WordNet
- a substance that exerts some force or effect
- a businessman who buys or sells for another in exchange for a commission (同)factor, broker
- any agent or representative of a federal agency or bureau (同)federal agent
- a representative who acts on behalf of other persons or organizations
- an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
- how long something has existed; "it was replaced because of its age"
- a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
- begin to seem older; get older; "The death of his wife caused him to age fast"
- make older; "The death of his child aged him tremendously"
- a drug used to relieve or prevent spasms (especially of the smooth muscles) (同)spasmolytic, antispasmodic_agent
PrepTutorEJDIC
- 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
- 〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる
UpToDate Contents
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- 1. Treatment of irritable bowel syndrome in adults
- 2. 女性の転移性乳癌に対する全身療法：化学療法 systemic treatment of metastatic breast cancer in women chemotherapy
- 3. 上皮性卵巣癌、卵管癌、または腹膜癌の再発に対する薬物療法：プラチナ製剤感受性癌 medical treatment for relapsed epithelial ovarian fallopian tubal or peritoneal cancer platinum sensitive disease
- 4. 症候性または進行した慢性リンパ性白血病に対する初期治療の選択 selection of initial therapy for symptomatic or advanced chronic lymphocytic leukemia
- 5. 成人造血細胞移植レシピエントにおける侵襲性真菌感染症予防 prophylaxis of invasive fungal infections in adult hematopoietic cell transplant recipients
English Journal
- Smoking Crushed Hyoscine/Scopolamine Tablets as Drug Abuse.
- Jalali F, Afshari R, Babaei A.Author information 1Addiction Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.AbstractBackground: Hyoscine N-butyl bromide/scopolamine (H/S) is a type of anticholinergic agent that is commonly used as an antispasmodic drug. We have evaluated the effects of crushed H/S smoking in prisoners who illicitly abused this drug. Methods: All imprisoned cases with at least a 3-month history of HS were evaluated from April 2012 to September 2012. Demographic information, history, and clinical findings were studied. Results: In total, 36 male cases with a mean (SD, min-max) age of 33.3 (3.6, 27-42) years were included. All subjects were cigarette smokers with a history of substance abuse and were under Methadone Maintenance Therapy (MMT). The majority (75%) of participants smoked H/S tablet with pin, and others used aluminum foil. Hallucinations were the most common neurological features. Amnesia (88%), insomnia (83%), palpitation (86%), flushing (86%), irritability (94%), and inability to concentrate (91%) were the most common findings. Among them, auditory (61%), visual (72%), and tactile (72%) hallucinations were reported. Conclusions: This is the first case study of hyoscine smoking abuse. We found that H/S acts similar to other hallucinogens. Concurrent abuse of H/S in cases under MMT could be a future trend of abuse. Clinicians should be aware of abuse potential of H/S in treatment of some patients for drug overdose.
- Substance use & misuse.Subst Use Misuse.2014 Feb 4. [Epub ahead of print]
- Background: Hyoscine N-butyl bromide/scopolamine (H/S) is a type of anticholinergic agent that is commonly used as an antispasmodic drug. We have evaluated the effects of crushed H/S smoking in prisoners who illicitly abused this drug. Methods: All imprisoned cases with at least a 3-month history of
- PMID 24494624
- Serum concentration of eperisone hydrochloride correlates with QT interval.
- Yamagiwa T1, Morita S2, Amino M3, Miura N2, Saito T2, Inokuchi S2.Author information 1Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, Japan. Electronic address: yamagiwa@is.icc.u-tokai.ac.jp.2Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, Japan.3Department of Emergency and Critical Care Medicine, Tokai University School of Medicine, Kanagawa, Japan; Department of Cardiology, Tokai University School of Medicine, Kanagawa, Japan.AbstractBACKGROUND: Eperisone hydrochloride is a centrally acting muscle relaxant prescribed for muscle stiffness that acts by depressing the activities of α and γ efferent neurons in the spinal cord and supraspinal structures. Although a case of eperisone-induced severe QT prolongation had been reported, the relationship between serum eperisone concentration and QT interval remains obscure.
- The American journal of emergency medicine.Am J Emerg Med.2014 Jan;32(1):75-7. doi: 10.1016/j.ajem.2013.09.006. Epub 2013 Oct 15.
- BACKGROUND: Eperisone hydrochloride is a centrally acting muscle relaxant prescribed for muscle stiffness that acts by depressing the activities of α and γ efferent neurons in the spinal cord and supraspinal structures. Although a case of eperisone-induced severe QT prolongation had been reported,
- PMID 24135462
- Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist.
- Desai RI, Grandy DK, Lupica CR, Katz JL.Author information Psychobiology Section (R.I.D., J.L.K.) and Electrophysiology Research Section (C.R.L.), National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland; and Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon (D.K.G.).AbstractAn N-butyl analog of benztropine, JHW007 [N-(n-butyl)-3α-[bis(4'-fluorophenyl)methoxy]-tropane], binds to dopamine transporters (DAT) but has reduced cocaine-like behavioral effects and antagonizes various effects of cocaine. The present study further examined mechanisms underlying these effects. Cocaine dose-dependently increased locomotion, whereas JHW007 was minimally effective but increased activity 24 hours after injection. JHW007 (3-10 mg/kg) dose-dependently and fully antagonized the locomotor-stimulant effects of cocaine (5-60 mg/kg), whereas N-methyl and N-allyl analogs and the dopamine (DA) uptake inhibitor GBR12909 [1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride] stimulated activity and failed to antagonize effects of cocaine. JHW007 also blocked the locomotor-stimulant effects of the DAT inhibitor GBR12909 but not stimulation produced by the δ-opioid agonist SNC 80 [4-[(R)-[(2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide], which increases activity through nondopaminergic mechanisms. JHW007 blocked locomotor-stimulant effects of cocaine in both DA D2- and CB1-receptor knockout and wild-type mice, indicating a lack of involvement of these targets. Furthermore, JHW007 blocked effects of cocaine on stereotyped rearing but enhanced stereotyped sniffing, suggesting that interference with locomotion by enhanced stereotypies is not responsible for the cocaine-antagonist effects of JHW007. Time-course data indicate that administration of JHW007 antagonized the locomotor-stimulant effects of cocaine within 10 minutes of injection, whereas occupancy at the DAT, as determined in vivo, did not reach a maximum until 4.5 hours after injection. The σ1-receptor antagonist BD 1008 [N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1-pyrrolidinyl)ethylamine dihydrobromide] blocked the locomotor-stimulant effects of cocaine. Overall, these findings suggest that JHW007 has cocaine-antagonist effects that are deviate from its DAT occupancy and that some other mechanism, possibly σ-receptor antagonist activity, may contribute to the cocaine-antagonist effect of JHW007 and like drugs.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2014 Jan;348(1):106-15. doi: 10.1124/jpet.113.208538. Epub 2013 Nov 5.
- An N-butyl analog of benztropine, JHW007 [N-(n-butyl)-3α-[bis(4'-fluorophenyl)methoxy]-tropane], binds to dopamine transporters (DAT) but has reduced cocaine-like behavioral effects and antagonizes various effects of cocaine. The present study further examined mechanisms underlying these effects. C
- PMID 24194528
Japanese Journal
- 上部消化管内視鏡検査の鎮痙剤としてペパーミントオイルは有用である : 内視鏡医, 患者, 看護師, それぞれの立場から
- 水野 順子,引地 拓人,鈴木 孝子,伊藤 江美子,雷 毅,国分 正恵,佐藤 和典,斎藤 光正
- 福島醫學雜誌 57(1), 9-16, 2007-03-26
- NAID 10026160669
- Antispasmodic Activity of Fractions and Cynaropicrin from Cynara scolymus on Guinea-Pig Ileum(Pharmacology)
- EMENDORFER Fernanda,EMENDORFER Fabiane,BELLATO Fernanda,NOLDIN Vania Floriani,CECHINEL FILHO Valdir,YUNES Rosendo Augusto,MONACHE Franco Delle,CARDOZO Alcibia Maia
- Biological & pharmaceutical bulletin 28(5), 902-904, 2005-05-01
- … This study describes the antispasmodic activity of some fractions and cynaropicrin, a sesquiterpene lactone from Cynara scolymus, cultivated in Brazil, against guinea-pig ileum contracted by acetylcholine. … of 0.065 (0.049-0.086) mg/ml, being about 14-fold more active than dichloromethane fraction and having similar potency to that of papaverine, a well-known antispasmodic agent. …
- NAID 10016663536
Related Links
- Translate antispasmodic agent into another language Relevant Questions Whats The Definition Of Antispasmodic Agent? What Does Antispasmodic Agent Mean? What Are Symptoms Of Antispasmodic Agent? What Is The ...
- n a drug used to relieve or prevent spasms (especially of the smooth muscles) Synonyms: antispasmodic, spasmolytic Types: atropine a poisonous crystalline alkaloid extracted from the nightshade family; used as an antispasmodic ...
Related Pictures
★リンクテーブル★
| リンク元 | 「鎮痙薬」「spasmolytic」「antispasmodic drug」「parasympatholytics」「antispastic drug」 |
| 関連記事 | 「agent」「antispasmodic」「age」 |
「鎮痙薬」
- 英
- antispasmodic agent、antispastic drug、antispasmodic drug、spasmolytic、antispasmodic
- 関
- 鎮痙、鎮痙剤、副交感神経遮断薬
「spasmolytic」
- 関
- antispasmodic、antispasmodic agent、antispasmodic drug、antispasmodics、antispastic drug、parasympatholytics
「antispasmodic drug」
「parasympatholytics」
「antispastic drug」
「agent」
- n.
- 代行者、代理人。代理業者
- 政府職員、官吏
- ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、～剤。病原体
- 関
- agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle
「antispasmodic」
- adj.
- 鎮痙の
- n.
- 関
- antispasmodic agent、antispasmodic drug、antispasmodics、antispastic、antispastic drug、spasmolysis、spasmolytic
「age」
- n.
- 年齢、歳
- v.
- 加齢する、熟成する