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1. 赤血球細胞膜：構造、機構、動態red blood cell membrane structure organization and dynamics [show details]
… lipid bilayer ; Adducin is a target for the calcium-dependent regulatory protein calmodulin; as a result, its ability to promote spectrin-actin interactions is regulated by the intracellular calcium concentration…
2. 血小板生物学platelet biology [show details]
… The cytoplasmic actin network is composed of actin filaments and associated proteins. Actin is a 42 kDa protein which accounts for as much as 20 percent of total platelet protein .… have a regulatory effect on the phosphorylated protein, perhaps by causing a conformational change, or it can provide a binding site for modular domains located in other proteins,…
3. 肥大型心筋症：遺伝子変異および臨床遺伝子検査hypertrophic cardiomyopathy gene mutations and clinical genetic testing [show details]
… encoding the gamma-2 regulatory subunit of adenosine monophosphate (AMP)-activated protein kinase (PRKAG2) and lysosome-associated membrane protein 2 (LAMP2) have been… myosin binding protein-C; Cardiac alpha and beta-myosin heavy chain; Cardiac alpha actin; Alpha tropomyosin; Titin; In addition,…
4. T細胞受容体シグナル伝達t cell receptor signaling [show details]
… domain-containing 76-kDa leukocyte protein (SLP-76). Further signaling proteins are then recruited, resulting in calcium mobilization, actin cytoskeleton reorganization,… negative regulatory phosphorylation by the c-Src kinase (Csk), leading to a "closed" conformation of Lck. The phosphorylated residue is bound by the Lck SH2 domain, folding up the protein into a conformation…
5. デスモイド腫瘍：疫学、危険因子、分子学的病因、臨床症状、診断、および局所療法desmoid tumors epidemiology risk factors molecular pathogenesis clinical presentation diagnosis and local therapy [show details]
… lead to premature truncation of the APC protein and loss of the beta-catenin regulatory domain.… The spindle cells usually stain for vimentin and smooth muscle actin and nuclear beta-catenin but are generally negative for desmin,…

English Journal

Glia maturation factor-γ regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS.

Aerbajinai W, Ghosh MC, Liu J, Kumkhaek C, Zhu J, Chin K, Rouault TA, Rodgers GP.
Blood advances. 2019 Apr;3(8)1211-1225.
In macrophages, cellular iron metabolism status is tightly integrated with macrophage phenotype and associated with mitochondrial function. However, how molecular events regulate mitochondrial activity to integrate regulation of iron metabolism and macrophage phenotype remains unclear. Here, we expl
PMID 30971398

Nonmuscle myosin-2 isoforms.

Sellers JR, Heissler SM.
Current biology : CB. 2019 Apr;29(8)R275-R278.
A hallmark of eukaryotes is the ability to generate microscale movements from the molecular to the tissue-length scales. Members of the myosin and actin protein families form the actomyosin cytoskeleton and are responsible for these movements. The cytoskeleton is a diffuse and dynamic network made u
PMID 31014482

CAMSAP2 is a microtubule minus-end targeting protein (-TIP) that regulates BTB dynamics through cytoskeletal organization.

Mao BP, Li L, Ge R, Li C, Wong CKC, Silvestrini B, Lian Q, Cheng CY.
Endocrinology. 2019 Apr;().
During spermatogenesis, microtubule (MT) cytoskeleton in Sertoli cells confers blood-testis barrier (BTB) function, but the regulator(s) and the mechanism(s) that modulate MT dynamics remains unexplored. Herein, we examined the role of CAMSAP2 (calmodulin-regulated spectrin-associated protein 2, a m
PMID 30994903

Japanese Journal

アクチン調節蛋白質をコードするヒトGsg3/CAPZ/3遺伝子の遺伝子多型

田中宏光,宮川康,辻村晃 [他],和田守正,Hiromitsu TANAKA,Yasushi MIYAGAWA,Akira TSUJIMURA,Morimasa WADA
長崎国際大学論叢 (14), 269-274, 2014
ｱｸﾁﾝｷｬｯﾋﾟﾝｸﾞ蛋白質 GSG3/CAPZA3 は､受精可能な精子の形態形成に重要な役割を担っている｡GSG3/CAPZA3 遺伝子は､ｲﾝﾄﾛﾝﾚｽ遺伝子として哺乳類に保存され､ﾏｳｽにおいてﾐｯｾﾝｽ変異が精子の減少と形態異常を誘導し､雄性不妊症の原因となることが知られている｡日本人において男性不妊症と GSG3/CAPZA3 遺伝子多型の関係を調べるため､261人の男性不妊症患者と1 …
NAID 120005578732

Gelsolin, an Actin Regulatory Protein, is Required for Differentiation of Mouse 3T3-L1 Cells into Adipocytes

Kawaji Atsuko,Ohnaka Yuki,Osada Shigehiro [他],Nishizuka Makoto,Imagawa Masayoshi
Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 33(5), 773-779, 2010
… (PPARγ) and CCAAT/enhancer-binding protein (C/EBP) α. …
NAID 130000248035