Lewy body

レビー小体

WordNet

1. invest with or as with a body; give body to (同)personify
2. the external structure of a vehicle; "the body of the car was badly rusted"
3. the main mass of a thing
4. a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
5. the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
6. a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
7. a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
8. an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
9. the central message of a communication; "the body of the message was short"

PrepTutorEJDIC

1. 〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
2. 《英話》人;(特に)男

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/15 20:31:33」(JST)

wiki en

[Wiki en表示]

Photomicrographs of regions of substantia nigra in this Parkinson's patient show Lewy bodies and Lewy neurites in various magnifications. Top panels show a 60-times magnification of the alpha-synuclein intraneuronal inclusions aggregated to form Lewy bodies. The bottom panels are 20x magnification images that show strand-like Lewy neurites and rounded Lewy bodies of various sizes. Neuromelanin-laden cells of the substantia nigra are visible in the background. Stains used: mouse monoclonal alpha-synuclein antibody; counterstained with Mayer's haematoxylin

Lewy bodies

Lewy bodies are abnormal aggregates of protein that develop inside nerve cells in Parkinson's disease (PD), Lewy body dementia and some other disorders. They are identified under the microscope when histology is performed on the brain.

Lewy bodies appear as spherical masses that displace other cell components. The two morphological types are classical (brain stem) Lewy bodies and cortical Lewy bodies. A classical Lewy body is an eosinophilic cytoplasmic inclusion consisting of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein. In contrast, a cortical Lewy body is less well defined and lacks the halo. Nonetheless, it is still made up of alpha-synuclein fibrils. Cortical Lewy bodies are a distinguishing feature of Dementia with Lewy bodies (DLB), but may occasionally be seen in ballooned neurons characteristic of Pick's disease and corticobasal degeneration, as well as in patients with other tauopathies. They are also seen in cases of multiple system atrophy, particularly the Parkinsonian variant.

History

Lewy bodies were discovered by Frederic Lewy in 1912.

Cell biology

Photomicrograph of the dorsal motor nucleus of the vagus nerve (DmX) in a transverse section along the upper medulla shown to be affected by the abnormally deposited alpha synuclein as part of intraneuronal Lewy bodies found (extreme right): DmX is one of the earliest sites affected by synuclein deposition in Parkinson's disease.

A Lewy body is composed of the protein alpha-synuclein associated with other proteins, such as ubiquitin, neurofilament protein, and alpha B crystallin. Tau proteins may also be present, and Lewy bodies may occasionally be surrounded by neurofibrillary tangles (NFTs). Lewy bodies and NFTs can occasionally exist in the same neuron, particularly in the amygdala.

Lewy bodies are believed to represent an aggresome response in the cell.

Lewy neurites

Similar to Lewy bodies, Lewy neurites are proteinaceous formations found in neurones of the diseased brain, comprising abnormal α-synuclein filaments and granular material. Like Lewy bodies, lewy neurites are a feature of α-synucleinopathies such as dementia with Lewy bodies, Parkinson's disease and multiple system atrophy (MSA). They are also found in the CA2-3 region of the hippocampus in Alzheimer's disease.

Cultural reference

Kelsey Grammer's lead character, mayor of Chicago Tom Kane in the television series Boss, suffers from early-stage dementia with Lewy bodies.

See also

• Neurite
• Proteopathy

References

External links

• Lewy Body Dementia Association

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. レビー小体型認知症の臨床的特徴および診断 clinical features and diagnosis of dementia with lewy bodies
• 2. レビー小体型認知症の予後および治療 prognosis and treatment of dementia with lewy bodies
• 3. レビー小体型認知症の疫学、病理学、および病因 epidemiology pathology and pathogenesis of dementia with lewy bodies
• 4. Cognitive impairment and dementia in Parkinson disease
• 5. 認知症治療におけるコリンエステラーゼ阻害剤 cholinesterase inhibitors in the treatment of dementia

English Journal

• Default network is not hypoactive in dementia with fluctuating cognition: an Alzheimer disease/dementia with Lewy bodies comparison.

• Franciotti R, Falasca NW, Bonanni L, Anzellotti F, Maruotti V, Comani S, Thomas A, Tartaro A, Taylor JP, Onofrj M.SourceDepartment of Neuroscience and Imaging, "G. d'Annunzio" University, Chieti, Italy; Aging Research Centre, Ce.S.I., "G. d'Annunzio" University Foundation, Chieti, Italy; ITAB, "G. d'Annunzio" University Foundation, Chieti, Italy.
• Neurobiology of aging.Neurobiol Aging.2013 Apr;34(4):1148-58. doi: 10.1016/j.neurobiolaging.2012.09.015. Epub 2012 Oct 11.
• Default mode network resting state activity in posterior cingulate cortex is abnormally reduced in Alzheimer disease (AD) patients. Fluctuating cognition and electroencephalogram abnormalities are established core and supportive elements respectively for the diagnosis of dementia with Lewy bodies (D
• PMID 23063646

• Screening for C9orf72 repeat expansions in parkinsonian syndromes.

• Yeh TH, Lai SC, Weng YH, Kuo HC, Wu-Chou YH, Huang CL, Chen RS, Chang HC, Traynor B, Lu CS.SourceSection of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan.
• Neurobiology of aging.Neurobiol Aging.2013 Apr;34(4):1311.e3-4. doi: 10.1016/j.neurobiolaging.2012.09.002. Epub 2012 Oct 11.
• Parkinsonism might precede, coincide, or follow the behavioral or language-predominant cognitive impairments characteristic of frontotemporal dementia (FTD). In this study, we analyze the hexanucleotide repeat expansions within C9orf72 gene in various parkinsonian syndromes because it is a recently
• PMID 23063644

• MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies.

• Colom-Cadena M, Gelpi E, Martí MJ, Charif S, Dols-Icardo O, Blesa R, Clarimón J, Lleó A.SourceNeurology Department, Institut d'Investigacions Biomediques Sant Pau, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
• Neurobiology of aging.Neurobiol Aging.2013 Mar;34(3):936-42. doi: 10.1016/j.neurobiolaging.2012.06.015. Epub 2012 Jul 21.
• The microtubule-associated protein tau (MAPT) H1 haplotype has been identified as a genetic risk factor for synucleinopathies. However, whether it modulates tau or α-synuclein pathology remains unknown. Our aim was to investigate the relationship between MAPT haplotypes and pathologic aggregates of
• PMID 22819391

Japanese Journal

• Pure psychiatric presentation of the Lewy body disease is depression: An analysis of 60 cases verified with myocardial meta-iodobenzylguanidine study

• Kobayashi Katsuji,Nakano Hiroyuki,Akiyama Noriko,Maeda Takashi,Yamamori Sanae
• International Journal of Geriatric Psychiatry 30(6), 663-668, 2015-06-01
• … Objective Parkinson's disease (PD), Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) were collectively termed Lewy body disease (LBD). …
• NAID 120005617944

• 教育講演 認知症と睡眠障害 (第19回認知神経科学会(その2))

• 井上 雄一
• 認知神経科学 17(1), 26-31, 2015-04
• NAID 40020513028

• レム睡眠行動異常症と神経変性疾患 (第19回認知神経科学会(その2)) -- (シンポジウム 認知神経科学の夜)

• 鈴木 圭輔,宮本 雅之,平田 幸一 [他]
• 認知神経科学 17(1), 1-7, 2015-04
• NAID 40020512973

Related Links

• Lewy Body Society | The more who know, the fewer who suffer

The Lewybody Society (LBS) is a registered UK charity which sponsors research and awareness of Dementia with Lewy Bodies (DLB). LBS also proves information and support to families affected by by Lewy Body Dementia (LBD).

• Lewy Body Disease: MedlinePlus - National Library of ...

Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental functions severe enough to affect normal activities and relationships. Lewy body disease happens when ...

---

★リンクテーブル★

リンク元	「老人斑」「レビー小体」
拡張検索	「dementia with Lewy body」「Lewy body disease」「diffuse Lewy body disease」「Lewy body dementia」
関連記事	「body」

「老人斑」

　　[★]

英

senile plaque

同

好銀性斑 argyrophilic plaque、老人性色素斑？これは皮膚症状

同？

アミロイド斑 amyloid plaqueこれは皮膚症状？、神経突起斑 neuritic plaque

関

アルツハイマー病

		関連疾患	細胞	物質
レビー小体	Lewy body	パーキンソン病	神経細胞 　(黒質、青斑核、迷走神経背側核、 　　マイネルト基底核、交感神経節)	エオシン好性硝子様封入体
老人斑	senile plaque	アルツハイマー病	-	βアミロイド
ブニナ小体	Bunina body	筋萎縮性側索硬化症	前角神経細胞	抗酸性の封入体
ピック小体	Pick body	ピック病	側頭葉、海馬の錐体細胞	ユビキチン、タウ、リン酸化神経線維陽性
アミロイド小体	corpola amylacea	？	老人の脳、前立腺、肺など	エオシンに染まる、PAS染色陽性

「レビー小体」

　　[★]

英

Lewy body

同

Lewy小体、レヴィ小体

概念

• パーキンソン病に特徴的
• 神経細胞に出現するエオシン好性硝子様封入体

臨床関連

• パーキンソン病：障害部位およびレビー小体の出現部位：黒質緻密部、迷走神経背側運動核、交感神経心臓枝の節後線維、嗅球、青斑核、縫線核、マイネルト基底核、扁桃核。時にレビー小体が大脳皮質に出現。(HBN.938)
• レビー小体型認知症：大脳、脳幹に広範にレビー小体が出現。

参考

• 1. 写真

http://www.emedicinehealth.com/script/main/art.asp?articlekey=122562

• 2. 写真

http://files.mda06im.webnode.com/200000020-af233b01cc/lewy%20body.jpg

• 3. 写真

http://www.genome.gov/Images/press_photos/highres/10004-300.jpg

「dementia with Lewy body」

　　[★] レビー小体型認知症, DLB, Lewy body dementia

「Lewy body disease」

　　[★] レビー小体病、レビー小体型認知症

「diffuse Lewy body disease」

　　[★] びまん性レビー小体病

「Lewy body dementia」

　　[★] レビー小体型認知症

「body」

　　[★]

• n.

• 体、本体、身体、ボディー