分化型急性骨髄芽球性白血病
WordNet
- a measure of the money supply; M1 plus net time deposits (other than large certificates of deposit)
- of critical importance and consequence; "an acute (or critical) lack of research funds"
- having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
- extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
- having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
- of an angle; less than 90 degrees
- a message whose ingenuity or verbal skill or incongruity has the power to evoke laughter (同)humor, humour, witticism, wittiness
- malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer (同)leukaemia, leucaemia, cancer of the blood
- coming to full development; becoming mature (同)ripening, maturement
PrepTutorEJDIC
- (先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
- 《随伴・協調》…『と』,と共に,といっしょに / 《所有・所持》…『を持っている』,がある,の付いた / 《道具・手段》…『で』,を使って / 《財料・供給物》…『で』,を与えて / …を支持して,に賛成して / …『に反対(敵対)して』,を相手として / …『と同時に』,と同様に / …『に比べて』,に比例して / 《様態》《名詞を伴い副詞句として》『…で』,を示して,をもって / 《付帯状競》…『して』,しながら / 《譲歩》…がありながら,にもかかわらず / 『…が原因で』,のために,…で / …に任せて,のもとにあずけて,のところに / …に関して,について / …から離れて / 《連結・混合》…と / 《副詞と共に命令文で》
- 知る(know)
- 〈U〉『機知』,機転,ウィット / 〈C〉『機知に富む人』,機転のきく人 / 《複数形で;単数扱い》『理解(表現)力』,知性 / 《複数形で》(物事を見抜いたりもくろんだりする)才覚,才知 / 《複数形で;単数扱い》正気
- 白血病
- 成熟,円熟
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/15 10:08:15」(JST)
[Wiki en表示]
| Acute myeloblastic leukemia with maturation |
| Classification and external resources |
Myeloblast
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| ICD-O: |
M9874/3 |
| MeSH |
D015470 |
Main article: Acute myeloid leukemia
M2 is a subtype of AML (Acute Myeloid Leukemia).
It is also known as "Acute Myeloblastic Leukemia with Maturation".[1]
Cause[edit]
This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21).[2] On both sides of the splice the DNA coded for different proteins, RUNX1 and ETO, These two sequences are then transcribed and translated into a single large protein, "M2 AML" which allows the cell to divide unchecked, leading to cancer.
References[edit]
- ^ "Acute Myeloid Leukemia - Signs and Symptoms".
- ^ Taj AS, Ross FM, Vickers M, et al. (1995). "t(8;21) myelodysplasia, an early presentation of M2 AML". Br. J. Haematol. 89 (4): 890–2. doi:10.1111/j.1365-2141.1995.tb08429.x. PMID 7772527.
External links[edit]
- Histology at University of Virginia
- Images at Nagoya University
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Myeloid hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
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CFU-GM/
and other granulocytes |
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CFU-GM
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Myelocyte
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AML: Acute myeloblastic leukemia (M0, M1, M2), APL/M3
MP (Chronic neutrophilic leukemia)
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Monocyte
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AML (AMoL/M5, Myeloid dendritic cell leukemia)
CML (Philadelphia chromosome, Accelerated phase chronic myelogenous leukemia)
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Myelomonocyte
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AML (M4)
MD-MP (Juvenile myelomonocytic leukemia, Chronic myelomonocytic leukemia)
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Other
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Histiocytosis
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CFU-Baso
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AML (Acute basophilic)
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CFU-Eos
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AML (Acute eosinophilic)
MP (Chronic eosinophilic leukemia/Hypereosinophilic syndrome)
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| MEP |
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CFU-Meg
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AML (AMKL/M7)
MP (Essential thrombocytosis)
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CFU-E
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AML (Erythroleukemia/M6)
MP (Polycythemia vera)
MD (Refractory anemia, Refractory anemia with excess of blasts, Chromosome 5q deletion syndrome, Sideroblastic anemia, Paroxysmal nocturnal hemoglobinuria, Refractory cytopenia with multilineage dysplasia)
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| CFU-Mast |
Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Mastocytosis: Diffuse cutaneous mastocytosis · Erythrodermic mastocytosis · Generalized eruption of cutaneous mastocytosis (adult type) · Generalized eruption of cutaneous mastocytosis (childhood type) · Mast cell sarcoma · Solitary mastocytoma · Systemic mastocytosis · Xanthelasmoidal mastocytosis
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| Multiple/unknown |
AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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Pathology: chromosome abnormalities (Q90–Q99, 758)
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| Autosomal |
| Trisomies |
- Down syndrome
- Edwards syndrome
- Patau syndrome
- Trisomy 9
- Warkany syndrome 2
- Cat eye syndrome
- Trisomy 16
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| Monosomies/deletions |
- 1q21.1 deletion syndrome/1q21.1 duplication syndrome/TAR syndrome
- Wolf-Hirschhorn syndrome
- Cri du chat/Chromosome 5q deletion syndrome
- Williams syndrome
- Jacobsen syndrome
- Miller–Dieker syndrome/Smith–Magenis syndrome
- DiGeorge syndrome
- 22q11.2 distal deletion syndrome
- 22q13 deletion syndrome
- genomic imprinting
- Angelman syndrome/Prader–Willi syndrome (15)
- Distal 18q-/Proximal 18q-
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| X/Y linked |
| Monosomy |
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Trisomy/tetrasomy,
other karyotypes/mosaics |
- Klinefelter syndrome (47,XXY)
- 48,XXYY
- 48,XXXY
- 49,XXXYY
- 49,XXXXY
- Triple X syndrome (47,XXX)
- 48,XXXX
- 49,XXXXX
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| Translocations |
| Leukemia/lymphoma |
| Lymphoid |
- Burkitt's lymphoma t(8 MYC;14 IGH)
- Follicular lymphoma t(14 IGH;18 BCL2)
- Mantle cell lymphoma/Multiple myeloma t(11 CCND1:14 IGH)
- Anaplastic large cell lymphoma t(2 ALK;5 NPM1)
- Acute lymphoblastic leukemia
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| Myeloid |
- Philadelphia chromosome t(9 ABL; 22 BCR)
- Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1)
- Acute promyelocytic leukemia t(15 PML,17 RARA)
- Acute megakaryoblastic leukemia t(1 RBM15;22 MKL1)
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| Other |
- Ewing's sarcoma t(11 FLI1; 22 EWS)
- Synovial sarcoma t(x SYT;18 SSX)
- Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB)
- Myxoid liposarcoma t(12 DDIT3; 16 FUS)
- Desmoplastic small round cell tumor t(11 WT1; 22 EWS)
- Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)
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| Other |
- Fragile X syndrome
- Uniparental disomy
- XX male syndrome
- Ring chromosome (13; 14; 15; 20)
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UpToDate Contents
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English Journal
- Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.
- Mollet L, Robinet P, Dubois M, Aurouet A, Normand T, Charpentier S, Sureau A, Grandclement C, Garnache-Ottou F, Deconinck E, Brulé F, Rohrlich PS, Legrand A.SourceCentre de Biophysique Moléculaire, CNRS UPR 4301, affiliated with the Université d'Orléans - Pôle Universitaire Centre Val de Loire, Rue Charles Sadron, 45071 Orléans Cedex 2, France. Electronic address: lucile.mollet@cnrs-orleans.fr.
- Molecular immunology.Mol Immunol.2013 Nov;56(1-2):123-8. doi: 10.1016/j.molimm.2013.04.012. Epub 2013 May 25.
- GALIG gene expression induces apoptosis in cultured cells through a pathway still under investigation. It is highly expressed in leukocytes but weakly detectable in bone marrow, suggesting a role in the myeloid lineage homeostasis. We show here that GALIG-induced cell death is counteracted by the ov
- PMID 23711389
- Inactivation of PTEN increases ABCG2 expression and the side population through the PI3K/Akt pathway in adult acute leukemia.
- Huang FF, Wu DS, Zhang L, Yu YH, Yuan XY, Li WJ, Chen XP, Zhao XL, Chen FP, Zeng H.SourceDepartment of Hematology, Xiang-Ya Hospital, Central South University, Changsha, Hunan, China.
- Cancer letters.Cancer Lett.2013 Aug 9;336(1):96-105. doi: 10.1016/j.canlet.2013.04.006. Epub 2013 Apr 16.
- Both the occurrence and recurrence of acute leukemia (AL) might suggest the presence of leukemia stem cells. Side population (SP) cells, exhibiting stem cell-like properties, express ABCG2 (breast cancer resistance protein [BCRP]). This study revealed that over-expression of ABCG2 in Jurkat and HL60
- PMID 23603434
- Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.
- Hinterleitner C, Huelsenbeck J, Henninger C, Wartlick F, Schorr A, Kaina B, Fritz G.SourceInstitute of Toxicology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str 67, 55131, Mainz, Germany.
- Apoptosis : an international journal on programmed cell death.Apoptosis.2013 Aug;18(8):963-79. doi: 10.1007/s10495-013-0842-6.
- We investigated the relevance of signaling mechanisms regulated by the Ras-homologous GTPase Rac1 for survival of acute myeloid leukemia (AML) cells harbouring the MLL-AF9 oncogene due to t(9;11)(p21;q23) translocation. Monocytic MLL-AF9 expressing cells (MM6, THP-1) were hypersensitive to both smal
- PMID 23624644
Japanese Journal
- 多剤併用化学療法により維持管理可能であった未分化型骨髄芽球性白血病(M1)の猫の1例(内科学)
- 真下 忠久,下田 哲也,吉岡 永朗 [他],高橋 靖,光田 昌史
- The journal of veterinary medical science 68(1), 97-101, 2006-01-25
- 2歳, 雄の雑種猫が元気および食欲低下を主訴に来院した.血液検査では, 軽度の非再生性貧血, 血小板減少症, および多数の芽球出現を伴う白血球増加が認められた.骨髄検査では, 同様の芽球の増加を認めた.これらの細胞はペルオキシダーゼ染色陽性であり, FAB分類にしたがい未分化型骨髄芽球性白血病(M1)と診断した.シクロホスファミド, ビンクリスチン, プレドニゾロン, およびシタラビンを用いた多剤 …
- NAID 110004675703
- A Cat with Acute Myeloblastic Leukemia without Maturation (M1) Treated with Combination Chemotherapy
- , , , ,
- Journal of Veterinary Medical Science 68(1), 97-101, 2006
- … A 2-year-old domestic shorthair cat was presented to us with decreased activity and anorexia. … Hematologic findings revealed a mild non-regenerative anemia, thrombocytopenia, and leukocytosis with an increase in blast cells. … Acute myeloblastic leukemia without maturation (M1) was diagnosed according to the FAB classification. …
- NAID 130000448096
- 多剤併用化学療法により完全寛解が得られ1年間生存した分化型骨髄芽球性白血病の猫の1例
- 高橋 義明,平川 篤,柴山 比奈子,大道 嘉広,山本 直人,深津 豪,高木 仁,吉田 進太郎
- 日本獣医師会雑誌 58(6), 405-408, 2005
- 元気食欲の低下および嘔吐を主訴に来院したFeLV陽性の雑種猫に重度の汎血球減少症を認めた.骨髄検査および細胞化学染色により分化型骨髄芽球性白血病 (M2) と診断した. ビンクリスチン, ダウノルビシン, シトシンアラビノシドおよびプレドニゾロンを用いた多剤併用化学療法により完全寛解が得られ, シトシンアラビノシド少量療法により良好に維持された. しかし, 第346病日に貧血, 血小板減少症および …
- NAID 130004052449
Related Links
- M2 is a subtype of AML (Acute Myeloid Leukemia). It is also known as "Acute Myeloblastic Leukemia with Maturation". [1] Cause This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written ...
- Home Chapter Home Jobs Conferences Fellowships Books Advertisement Leukemia - Acute AML not otherwise categorized Acute myeloid leukemia with maturation (FAB AML M2) Reviewer: Daniela Mihova, M.D. (see Reviewers page)
★リンクテーブル★
[★]
- 英
- acute myeloblastic leukemia with maturation, acute myeloblastic leukemia, with granulocytic maturation, (FAB分類)M2
- 関
- 急性骨髄性白血病, acute myeloid leukemia with maturation and with t(8,21)
- アズール顆粒が見られる。
- アウエル小体も見られる。
- 前骨髄球にまで分化したものはアズール顆粒を有しており、そうでない物は骨髄芽球と考えられる。
- 核内には明るく抜けた核小体が1-3,4個みられる。
- M2が分化した物が混在しているのに対して、M3は前骨髄球に分化したものばかり見られるという、M3ではアズール顆粒が著明、M3でアズール小体が複数見られる点で異なる、と思われる。
参考
- 1. 血液検査コーナー Clinical Case Study 04.急性骨髄性白血病 AML：M2/ベックマン・コールター
- http://www.beckmancoulter.co.jp/hematology/clinical_cs/cs04.html
[★]
(FAB分類)分化型急性骨髄芽球性白血病, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia, with granulocytic maturation
[★]
- (疾患)急性の、急性型の、急性的な。(形状が)鋭い、鋭角の。(感覚、才知などが)鋭い。明敏な、鋭い眼識のある。
- 関
- acutely、quick、sharp
[★]
- 関
- maturational、mature、maturing、ripening
[★]
- 関
- myeloblast