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1. 抗核抗体染色パターンおよび関連自己抗体の臨床的意義clinical significance of antinuclear antibody staining patterns and associated autoantibodies [show details]
… cell nuclear antigen (PCNA) pattern produce nuclear speckled staining during the G1 phase of the cell cycle, when cells are increasing in size. During S phase, when DNA replication occurs, there is dense homogeneous …
2. ミトコンドリアの構造、機能、および遺伝学mitochondrial structure function and genetics [show details]
… amount of mutant DNA in a cell and surpass its threshold. The clinical phenotype can then change in a previously unaffected tissue. Mitochondrial DNA replication is not linked to… mitochondrial DNA, nuclear DNA mutations affecting the mitochondria follow Mendelian genetics and are inherited in an autosomal dominant, autosomal recessive, or X-linked pattern .…
3. HIV薬剤耐性検査結果の解釈についてinterpretation of hiv drug resistance testing [show details]
…incapable of replication. However, some mutations can persist in proviral HIV DNA in resting memory cells if the mutant virus has a selective growth advantage over wild-type virus . If viral replication is not… "pathways": Pattern 1 includes the M41L, L210W, and T215Y mutations. Pattern 2 involves the D67N, K70R, and K219Q/E/N mutations . However, there can be mixtures of both patterns present in some…
4. 次世代DNAシークエンシング（NGS）：原理および臨床応用next generation dna sequencing ngs principles and clinical applications [show details]
… material DNA must be amplified prior to NGS in order to run the sequencing reactions. Amplification involves exponential in vitro replication of patient DNA using PCR-based methods. While the DNA polymerase …
5. 2本鎖（ds）DNA、Sm、およびU1 RNPに対する抗体antibodies to double stranded ds dna sm and u1 rnp [show details]
… deoxyribonucleic acid (DNA) can be primarily divided into two groups: those reactive with denatured, single-stranded (ss)DNA and those recognizing native, double-stranded (ds)DNA.… when a given patient follows the characteristic pattern of rising anti-dsDNA antibodies and falling complement in the setting of a flare.…

English Journal

Effects of cadmium toxicity on diploid wheat (Triticum urartu) and the molecular mechanism of the cadmium response.

Qiao K, Liang S, Wang F, Wang H, Hu Z, Chai T.
Journal of hazardous materials. 2019 Jul;374()1-10.
Cadmium (Cd) is a widespread soil contaminant that readily accumulates in wheat, and posing a potential threat to human health. Our aim is to investigate Cd toxicity effect and molecular mechanisms for wheat. In this study, the physiological indexes, morphology, and gene expression patterns of diplo
PMID 30974226

Essential role of inverted repeat in Epstein-Barr virus IR-1 in B cell transformation; geographical variation of the viral genome.

Bridges R, Correia S, Wegner F, Venturini C, Palser A, White RE, Kellam P, Breuer J, Farrell PJ.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2019 May;374(1773)20180299.
Many regions of the Epstein-Barr virus (EBV) genome, repeated and unique sequences, contribute to the geographical variation observed between strains. Here we use a large alignment of curated EBV genome sequences to identify major sites of variation in the genome of type 1 EBV strains; the CAO delet
PMID 30955492

Temporal progression of gene regulation of peripheral white blood cells explains gender dimorphism of critically ill patients after trauma.

Kolte A, König R.
Molecular medicine (Cambridge, Mass.). 2019 May;25(1)19.
The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their peripheral immune cells. We investigated the progression of the transcription profiles of peri
PMID 31096912

Japanese Journal

DNA methylation inhibitor causes cell growth retardation and gene expression changes in feline lymphoma cells

FUJITA Maika,KANEDA Masahiro
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 79(8), 1352-1358, 2017
… <p>DNA methylation is an epigenetic mechanism controlling gene expression without affecting DNA sequences, and aberrant DNA methylation patterns are features of a number of diseases. …
NAID 130005901414

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

Dillon Laura W.,Kumar Pankaj,Shibata Yoshiyuki,Wang Yuh Hwa,Willcox Smaranda,Griffith Jack D.,Pommier Yves,Takeda Shunichi,Dutta Anindya
Cell Reports 11(11), 1749-1759, 2015-06-23
… Analysis of microDNAs from a set of human cancer cell lines revealed lineage-specific patterns of microDNA origins. … A survey of microDNAs from chicken cells defective in various DNA repair proteins reveals that homologous recombination and non-homologous end joining repair pathways are not required for microDNA production. … Deletion of the MSH3 DNA mismatch repair protein results in a significant decrease in microDNA abundance, specifically from non-CpG genomic regions. …
NAID 120005829370

Genetic similarity of circulating and small intestinal virus at the end stage of acute pathogenic simian-human immunodeficiency virus infection.

Matsuyama-Murata Megumi,Inaba Katsuhisa,Horiuchi Reii,Fukazawa Yoshinori,Ibuki Kentaro,Hayami Masanori,Miura Tomoyuki
Frontiers in microbiology (4), 2013-07-22
… To identify the major virus replication site at the end stage of SHIV infection, we investigated the systemic tissues of SHIV-infected monkeys that developed AIDS-like disease. … We quantified proviral DNA, and compared the mutation patterns of the viruses in various systemic tissues and in peripheral blood through phylogenetic analysis of the full genome sequence. …
NAID 120005465604