
PMID 23835093

Japanese Journal

Natriuretic peptide and exercise

Suda Kazuhiro
The Journal of Physical Fitness and Sports Medicine 2(3), 333-335, 2013
… NP causes diuresis, natriuresis and vasodilation. …
NAID 130003379975

Early Results of Human Atrial Natriuretic Peptide Infusion in Non-Dialysis Patients with Chronic Kidney Disease Undergoing Isolated Coronary Artery Bypass Grafting: the NU-HIT Trial for CKD-II

Sezai Akira,Nakata Kin-ichi,Iida Mitsuru,Yoshitake Isamu,Wakui Shinji,Hata Hiroaki,Shiono Motomi
Annals of Thoracic and Cardiovascular Surgery, 2013
… In the present study, a subanalysis was performed on patients registered in the NU-HIT trial for CKD from the standpoint of renin-angiotensin system, natriuresis and renal function.Methods: 303 patients with CKD who underwent isolated CABG were divided into a group that received carperitide infusion and another group without carperitide. …
NAID 130003377885

〈Original〉ANP Release Response to Prolonged Swimming in DOCA-salt Hypertensive Rats

Suda Kazuhiro,Takara Atsushi,Komabayashi Takao
Advances in exercise and sports physiology 18(3), 61-65, 2012-11-00
… ANP(atrial natriuretic peptide) dilates blood vessels and increases natriuresis, and eventually reduces blood pressure. …
NAID 110009561651