WordNet

a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
United States physician who first described the XXY-syndrome (born in 1912) (同)Harry F. Klinefelter, Harry Fitch Kleinfelter

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(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/20 04:01:10」(JST)

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Klinefelter syndrome or Klinefelter's syndrome (KS) (/ˈklaɪnfɛltər/) also known as 47,XXY or XXY, is the set of symptoms that result from two or more X chromosomes in males.^[1] The primary feature is sterility.^[1] Often symptoms may be subtle and many people do not realize they are affected. Sometimes symptoms are more prominent and may include weaker muscles, greater height, poor coordination, less body hair, smaller genitals, breast growth, and less interest in sex.^[2] Often it is only at puberty that these symptoms are noticed.^[3] Intelligence is usually normal; however, reading difficulties and problems with speech are more common. Symptoms are typically more severe if three or more X chromosomes are present.^[2]

Klinefelter syndrome usually occurs randomly. An older mother might increase the risk slightly. The condition is not inherited from one's parents.^[4] The underlying mechanisms involves at least one extra X chromosome in addition to a Y chromosome such that there is a total of 47 or more chromosomes rather than usual 46.^[5] KS is diagnosed by the genetic test known as a karyotype.^[3]

While there is no cure, a number of treatments may help.^[6] Physical therapy, speech and language therapy, counselling, and adjustments of teaching methods may be useful. Testosterone replacement may be used in those who have significantly low levels. Enlarged breasts may be removed by surgery. About half of males affected with the help of assisted reproductive technology have a chance of having children; however, this is expensive and carries risks.^[7] The condition has a nearly normal life expectancy.^[6]

Klinefelter syndrome is one of the most common chromosomal disorders, occurring in 1:500 to 1:1000 live male births.^[4]^[8] It is named after Harry Klinefelter who identified the condition in the 1940s.^[9] 1956 saw the identification of the extra X chromosome.^[10] Mice can also have the XXY syndrome, making them a useful research model.^[11]

Signs and symptoms

A person with typical untreated (surgery/hormones) Klinefelter 46,XY/47,XXY mosaic, diagnosed at age 19. Scar from biopsy may be visible on left nipple.

While it is possible to characterise XXY males based on physical characteristics, substantial variation in physical and developmental traits mean the only reliable method of positive or negative identification is karyotype testing.

Physical

As babies and children, XXY males may have weaker muscles and reduced strength. As they grow older, they tend to become taller than average. They may have less muscle control and coordination than other boys of their age.^[12]

During puberty, the physical traits of the syndrome become more evident; because these boys do not produce as much testosterone as other boys, they have a less muscular body, less facial and body hair, and broader hips. As teens, XXY males may develop breast tissue^[13] and also have weaker bones, and a lower energy level than other males.^[12]

By adulthood, XXY males look similar to males without the condition, although they are often taller. In adults, possible characteristics vary widely and include little to no sign of affectedness, a lanky, youthful build and facial appearance, or a rounded body type with some degree of gynecomastia (increased breast tissue).^[14] Gynecomastia is present to some extent in about a third of affected individuals, a slightly higher percentage than in the XY population. About 10% of XXY males have gynecomastia noticeable enough that they may choose to have cosmetic surgery.^[15]

Affected males are often infertile, or may have reduced fertility. Advanced reproductive assistance is sometimes possible.^[16]

The term hypogonadism in XXY symptoms is often misinterpreted to mean "small testicles" when it means decreased testicular hormone/endocrine function. Because of this (primary) hypogonadism, individuals will often have a low serum testosterone level but high serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.^[17] Despite this misunderstanding of the term, however, it is true that XXY men may also have microorchidism (i.e., small testicles).^[17]

XXY males are also more likely than other men to have certain health problems that typically affect females, such as autoimmune disorders, breast cancer, venous thromboembolic disease, and osteoporosis.^[12]^[18] In contrast to these potentially increased risks, it is currently thought that rare X-linked recessive conditions occur less frequently in XXY males than in normal XY males, since these conditions are transmitted by genes on the X chromosome, and people with two X chromosomes are typically only carriers rather than affected by these X-linked recessive conditions.^{[citation needed]}

Cognitive and developmental

Some degree of language learning or reading impairment may be present,^[19] and neuropsychological testing often reveals deficits in executive functions, although these deficits can often be overcome through early intervention.^[20] There may also be delays in motor development which can be addressed through occupational therapy and physical therapy.^[21] XXY males may sit up, crawl, and walk later than other infants; they may also struggle in school, both academically and with sports.^[12]

Cause

Birth of a cell with karyotype XXY due to a non-disjunction event of one X chromosome from a Y chromosome during meiosis I in the male.

Birth of a cell with karyotype XXY due to a non-disjunction event of one X chromosome during meiosis II in the female.

The extra chromosome is retained because of a nondisjunction event during paternal or maternal meiosis I (gametogenesis). Nondisjunction occurs when homologous chromosomes, in this case the X and Y or two X sex chromosomes, fail to separate, producing a sperm with an X and a Y chromosome or an egg with two X chromosomes. Fertilizing a normal (X) egg with this sperm produces an XXY offspring (Klinefelter). Fertilizing a double X egg with a normal sperm also produces an XXY offspring (Klinefelter).

Another mechanism for retaining the extra chromosome is through a nondisjunction event during meiosis II in the egg. Nondisjunction will occur when sister chromatids on the sex chromosome, in this case an X and an X, fail to separate. (meiosis) An XX egg is produced which, when fertilized with a Y sperm, yields XXY offspring. This XXY chromosome arrangement is one of the most common genetic variations from the XY karyotype, occurring in about 1 in 500 live male births.^[12] See also Triple X syndrome.

In mammals with more than one X chromosome, the genes on all but one X chromosome are not expressed; this is known as X inactivation. This happens in XXY males as well as normal XX females.^[22] However, in XXY males, a few genes located in the pseudoautosomal regions of their X chromosomes, have corresponding genes on their Y chromosome and are capable of being expressed.^[23]

The first published report of a man with a 47,XXY karyotype was by Patricia Jacobs and John Strong at Western General Hospital in Edinburgh, Scotland in 1959.^[24] This karyotype was found in a 24-year-old man who had signs of Klinefelter syndrome. Jacobs described her discovery of this first reported human or mammalian chromosome aneuploidy in her 1981 William Allan Memorial Award address.^[25]

Variations

48,XXYY and 48,XXXY occur in 1 in 18,000–50,000 male births. The incidence of 49,XXXXY is 1 in 85,000 to 100,000 male births.^[26] These variations are extremely rare. Additional chromosomal material can contribute to cardiac, neurological, orthopedic and other anomalies.

Males with Klinefelter syndrome may have a mosaic 47,XXY/46,XY constitutional karyotype and varying degrees of spermatogenic failure. Mosaicism 47,XXY/46,XX with clinical features suggestive of Klinefelter syndrome is very rare. Thus far, only about 10 cases have been described in literature.^[27]

Analogous XXY syndromes are known to occur in cats—specifically, the presence of calico or tortoiseshell markings in male cats is an indicator of the relevant abnormal karyotype. As such, male cats with calico or tortoiseshell markings are a model organism for Klinefelter syndrome.^[28]

Diagnosis

Percentages of Klinefelter's diagnosis divided by age groups, with most diagnoses occurring in adulthood.^[29]

About 10% of Klinefelter cases are found by prenatal diagnosis.^[30] The first clinical features may appear in early childhood or, more frequently, during puberty, such as lack of secondary sexual characters and aspermatogenesis,^[31] while tall stature as a symptom can be hard to diagnose during puberty. Despite the presence of small testes, only a quarter of the affected males are recognized as having Klinefelter syndrome at puberty.^[32]^[33] Another quarter receive their diagnosis in late adulthood. About 64% of affected individuals are never recognized.^[34] Often the diagnosis is made accidentally as a result of examinations and medical visits for reasons not linked to the condition.^[35]

The standard diagnostic method is the analysis of the chromosomes' karyotype on lymphocytes. In the past, the observation of the Barr body was common practice as well.^[33] To confirm mosaicism, it is also possible to analyze the karyotype using dermal fibroblasts or testicular tissue.^[36]

Other methods may be: research of high serum levels of gonadotropins (follicle-stimulating hormone and luteinizing hormone), presence of azoospermia, determination of the sex chromatin,^[37] and prenatally via chorionic villus sampling or amniocentesis. A 2002 literature review of elective abortion rates found that approximately 58% of pregnancies in the United States with a diagnosis of Klinefelter syndrome were terminated.^[38]

Differential diagnosis

The symptoms of Klinefelter syndrome are often variable; therefore, a karyotype analysis should be ordered when small testes, infertility, gynecomastia, long legs/arms, developmental delay, speech/language deficits, learning disabilities/academic issues and/or behavioral issues are present in an individual.^[5] The differential diagnosis for the Klinefelter syndrome can include the following conditions: fragile X syndrome, Kallmann syndrome and Marfan syndrome. The cause of hypogonadism can be attributed to many other different medical conditions.

There have been some reports of individuals with Klinefelter syndrome who also have other chromosome abnormalities, such as Down syndrome.^[39]

Treatment

The genetic variation is irreversible, however, individuals who want to look more masculine can take testosterone.^[40] Treating adolescents with implants of controlled release testosterone has shown good results when appropriately monitored.^[41] Hormone therapy is also useful in preventing the onset of osteoporosis.

Often individuals that have noticeable breast tissue or hypogonadism experience depression and/or social anxiety because they are outside of social norms. An academic term for this is psychosocial morbidity.^[42] At least one study indicates that planned and timed support should be provided for young men with Klinefelter syndrome to ameliorate current poor psychosocial outcomes.^[42] The surgical removal of the breasts may be considered for both the psychological reasons and to reduce the risk of breast cancer.^[43]

The use of behavioral therapy can mitigate any language disorders, difficulties at school and socialization. An approach by occupational therapy is useful in children with Down syndrome who have dyspraxia motor.^[44]

Infertility treatment

Intracytoplasmic sperm injection.

By 2010 over 100 successful pregnancies have been reported using IVF technology with surgically removed sperm material from males with Klinefelter syndrome.^[45] Microdissection testicular sperm extraction in adult men with Klinefelter syndrome reported success rates of up to 45%.^[46]

Prognosis

Children with XXY differ little from other children. Although they can face problems during adolescence, often emotional and behavioral, and difficulties at school, most of them can achieve full independence from their families in adulthood. Most can lead a normal, healthy life.

The results of a study carried out on 87 Australian adults with the syndrome shows that those who have had a diagnosis and appropriate treatment from a very young age had a significant benefit with respect to those who had been diagnosed in adulthood.^[47]

There is research suggesting Klinefelter syndrome substantially decreases life expectancy among affected individuals, though the evidence is not definitive.^[48] A 1985 publication identified a greater mortality mainly due to diseases of the aortic valve, development of tumors and possible subarachnoid hemorrhages, reducing life expectancy by about 5 years.^[49] Later studies have reduced this estimated reduction to an average of 2.1 years.^[50] These results are still questioned data, are not absolute, and will need further testing.^[48]

Epidemiology

This syndrome, evenly spread in all ethnic groups, has a prevalence of 1-2 subjects every 1000 males in the general population.^[32]^[51]^[52]^[53] 3.1% of infertile males have Klinefelter syndrome. The syndrome is also the main cause of male hypogonadism.^[54]

According to a meta-analysis, the prevalence of the syndrome has increased over the past decades; however, this does not appear to be correlated with the increase of the age of the mother at conception, as no increase was observed in the prevalence of other trisomies of sex chromosomes (XXX and XYY).^[55]

History

The syndrome was named after Harry Klinefelter, who, in 1942, worked with Fuller Albright at Massachusetts General Hospital in Boston, Massachusetts, and first described it in the same year.^[14]^[31] The account given by Klinefelter came to be known as Klinefelter syndrome as his name appeared first on the published paper, and seminiferous tubule dysgenesis was no longer used.

References

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^ ^a ^b "What are common symptoms of Klinefelter syndrome (KS)?". Eunice Kennedy Shriver National Institute of Child Health and Human Development. 2013-10-25. Retrieved 15 March 2015.
^ ^a ^b "How do health care providers diagnose Klinefelter syndrome (KS)?". Eunice Kennedy Shriver National Institute of Child Health and Human Development. 2012-11-30. Retrieved 15 March 2015.
^ ^a ^b "How many people are affected by or at risk for Klinefelter syndrome (KS)?". Eunice Kennedy Shriver National Institute of Child Health and Human Development. 2012-11-30. Retrieved 15 March 2015.
^ ^a ^b Visootsak J, Graham JM; Graham Jr (2006). "Klinefelter syndrome and other sex chromosomal aneuploidies". Orphanet Journal of Rare Diseases 1: 42. doi:10.1186/1750-1172-1-42. PMC 1634840. PMID 17062147.
^ ^a ^b "Is there a cure for Klinefelter syndrome (KS)?". Eunice Kennedy Shriver National Institute of Child Health and Human Development. 2012-11-30. Retrieved 16 March 2015.
^ "What are the treatments for symptoms in Klinefelter syndrome (KS)?". Eunice Kennedy Shriver National Institute of Child Health and Human Development. 2013-10-25. Retrieved 15 March 2015.
^ "Klinefelter syndrome". Genetics Home Reference. National Library of Medicine. 2012-10-30. Retrieved 2012-11-02.
^ "Klinefelter Syndrome (KS): Condition Information". nichd.nih.gov. 2013-11-15. Retrieved 15 March 2015.
^ Odom, Samuel L. (2009). Handbook of developmental disabilities (Pbk. ed.). New York: Guilford. p. 113. ISBN 9781606232484.
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^ Abramsky L, Chapple J (April 1997). "47,XXY (Klinefelter syndrome) and 47,XYY: estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling". Prenat Diagn 17 (4): 363–8. doi:10.1002/(SICI)1097-0223(199704)17:4<363::AID-PD79>3.0.CO;2-O. PMID 9160389.
^ ^a ^b Klinefelter HF Jr, Reifenstein EC Jr, Albright F. (1942). "Syndrome characterized by gynecomastia, aspermatogenesis without a-Leydigism and increased excretion of follicle-stimulating hormone". J Clin Endocrinol Metab 2 (11): 615–624. doi:10.1210/jcem-2-11-615.
^ ^a ^b Bojesen A, Juul S, Gravholt CH; Juul; Gravholt (Feb 2003). "Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study". Clin Endocrinol Metab 88 (2): 622–6. doi:10.1210/jc.2002-021491. PMID 12574191.
^ ^a ^b Kamischke A, Baumgardt A, Horst J, Nieschlag E; Baumgardt; Horst; Nieschlag (Jan–Feb 2003). "Clinical and diagnostic features of patients with suspected Klinefelter syndrome". J Androl 24 (1): 41–8. PMID 12514081.
^ Smyth CM, Bremner WJ; Bremner (22 June 1998). "Klinefelter syndrome". Arch Intern Med 158 (12): 1309–14. doi:10.1001/archinte.158.12.1309. PMID 9645824.
^ Grzywa-Celińska A, Rymarz E, Mosiewicz J; Rymarz; Mosiewicz (October 2009). "[Diagnosis differential of Klinefelter's syndrome in a 24-year old male hospitalized with sudden dyspnoea--case report]". Pol. Merkur. Lekarski (in Polish) 27 (160): 331–3. PMID 19928664.
^ Kurková S, Zemanová Z, Hána V, Mayerová K, Pacovská K, Musilová J, Stĕpán J, Michalová K; Zemanová; Hána; Mayerová; Pacovská; Musilová; Stĕpán; Michalová (April 1999). "[Molecular cytogenetic diagnosis of Klinefelter's syndrome in men more frequently detects sex chromosome mosaicism than classical cytogenetic methods]". Cas. Lek. Cesk. (in Czech) 138 (8): 235–8. PMID 10510542.
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^ Mansfield C, Hopfer S, Marteau TM; Hopfer; Marteau (1999). "Termination rates after prenatal diagnosis of Down syndrome, spina bifida, anencephaly, and Turner and Klinefelter syndromes: A systematic literature review". Prenatal Diagnosis 19 (9): 808–812. doi:10.1002/(SICI)1097-0223(199909)19:9<808::AID-PD637>3.0.CO;2-B. PMID 10521836.
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^ ^a ^b Simm PJ, Zacharin MR; Zacharin (April 2006). "The psychosocial impact of Klinefelter syndrome--a 10 year review". J. Pediatr. Endocrinol. Metab. 19 (4): 499–505. PMID 16759035.
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^ Harold Chen. "Klinefelter Syndrome - Treatment". medscape.com. Retrieved 4 September 2012.
^ Fullerton G, Hamilton M, Maheshwari A; Hamilton; Maheshwari (2010). "Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009?". Hum Reprod. 25 (3): 588–97. doi:10.1093/humrep/dep431. PMID 20085911.
^ Ramasamy, R; Ricci, JA; Palermo, GD; Gosden, LV; Rosenwaks, Z; Schlegel, PN (September 2009). "Successful fertility treatment for Klinefelter's syndrome.". The Journal of Urology 182 (3): 1108–13. doi:10.1016/j.juro.2009.05.019. PMID 19616796.
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^ Price WH, Clayton JF, Wilson J, Collyer S, De Mey R; Clayton; Wilson; Collyer; De Mey (December 1985). "Causes of death in X chromatin positive males (Klinefelter's syndrome)". J Eppmidemiol Community Health 39 (4): 330–6. doi:10.1136/jech.39.4.330. PMC 1052467. PMID 4086964.
^ Bojesen A, Juul S, Birkebaek N, Gravholt CH; Juul; Birkebaek; Gravholt (August 2004). "Increased mortality in Klinefelter syndrome". J. Clin. Endocrinol. Metab. 89 (8): 3830–4. doi:10.1210/jc.2004-0777. PMID 15292313.
^ Jacobs PA (1979). "Recurrence risks for chromosome abnormalities". Birth Defects Orig Artic Ser 15 (5C): 71–80. PMID 526617.
^ MACLEAN N, HARNDEN DG, COURT BROWN WM; Harnden; Court Brown (Aug 1961). "Abnormalities of sex chromosome constitution in newborn babies". Lancet 2 (7199): 406–8. doi:10.1016/S0140-6736(61)92486-2. PMID 13764957.
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^ Morris JK, Alberman E, Scott C, Jacobs P; Alberman; Scott; Jacobs (Feb 2008). "Is the prevalence of Klinefelter syndrome increasing?". Eur J Hum Genet 16 (2): 163–70. doi:10.1038/sj.ejhg.5201956. PMID 18000523.

External links

Klinefelter syndrome at DMOZ

UpToDate Contents

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1. 男性における原発性性腺機能低下の原因 causes of primary hypogonadism in males
2. 性染色体異常 sex chromosome abnormalities
3. 性腺機能低下を呈する男性の臨床的特徴および診断 clinical features and diagnosis of male hypogonadism
4. 高身長や異常に急激な成長がみられる小児 the child with tall stature and or abnormally rapid growth
5. 男性不妊症の治療 treatment of male infertility

English Journal

Only a minority of sex chromosome abnormalities are detected by a national prenatal screening program for Down syndrome.

Viuff MH1, Stochholm K1, Uldbjerg N2, Nielsen BB2; Danish Fetal Medicine Study Group, Gravholt CH3.
Human reproduction (Oxford, England).Hum Reprod.2015 Aug 6. pii: dev192. [Epub ahead of print]
STUDY QUESTION: How does a national prenatal screening program for Down syndrome (DS) perform in detecting sex chromosome abnormalities (SCAs)-Turner syndrome (TS), Klinefelter syndrome, 47,XXX and 47,XYY syndromes.SUMMARY ANSWER: The SCA detection rate resulting from DS screening was below 50% for
PMID 26251461

Testicular sperm sampling by subcapsular orchiectomy in Klinefelter patients: A new simplified treatment approach.

Fedder J1, Gravholt CH2, Kristensen SG3, Marcussen N4, Engvad B4, Mains A5, Andersen CY3.
Urology.Urology.2015 Aug 4. pii: S0090-4295(15)00664-0. doi: 10.1016/j.urology.2015.06.044. [Epub ahead of print]
OBJECTIVES: To evaluate subcapsular orchiectomy as a method to retrieve spermatozoa from minute testicular foci in men with Klinefelter's syndrome (KS).METHODS: Fourteen men with KS were consecutively recruited to unilateral subcapsular orchiectomy. Testicular tissue was dissected mechanically and e
PMID 26254174

Neural systems for social cognition: gray matter volume abnormalities in boys at high genetic risk of autism symptoms, and a comparison with idiopathic autism spectrum disorder.

Goddard MN1, Swaab H, Rombouts SA, van Rijn S.
European archives of psychiatry and clinical neuroscience.Eur Arch Psychiatry Clin Neurosci.2015 Aug 2. [Epub ahead of print]
Klinefelter syndrome (47, XXY) is associated with several physical, cognitive, and behavioral consequences. In terms of social development, there is an increased risk of autism symptomatology. However, it remains unclear how social deficits are related to abnormal brain development and to what degre
PMID 26233431

Japanese Journal

クラインフェルター症候群患者における性機能とホルモン値との関連性についての検討

重原一慶,高栄哲,飯島将司,杉本和宏,福島正人,前田雄司,並木幹夫,重原一慶,島村正喜
日本性機能学会雑誌 = The japanese journal of Impotence Research 27(1), 7-13, 2012-06-30
NAID 10030809188

Clinical and social characteristics of Korean men with Klinefelter syndrome

BAK Chong Won,BYUN Jae Sang,LEE Jee Han,PARK Ji Hye,LEE Kyung-Ah,SHIM Sung Han
International journal of urology 19(5), 443-449, 2012-05-01
NAID 10030754897

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★リンクテーブル★

リンク元	「クラインフェルター症候群」「女性化乳房」
関連記事	「syndrome」

「クラインフェルター症候群」

Klinefelter syndrome
	47,XXY karyotype
Classification and external resources
Synonyms	XXY syndrome
Specialty	medical genetics
ICD-10	Q98.0-Q98.4
ICD-9-CM	758.7
DiseasesDB	7189
MedlinePlus	000382
eMedicine	ped/1252
Patient UK	Klinefelter syndrome
MeSH	D007713
	[edit on Wikidata]

　　[★]

英: Klinefelter's syndrome, KS, Klinefelter syndrome
同: Klinefelter症候群, XXY症候群 XXY syndrome

概念

X染色体過剰に由来する性染色体異常症候群
男性性腺機能不全のうち最も多い疾患である。　　男性不妊を主訴とした染色体異常の中で最も多く600-1000人中1人に見つかるとされる。

Y染色体があれば外性器は男性化する

病因

染色体異常

核型：47,XXY(約80%), 48,XXXY, 49,XXXXY, 46,XY/47,XXYモザイク、48,XXYYなど
受精卵の卵割時のX染色体の不分離。
性腺は精巣へ分化し、内性器・外性器は正常に分化するが、精巣機能が正常に作用しない

疫学

発生頻度：男子の1/1,000(男児600出生に1人とも)

症状

無精子症、小睾丸、女性化乳房、高身長、細長い体型、薄い髭・体毛
知能は通常正常。
女性化乳房を呈する症例で男性乳ガンの発生率が高いらしい？

検査

血液検査

テストステロン産生不全、ゴナドトロピン高値(LH・FSH高値。精巣の機能が異常ということか？)　→　二次性徴の欠如、不妊

染色体検査

47,XXY

診断

確定診断：染色体分析

国試

101G050

「女性化乳房」

　　[★]

gyneco mastia
英: gynecomastia
同: 女性化乳房症

病因 (HIM.2318)

1. アンドロゲンの不足→↑estrogen/androgen ratio→女性化乳房

クラインフェルター症候群 Klinefelter syndrome

2. アンドロゲンの不応症？(angrogen insensitivity disorgers
3. エストロゲンの過剰産生

including Sertoli cell tumors in isolation or in association with Peutz-Jegher syndrome or Carney complex
tumors that produce hCG, including some testicular tumors, stimulate Leydig cell estrogen synthesis.

4. アロマターゼの基質の増加：アンドロステンジオンの増加

CAH, 甲状腺機能亢進症、most feminizing adrenal tumors
liver diseaseによるアンドロステンジオンの異化の低下

5. アロマターゼ活性の亢進：肥満

肥満
肝臓や副腎の腫瘍

6. (まれ)遺伝
7. 薬剤：ジギタリス、スピロノラクトン、エストロゲン、アンドロゲン

生理的女性化乳房

SPE.11 QB.O-27 101B080

男性でも13-14歳際頃に乳腺の肥大、乳房の腫大、腫大部の疼痛を認める

「syndrome」

　　[★]

n.

症候群

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匿名

検索

案内

Klinefelter syndrome