Streptococcus pneumoniae meningitis

肺炎球菌性髄膜炎

関

experimental pneumococcal meningitis、pneumococcal meningitis

WordNet

1. infectious disease characterized by inflammation of the meninges (the tissues that surround the brain or spinal cord) usually caused by a bacterial infection; symptoms include headache and stiff neck and fever and nausea
2. respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants
3. spherical Gram-positive bacteria occurring in pairs or chains; cause e.g. scarlet fever and tonsillitis (同)streptococci, strep

PrepTutorEJDIC

1. 脳膜炎
2. 肺炎
3. 連鎖球菌

UpToDate Contents

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• 1. 成人における特定病原体により引き起こされる細菌性髄膜炎の治療 treatment of bacterial meningitis caused by specific pathogens in adults
• 2. 小児における肺炎球菌性髄膜炎 pneumococcal meningitis in children
• 3. 成人における細菌性髄膜炎の初期治療および予後 initial therapy and prognosis of bacterial meningitis in adults
• 4. 侵襲性肺炎球菌（Streptococcus pneumoniae）感染症および菌血症 invasive pneumococcal streptococcus pneumoniae infections and bacteremia
• 5. 成人における急性細菌性髄膜炎の臨床的特徴および診断 clinical features and diagnosis of acute bacterial meningitis in adults

English Journal

• Intrathecal application of the antimicrobial peptide CRAMP reduced mortality and neuroinflammation in an experimental model of pneumococcal meningitis.

• Dörr A1, Kress E1, Podschun R2, Pufe T1, Tauber SC3, Brandenburg LO4.
• The Journal of infection.J Infect.2015 Aug;71(2):188-99. doi: 10.1016/j.jinf.2015.04.006. Epub 2015 Apr 17.
• Antimicrobial peptides (AP) are important components of the innate immune system. Our previous work revealed a higher mortality rate and up-regulation of proinflammatory gene expression as well as glial cell activation in cathelicidin-related antimicrobial peptide (CRAMP)-deficient mice after bacter
• PMID 25896094

• Epidemiology of bacterial meningitis in the North American Arctic, 2000-2010.

• Gounder PP1, Zulz T2, Desai S3, Stenz F4, Rudolph K2, Tsang R5, Tyrrell GJ6, Bruce MG2.
• The Journal of infection.J Infect.2015 Aug;71(2):179-87. doi: 10.1016/j.jinf.2015.04.001. Epub 2015 Apr 10.
• OBJECTIVE: To determine the incidence of meningitis caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in the North American Arctic during 2000-2010.METHODS: Surveillance data were obtained from the International Circumpolar Surveillance network. We defined a case
• PMID 25864638

• Myeloid-Related Protein 14 Promotes Inflammation and Injury in Meningitis.

• Wache C1, Klein M1, Ostergaard C2, Angele B1, Häcker H3, Pfister HW1, Pruenster M4, Sperandio M4, Leanderson T5, Roth J6, Vogl T6, Koedel U1.
• The Journal of infectious diseases.J Infect Dis.2015 Jul 15;212(2):247-57. doi: 10.1093/infdis/jiv028. Epub 2015 Jan 20.
• BACKGROUND: Neutrophilic inflammation often persists for days despite effective antibiotic treatment and contributes to brain damage in bacterial meningitis. We propose here that myeloid-related protein 14 (MRP14), an abundant cytosolic protein in myeloid cells, acts as an endogenous danger signal,
• PMID 25605866

Japanese Journal

• 症例報告 赤血球T抗原化による汎血球凝集反応を呈した肺炎球菌髄膜炎例

• 日本小児科学会雑誌 = The journal of the Japan Pediatric Society 119(6), 1012-1017, 2015-06
• NAID 40020512658

• 予後不良であった肺炎球菌性髄膜炎の1剖検例

• 東京女子医科大学雑誌 85(1), 16-21, 2015-02-25
• NAID 110009883331

• Streptococcus pneumoniaeによる細菌性髄膜炎を生じた蝶形骨洞炎例

• 日本耳鼻咽喉科感染症・エアロゾル学会会誌 = The journal of Japan Society for Infection and Aerosol in Otorhinolaryngology 3(2), 81-83, 2015
• NAID 40020490718

Related Links

• Pneumococcal Meningitis - Meningitis Research Foundation

Pneumococcal meningitis has the same symptoms as other forms of bacterial meningitis. Pneumococcal bacteria (Streptococcus pneumoniae) are the second biggest cause of bacterial meningitis in the UK and Ireland. ... The ...

• Streptococcus pneumoniae: Meningitis - MicrobeWiki

Symptoms Meningitis can be caused by an invasive pneumococcal infection of the brain and spine. There are many symptoms associated with this disease, and the bacterial meningitis caused by Streptococcus pneumoniae can ...

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★リンクテーブル★

リンク元	「肺炎球菌性髄膜炎」「experimental pneumococcal meningitis」
関連記事	「Streptococcus pneumoniae」「pneumoniae」

「肺炎球菌性髄膜炎」

　　[★]

英

pneumococcal meningitis、Streptococcus pneumoniae meningitis

関

肺炎球菌髄膜炎、実験的肺炎球菌髄膜炎

「experimental pneumococcal meningitis」

　　[★]

• 実験的肺炎球菌髄膜炎

関

pneumococcal meningitis、Streptococcus pneumoniae meningitis

「Streptococcus pneumoniae」

　　[★]

ラ

Streptococcus pneumoniae

同

肺炎球菌、肺炎レンサ球菌、肺炎連鎖球菌、肺炎双球菌、ストレプトコッカス・ニューモニエ

関

連鎖球菌

• first aid step1 2006 p.134,138

細菌学

• グラム陽性球菌
• 西洋槍(ランセット)型の双球菌
• α溶血性。ランスフィールド分類には分類されない
• オプトヒン感受性
• 自己融解 autolysis ←　培養しすぎに注意
• 中心部の陥凹した集落
• 莢膜多糖体を有する　←　抗食菌作用(C3bの付着に抵抗する)
• IgA proteaseを分泌
• 健常人の5-250%の気道に存在するが莢膜がない弱毒の株

感染症

• 肺炎球菌感染症

• 肺炎(大葉性肺炎)

• 慢性気道感染症の急性増悪

• 中耳炎、心内膜炎、関節炎、腹膜炎、軟部組織の炎症(SMB.248)
• 髄膜炎(化膿性髄膜炎)
• 敗血症：sickle cell anemia, splenectomy

易感染性宿主

• 2歳以下の乳幼児や老人で重症化しやすい
• 脾臓を受けた患者、急性骨髄性白血病、骨髄移植、HIV感染症で発症しやすい

most common cause of:

MOPS are Most OPtochin Sensitive

• meningitis 髄膜炎
• otitis media 中耳炎
• pneumonia 肺炎
• sinusitis 副鼻腔炎

診断

• 臨床像から疑い、胸部X線、喀痰のグラム染色、尿中抗原を行う。グラム染色と尿中抗原が陽性であれば特異的な治療を開始する。 (IRE.1010)
• (経験的治療の前に？)診断及び感受性検査のために喀痰培養、血液培養検査を行う。

参考

• 光顕像

• http://www.fujita-hu.ac.jp/~kimigaai/byouri/syourei/syourei21.htm
• http://www.kamimutsukawa.com/vaccine.html
• http://fp-the-ambiguous.blogspot.com/2008/02/blog-post.html

USMLE

• Q book p.192 29

「pneumoniae」

　　[★] Streptococcus pneumoniae、Klebsiella pneumoniae、Mycoplasma pneumoniae、Chlamydia pneumoniae、Chlamydophila pneumoniae