- 関
- ANP receptor
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- of or relating to a cavity or chamber in the body (especially one of the upper chambers of the heart)
- amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein
- of or relating to natriuresis
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/30 07:42:00」(JST)
[Wiki en表示]
An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.[1]
Contents
- 1 Mechanism
- 2 Types
- 3 References
- 4 External links
Mechanism
NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand.
ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG), which will then induce smooth muscle relaxation. This is particularly important in the vasculature, where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of the vasculature to relax. This relaxation will decrease total peripheral resistance, which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart's having to do less work.
There is also a soluble guanylyl cyclase that cannot be stimulated by ANP. Instead, vascular endothelial cells will use L-arginine to make nitric oxide via nitric oxide synthase. The nitric oxide will then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase. The subsequent increase in cGMP will cause vasodilation with the same effects as described above. This is why nitroglycerine is given to a person having a heart attack. The nitroglycerine will be metabolized to nitric oxide, which will stimulate soluble guanylyl cyclase. This will result in a decrease in total peripheral resistance and a decrease in preload on the heart. As a result, work done by the heart will decrease and will allow the heart to contract less strongly. Weaker contractions will lead to more blood flow in the coronary arteries, which will help the ischemic cardiac myocytes.
Types
There are three distinct atrial natriuretic factor receptors identified so far in mammals: natriuretic peptide receptors 1, 2, and 3.
| natriuretic peptide receptor A/ guanylate cyclase A (atrionatriuretic peptide receptor A) |
| Identifiers |
| Symbol |
NPR1 |
| Alt. symbols |
ANPRA, NPRA |
| Entrez |
4881 |
| HUGO |
7943 |
| OMIM |
108960 |
| RefSeq |
NM_000906 |
| UniProt |
P16066 |
| Other data |
| Locus |
Chr. 1 q21-q22 |
|
| natriuretic peptide receptor B/ guanylate cyclase B (atrionatriuretic peptide receptor B) |
| Identifiers |
| Symbol |
NPR2 |
| Alt. symbols |
ANPRB, NPRB |
| Entrez |
4882 |
| HUGO |
7944 |
| OMIM |
108961 |
| RefSeq |
NM_003995 |
| UniProt |
P20594 |
| Other data |
| Locus |
Chr. 9 p21-p12 |
|
| natriuretic peptide receptor C/ guanylate cyclase C (atrionatriuretic peptide receptor C) |
| Identifiers |
| Symbol |
NPR3 |
| Alt. symbols |
ANPRC, NPRC |
| Entrez |
4883 |
| HUGO |
7945 |
| OMIM |
108962 |
| RefSeq |
NM_000908 |
| UniProt |
P17342 |
| Other data |
| Locus |
Chr. 5 p14-p1 |
|
References
- ^ Hirose S, Hagiwara H, Takei Y (August 2001). "Comparative molecular biology of natriuretic peptide receptors". Can. J. Physiol. Pharmacol. 79 (8): 665–72. doi:10.1139/cjpp-79-8-665. PMID 11558675.
External links
- Atrial Natriuretic Factor Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Neuropeptide receptors
|
|
| G protein-coupled receptor |
| Hormone receptors |
| Hypothalamic |
- CRH
- FSH
- LHRH
- TRH
- Somatostatin
|
|
| Pituitary |
- Vasopressin
- Oxytocin
- LHCG
- TSH
|
|
| Other |
- Atrial natriuretic factor
- Calcitonin
- Cholecystokinin
- VIP
|
|
|
| Opioid receptors |
- Delta
- Kappa
- Mu
- Nociceptin
|
|
| Other neuropeptide receptors |
- Angiotensin
- Bradykinin
- Tachykinin
- Calcitonin gene-related peptide
- Galanin
- GPCR neuropeptide
- Neurotensin
|
|
|
| Type I cytokine receptor |
|
|
| Enzyme-linked receptor |
- Atrial natriuretic factor
|
|
| Other |
|
|
|
Index of signal transduction
|
|
| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
UpToDate Contents
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English Journal
- LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes.
- Cannon MV1, Silljé HH1, Sijbesma JW2, Khan MA1, Steffensen KR3, van Gilst WH1, de Boer RA4.
- Diabetologia.Diabetologia.2016 Mar;59(3):634-43. doi: 10.1007/s00125-015-3827-x. Epub 2015 Dec 18.
- AIMS/HYPOTHESIS: Diabetic cardiomyopathy is a myocardial disease triggered by impaired insulin signalling, increased fatty acid uptake and diminished glucose utilisation. Liver X receptors (LXRs) are key transcriptional regulators of metabolic homeostasis. However, their effect in the diabetic heart
- PMID 26684450
- Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.
- Kiguchi N1, Sukhtankar DD1, Ding H1, Tanaka K1, Kishioka S1, Peters CM1, Ko MC2.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2016 Mar;356(3):596-603. doi: 10.1124/jpet.115.229997. Epub 2015 Dec 15.
- B-type natriuretic peptide (BNP)-natriuretic peptide receptor A (NPRA) and gastrin-releasing peptide (GRP)-GRP receptor (GRPR) systems contribute to spinal processing of itch. However, pharmacological and anatomic evidence of these two spinal ligand-receptor systems are still not clear. The aim of t
- PMID 26669425
- Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway.
- Zhang X1, Ma S1, Zhang R2, Li S1, Zhu D1, Han D1, Li X1, Li C1, Yan W2, Sun D1, Xu B2, Wang Y3, Cao F4.
- Acta biochimica et biophysica Sinica.Acta Biochim Biophys Sin (Shanghai).2016 Feb 1. pii: gmv137. [Epub ahead of print]
- It has been reported that oncostatin M (OSM) could initiate cardiomyocyte dedifferentiation both in vivo and in vitro. OSM-induced cardiomyocyte dedifferentiation might be a new target for the treatment of diabetic cardiomyopathy (DCM). This study was designed to determine the role of OSM in cardiom
- PMID 26837420
Japanese Journal
- Addition of a Nitric Oxide Donor to an Angiotensin II Type 1 Receptor Blocker May Cancel Its Blood Pressure-Lowering Effects
- Novel Diuretic Strategies for the Treatment of Heart Failure in Japan
- Genetic factors associating the effects of habitual exercise on arterial stiffness
- The journal of physical fitness and sports medicine : JPFSM 2(3), 325-332, 2013-08-25
- NAID 10031179355
Related Links
- Introduction In 1981 Atrial Natriuretic Peptide was discovered by Adolfo J de Bold. ANP belongs to a family of peptides called the natriuretic peptide family which consists of Atrial Natriuretic Peptide(ANP), Brian Natriuretic Peptide ...
- Product Details: Atrial Natriuretic Peptide Receptor 3 (NPR3) Peptide - ABIN493174 Shipping to Login Comparison list Basket Help Language Antibodies ELISA Kits Secondary Antibodies Proteins Other Categories Suppliers ...
★リンクテーブル★
[★]
- 関
- ANF receptor、atrial natriuretic factor receptor、atrial natriuretic peptide receptor
[★]
- 英
- atrial natriuretic peptide receptor、ANP receptor
- 関
- ANP受容体、ANPレセプター、心房性ナトリウム利尿ペプチドレセプター
[★]
- 英
- atrial natriuretic peptide receptor、ANP receptor
- 関
- ANP受容体、ANPレセプター、心房性ナトリウム利尿ペプチド受容体
[★]
- 関
- atria、atrium、heart atria、heart atrium
[★]
- 関
- peptide hormone receptor
[★]
- 関
- natriuresis
[★]
[★]