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1. 分子遺伝学の原理principles of molecular genetics [show details]
… implicated as susceptibility factors for common, complex genetic traits . Prior to the process of translation (formation of specific proteins from an RNA template),… binding to other nucleic acid chains. Other functions include protection from exonucleases, initiation of translation through ribosomal binding, and mRNA translocation from nucleus to cytoplasm. A long tail …
2. ミトコンドリアの構造、機能、および遺伝学mitochondrial structure function and genetics [show details]
…(comprised of 48 and 29 proteins, respectively) Translation initiation, elongation and release factors; Ribosomal protein assembly factors; mRNA polyadenylation factors; Translational activators; The mitochondrial …
3. サラセミア症候群の分子遺伝学的特性molecular genetics of the thalassemia syndromes [show details]
… is translated into the intended sequence of amino acids. Messenger RNA translation is an extraordinarily complex process. The rate limiting step for translation of globin mRNAs is "initiation"; normal… Heme-regulated alpha-subunit of eukaryotic translational initiation factor 2 (eIF2alpha) kinase (HRI) prevents the accumulation…
4. C型肝炎ウイルス感染治療のための直接作用型抗ウイルス薬direct acting antivirals for the treatment of hepatitis c virus infection [show details]
… are inhibitors of the NS3/4A protease, the NS5A protein, and the NS5B polymerase. NS3/4A protease inhibitors are inhibitors of the NS3/4A serine protease,… the viral RNA is translated through host machinery into a polyprotein, which is cleaved during and after translation by both host and viral-encoded… Rare cases of symptomatic bradycardia have been reported following the initiation of sofosbuvir-containing regimens; most,…
5. von Willebrand因子の生物学および正常機能biology and normal function of von willebrand factor [show details]
… gene that encode domains A1, A2, and A3 . Von Willebrand factor is synthesized in endothelial cells and megakaryocytes as a primary translation product of 2813 amino acids; it subsequently undergoes considerable …