機能

炎症のペプチドメディエーター(anaphylatoxin)
食細胞のリクルート(chemotaxis)

活性はC5aの約1/200 (SMB.35)

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

carbonの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/19 13:10:53」(JST)

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1. 補体経路 complement pathways
2. 補体系の制御因子および受容体 regulators and receptors of the complement system
3. 血液-血液透析膜の相互作用に関与する生化学的機序 biochemical mechanisms involved in blood hemodialysis membrane interactions
4. 免疫グロブリンの使用における一般原則 general principles in the use of immune globulin
5. 補体系の概要および臨床的評価 overview and clinical assessment of the complement system

English Journal

G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2.

Kashem SW, Subramanian H, Collington SJ, Magotti P, Lambris JD, Ali H.AbstractAlthough human mast cells express G protein coupled receptors for the anaphylatoxin C3a, previous studies indicated that C3a causes mast cell degranulation, at least in part, via a C3a receptor-independent mechanism similar to that proposed for polycationic molecules such as compound 48/80. The purpose of the present study was to delineate the receptor specificity of C3a-induced degranulation in human mast cells. We found that C3a, a C3a receptor "superagonist" (E7) and compound 48/80 induced Ca(2+) mobilization and degranulation in a differentiated human mast cell line, LAD2. However, C3a and E7 caused Ca(2+) mobilization in an immature mast cell line, HMC-1 but compound 48/80 did not. We have previously shown that LAD2 cells express MrgX1 and MrgX2 but HMC-1 cells do not. To delineate the receptor specificity for C3a and compound 48/80 further, we generated stable transfectants expressing MrgX1 and MrgX2 in a rodent mast cell line, RBL-2H3 cells. We found that compound 48/80 caused degranulation in RBL-2H3 cells expressing MrgX1 and MrgX2 but C3a did not. By contrast, E7 activated RBL-2H3 cells expressing MrgX2 but not MrgX1. These findings demonstrate that in contrast to previous reports, C3a and compound 48/80 do not use a shared mechanism for mast cell degranulation. It shows that while compound 48/80 utilizes MrgX1 and MrgX2 for mast cell degranulation C3a does not. It further reveals the novel finding that the previously characterized synthetic peptide, C3a receptor "superagonist" E7 activates human mast cells via two mechanisms; one involving the C3a receptor and the other MrgX2.
European journal of pharmacology.Eur J Pharmacol.2011 Oct 1;668(1-2):299-304. Epub 2011 Jul 3.
Although human mast cells express G protein coupled receptors for the anaphylatoxin C3a, previous studies indicated that C3a causes mast cell degranulation, at least in part, via a C3a receptor-independent mechanism similar to that proposed for polycationic molecules such as compound 48/80. The purp
PMID 21741965

Cellular glutathione in fatty liver in vitro models.

Garcia MC, Amankwa-Sakyi M, Flynn TJ.SourceFDA, Center for Food Safety and Applied Nutrition, Division of Toxicology, Laurel, MD 20708, United States.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2011 Oct;25(7):1501-6. Epub 2011 May 17.
The range of non-alcoholic fatty liver disease (NAFLD) includes simple hepatic steatosis, the inflammatory non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. The accumulation of specific lipids in hepatocytes has been associated with oxidative stress and progression of the disease. Elevat
PMID 21620948

Japanese Journal

被粉砕性の異なる石灰石微粉末を混和したC3A相高含有セメントの流動性

荻野正貴,新大軌,丸屋英二 [他]
セッコウ・石灰・セメント・地球環境の科学 18(351), 70-74, 2011-03
NAID 40018733585

Synthetic Studies on (+)-Biotin, Part 15: A Chiral Squaramide-Mediated Enantioselective Alcoholysis Approach toward the Total Synthesis of (+)-Biotin

Chen Xu-Xiang,Xiong Fei,Fu Han,Liu Zhi-Qian,Chen Fen-Er
CHEMICAL & PHARMACEUTICAL BULLETIN 59(4), 488-491, 2011
An efficient stereocontrolled total synthesis of (+)-biotin (1) has been achieved via the intermediacy of Roches lactone 5 starting from cis-1,3-dibenzyl-2-imidazole-4,5-dicarboxylic acid (2). The bif …
NAID 130000648970