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1. リポ蛋白aと心血管疾患lipoprotein a and cardiovascular disease [show details]
… glycoprotein, apolipoprotein(a) (apo(a)), is covalently bound to apolipoprotein B by a disulfide bridge . The apo(a) chain contains five cysteine-rich domains known as "kringles" . The fourth kringle is …
2. 一次予防のための心血管疾患の発症リスクの評価：危険因子の計算ツールcardiovascular disease risk assessment for primary prevention risk calculators [show details]
… measurement of various apolipoproteins (apo) A-1 and B. There are numerous studies examining the power of each of these various lipoproteins in predicting CHD risk. There is generally a consensus that non-HDL …
3. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割lipoprotein classification metabolism and role in atherosclerosis [show details]
…range is predominantly comprised of apo A-I HDL particles (HDL-VL, HDL-L, HDL-M) and the HDL3 density range is predominantly comprised of particles containing apo A-I and A-II (HDL-S, HDL-VS). Another method …
4. Gene test interpretation: Familial hypercholesterolemia genes (LDLR, APOB, PCSK9)gene test interpretation familial hypercholesterolemia genes ldlr apob pcsk9 [show details]
5. HDLコレステロール：異常値の臨床的側面hdl cholesterol clinical aspects of abnormal values [show details]
…human apolipoprotein A-1 by somatic gene transfer of apolipoprotein A-1 , by the administration of oral apo A-1 mimetic peptides , or by the administration of apolipoprotein A-1 Milano, which is a natural …

English Journal

Sterically stabilized recombined HDL composed of modified apolipoprotein A-I for efficient targeting toward glioma cells.

Li J, Han M, Li J, Ge Z, Wang Q, Zhou K, Yin X.
Drug delivery. 2020 Dec;27(1)530-541.
Reconstituted high density lipoprotein (rHDL) has been regarded as a promising brain-targeting vehicle for anti-glioma drugs under the mediation of apolipoprotein A-I (apoA-I). However, some stability issues relating to drug leakage and consequent reduced targeting efficiency in the course of discoi
PMID 32241173

Comprehensive Proteomic Profiling of Pressure Ulcers in Patients with Spinal Cord Injury Identifies a Specific Protein Pattern of Pathology.

Baldan-Martin M, Martin-Rojas T, Corbacho-Alonso N, Lopez JA, Sastre-Oliva T, Gil-Dones F, Vazquez J, Arevalo JM, Mourino-Alvarez L, Barderas MG.
Advances in wound care. 2020 05;9(5)277-294.
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PMID 32226651

High-density lipoproteins during sepsis: from bench to bedside.

Tanaka S, Couret D, Tran-Dinh A, Duranteau J, Montravers P, Schwendeman A, Meilhac O.
Critical care (London, England). 2020 04;24(1)134.
High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver conferring them a cardioprotective function. HDLs also display pleiotropic properties i
PMID 32264946

Japanese Journal

High-Density Lipoprotein Mimetics: a Therapeutic Tool for Atherosclerotic Diseases

Ikenaga Masahiro,Higaki Yasuki,Saku Keijiro,Uehara Yoshinari
Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 23(4), 385-394, 2016
… Clinical trials and epidemiological studies have revealed a negative correlation between serum high-density lipoprotein (HDL) cholesterol levels and the risk of cardiovascular events. … HDL therapies using HDL mimetics, including reconstituted HDL, apolipoprotein (Apo) A-IMilano, ApoA-I mimetic peptides, or full-length ApoA-I, are highly effective in animal models. …
NAID 130005141419

High-Density Lipoprotein-Targeted Therapy and Apolipoprotein A-I Mimetic Peptides

Uehara Yoshinari,Chiesa Giulia,Saku Keijiro
日本循環器學誌 79(12), 2523-2528, 2015
… The reverse cholesterol transport pathway, mediated by HDL particles, has a relevant antiatherogenic potential. … HDL therapies using reconstituted HDL, including apolipoprotein (Apo) A-I Milano, ApoA-I mimetics, or full-length ApoA-I, are dramatically effective in animal models. …
NAID 130005110908

Citrulline increases cholesterol efflux from macrophages in vitro and ex vivo via ATP-binding cassette transporters

Uto-Kondo Harumi,Komatsu Tomohiro,Sotherden Grace Megumi,Hosoai Tamaki,Sakurada Masami,Ikewaki Katsunori,Ayaori Makoto,Nakaya Kazuhiro,Takiguchi Shunichi,Yakushiji Emi,Ogura Masatsune,Terao Yoshio,Ozasa Hideki,Sasaki Makoto
Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 55(1), 32-39, 2014
… Reverse cholesterol transport (RCT) is a mechanism critical to the anti-atherogenic property of HDL. … This study was undertaken to clarify the effects of citrulline on expressions of specific transporters such as ATP binding cassette transporters (ABC)A1 and ABCG1, and the cholesterol efflux from macrophages to apolipoprotein (apo) A-I or HDL in vitro …
NAID 130004466761