- 関
- ANF receptor、atrial natriuretic factor receptor、atrial natriuretic peptide receptor
WordNet
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- answer / ampere
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/07 16:31:52」(JST)
[Wiki en表示]
An atrial natriuretic peptide receptor is a receptor for atrial natriuretic peptide.[1]
Contents
- 1 Mechanism
- 2 Types
- 3 References
- 4 External links
Mechanism
NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand.
ANP activation of the ANP catalytic receptor will stimulate its intracellular guanylyl cyclase activity to convert GTP to cGMP. cGMP will then stimulate cGMP-dependent protein kinase (PKG), which will then induce smooth muscle relaxation. This is particularly important in the vasculature, where vascular smooth muscle will bind ANP released as a result of increasing right atrial pressure and will cause the walls of the vasculature to relax. This relaxation will decrease total peripheral resistance, which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload and will result in the heart's having to do less work.
There is also a soluble guanylyl cyclase that cannot be stimulated by ANP. Instead, vascular endothelial cells will use L-arginine to make nitric oxide via nitric oxide synthase. The nitric oxide will then diffuse into the vascular smooth muscle and will activate the soluble guanylyl cyclase. The subsequent increase in cGMP will cause vasodilation with the same effects as described above. This is why nitroglycerine is given to a person having a heart attack. The nitroglycerine will be metabolized to nitric oxide, which will stimulate soluble guanylyl cyclase. This will result in a decrease in total peripheral resistance and a decrease in preload on the heart. As a result, work done by the heart will decrease and will allow the heart to contract less strongly. Weaker contractions will lead to more blood flow in the coronary arteries, which will help the ischemic cardiac myocytes.
Types
There are three distinct atrial natriuretic factor receptors identified so far in mammals: natriuretic peptide receptors 1, 2, and 3.
| natriuretic peptide receptor A/ guanylate cyclase A (atrionatriuretic peptide receptor A) |
| Identifiers |
| Symbol |
NPR1 |
| Alt. symbols |
ANPRA, NPRA |
| Entrez |
4881 |
| HUGO |
7943 |
| OMIM |
108960 |
| RefSeq |
NM_000906 |
| UniProt |
P16066 |
| Other data |
| Locus |
Chr. 1 q21-q22 |
|
| natriuretic peptide receptor B/ guanylate cyclase B (atrionatriuretic peptide receptor B) |
| Identifiers |
| Symbol |
NPR2 |
| Alt. symbols |
ANPRB, NPRB |
| Entrez |
4882 |
| HUGO |
7944 |
| OMIM |
108961 |
| RefSeq |
NM_003995 |
| UniProt |
P20594 |
| Other data |
| Locus |
Chr. 9 p21-p12 |
|
| natriuretic peptide receptor C/ guanylate cyclase C (atrionatriuretic peptide receptor C) |
| Identifiers |
| Symbol |
NPR3 |
| Alt. symbols |
ANPRC, NPRC |
| Entrez |
4883 |
| HUGO |
7945 |
| OMIM |
108962 |
| RefSeq |
NM_000908 |
| UniProt |
P17342 |
| Other data |
| Locus |
Chr. 5 p14-p1 |
|
References
- ^ Hirose S, Hagiwara H, Takei Y (August 2001). "Comparative molecular biology of natriuretic peptide receptors". Can. J. Physiol. Pharmacol. 79 (8): 665–72. doi:10.1139/cjpp-79-8-665. PMID 11558675.
External links
- Atrial Natriuretic Factor Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Neuropeptide receptors
|
|
| G protein-coupled receptor |
| Hormone receptors |
| Hypothalamic |
- CRH
- FSH
- LHRH
- TRH
- Somatostatin
|
|
| Pituitary |
- Vasopressin
- Oxytocin
- LHCG
- TSH
|
|
| Other |
- Atrial natriuretic factor
- Calcitonin
- Cholecystokinin
- VIP
|
|
|
| Opioid receptors |
- Delta
- Kappa
- Mu
- Nociceptin
|
|
| Other neuropeptide receptors |
- Angiotensin
- Bradykinin
- Tachykinin
- Calcitonin gene-related peptide
- Galanin
- GPCR neuropeptide
- Neurotensin
|
|
|
| Type I cytokine receptor |
|
|
| Enzyme-linked receptor |
- Atrial natriuretic factor
|
|
| Other |
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Effect of Chaiqin Chengqi Decoction () on cholecystokinin receptor 1-mediated signal transduction of pancreatic acinar cells in acute necrotizing pancreatitis rats.
- Guo J1, Jin T, Lin ZQ, Wang XX, Yang XN, Xia Q, Xue P.
- Chinese journal of integrative medicine.Chin J Integr Med.2015 Jan;21(1):29-35. doi: 10.1007/s11655-014-1750-5. Epub 2014 May 10.
- OBJECTIVE: To investigate the effect of Chaiqin Chengqi Decoction (,CQCQD) on cholecystokinin receptor 1 (CCKR1)-mediated signal transduction of pancreatic acinar cell in rats with acute necrotic pancreatitis (ANP).METHODS: Twenty-seven Sprague-Dawley rats were randomized into three groups: the cont
- PMID 24817315
- Liraglutide promotes natriuresis but does not increase circulating levels of atrial natriuretic Peptide in hypertensive subjects with type 2 diabetes.
- Lovshin JA1, Barnie A2, DeAlmeida A3, Logan A1, Zinman B4, Drucker DJ5.
- Diabetes care.Diabetes Care.2015 Jan;38(1):132-9. doi: 10.2337/dc14-1958. Epub 2014 Nov 20.
- OBJECTIVE: GLP-1 receptor (GLP-1R) agonists induce natriuresis and reduce blood pressure (BP) through incompletely understood mechanisms. We examined the effects of acute and 21-day administration of liraglutide on plasma atrial natriuretic peptide (ANP), urinary sodium excretion, office and 24-h BP
- PMID 25414155
- Role of atrial natriuretic Peptide in oxytocin induced cardioprotection.
- Houshmand F1, Faghihi M2, Zahediasl S3.
- Heart, lung & circulation.Heart Lung Circ.2015 Jan;24(1):86-93. doi: 10.1016/j.hlc.2014.05.023. Epub 2014 Jun 30.
- BACKGROUND: The purpose of this study was to determine whether endogenous atrial natriuretic peptide (ANP) contributes to the protective effect of neurohypophysial hormone oxytocin (OT) in heart preconditioning.METHODS: Sprague-Dawley male rats were subjected to 25min regional ischaemia and 120min r
- PMID 25126708
Japanese Journal
- Angiotensin Ⅱ receptor・neprilysin同時拮抗剤 : LCZ696について
- Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats
- A-Type Natriuretic Peptide Level in Angiotensin Ⅱ Type 1a Receptor Knockout Mice
Related Links
- Natriuretic peptide receptors – Molecular topology The hormonal activities of ANP and BNP are mediated by the A-type natriuretic peptide receptor (NPRA). The NPRA is a single transmembrane segment receptor linked ...
- Design and Synthesis of Gentiohexaosyl Derivatives for an ANP Receptor Antagonist, HS-142-1 QIU Yi The Institute of Physical and Chemical Research (RIKEN) NAKAHARA Yoshiaki The Institute of Physical and Chemical ...
★リンクテーブル★
[★]
- 英
- ANP receptor
- 関
- 心房性ナトリウム利尿因子受容体、ANPレセプター、心房性ナトリウム利尿ペプチドレセプター、心房性ナトリウム利尿ペプチド受容体
[★]
- 関
- ANP receptor、atrial natriuretic factor receptor
[★]
- 英
- atrial natriuretic peptide receptor、ANP receptor
- 関
- ANP受容体、ANPレセプター、心房性ナトリウム利尿ペプチドレセプター
[★]
- 英
- atrial natriuretic peptide receptor、ANP receptor
- 関
- ANP受容体、ANPレセプター、心房性ナトリウム利尿ペプチド受容体
[★]
- 英
- ANP receptor
- 関
- ANP受容体、心房性ナトリウム利尿ペプチドレセプター、心房性ナトリウム利尿ペプチド受容体
[★]
[★]
[★]
心房性ナトリウム利尿ペプチド atrial natriuretic peptide