WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency.

Bay JT1, Katzenstein TL2, Kofoed K3, Patel D1, Skjoedt MO1, Garred P4, Schejbel L1.
Clinical immunology (Orlando, Fla.).Clin Immunol.2015 Oct;160(2):315-8. doi: 10.1016/j.clim.2015.05.004. Epub 2015 May 16.
Factor I is an important regulator of the complement system. Lack of Factor I causes uncontrolled activation of the complement system leading to consumption of C3. Complete deficiency of Factor I is a rare condition and only around 40 cases has been reported in the literature. The clinical presentat
PMID 25988862

Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome.

Bernabéu-Herrero ME1, Jiménez-Alcázar M2, Anter J3, Pinto S3, Sánchez Chinchilla D3, Garrido S4, López-Trascasa M4, Rodríguez de Córdoba S3, Sánchez-Corral P5.
Molecular immunology.Mol Immunol.2015 Oct;67(2 Pt B):276-86. doi: 10.1016/j.molimm.2015.06.021. Epub 2015 Jul 7.
Atypical hemolytic uremic syndrome (aHUS) is a severe thrombotic microangiopathy affecting the renal microvasculature and is associated with complement dysregulation caused by mutations or autoantibodies. Disease penetrance and severity is modulated by inheritance of "risk" polymorphisms in the comp
PMID 26163426

Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine.

Granoff DM1, Costa I1, Konar M1, Giuntini S1, Van Rompay KK2, Beernink PT1.
The Journal of infectious diseases.J Infect Dis.2015 Sep 1;212(5):784-92. doi: 10.1093/infdis/jiv081. Epub 2015 Feb 12.
BACKGROUND: The meningococcal vaccine antigen, factor H (FH)-binding protein (FHbp), binds human complement FH. In human FH transgenic mice, binding decreased protective antibody responses.METHODS: To investigate the effect of primate FH binding, we immunized rhesus macaques with a 4-component serog
PMID 25676468

Mapping of the Sites Responsible for Factor I-Cofactor Activity for Cleavage of C3b and C4b on Human C4b-Binding Protein (C4bp) by Deletion Mutagenesis

Fukui Aya,Yuasa-Nakagawa Tomoko,Murakami Yusuke [他],FUNAMI Kenji,KISHI Natue,MATSUDA Tadashi,FUJITA Teizo,SEYA Tsukasa,NAGASAWAS Shigeharu
The journal of biochemistry 132(5), 719-728, 2002-11-01
NAID 80015751009

古典的経路：C3からC4b2aのもつC3 convatase活性により生成し、C4b2a3bはC5 convertase活性を持つ (2008前期免疫学プリント 68)
別経路：C3からC3bBbPのもつC3 convertase活性により生成し、n(C3bBb)はC5 convertase活性を持つ (2008前期免疫学プリント 68)
別経路では細菌の表面でC3bが安定的に存在→オプソニン作用を有する