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1. 分子遺伝学の原理principles of molecular genetics [show details]
… these instances, the flow of genetic information is from RNA to DNA, then back to RNA prior to translation. The mitochondrial genetic code differs from the nuclear genetic code in that UGA encodes tryptophan …
2. サラセミア症候群の分子遺伝学的特性molecular genetics of the thalassemia syndromes [show details]
… the mRNA is translated into the intended sequence of amino acids. Messenger RNA translation is an extraordinarily complex process. The rate limiting step for translation of globin mRNAs is… relatively compact gene clusters, and their well characterized physiology, pathology, and clinical genetics, the globin genes were the first human genes to be cloned and thoroughly characterized. The mutations …
3. 成人の肺静脈閉塞症／肺毛細血管腫症の疫学、発症機序、臨床評価、診断epidemiology pathogenesis clinical evaluation and diagnosis of pulmonary veno occlusive disease pulmonary capillary hemangiomatosis in adults [show details]
…unknown and likely multifactorial. Genetic mutations in the eukaryotic translation initiation factor 2-alpha kinase (EIF2AK4) gene have been described in the familial form of PVOD. In addition, several …
4. 遺伝学：用語集genetics glossary of terms [show details]
… for genetic perturbation in research. Therapeutic applications for the correction of inherited genetic variation are under investigation. A GWAS (pronounced "gee-wass") study is a type of genetic mapping …
5. ゲノムワイド関連解析：原理および応用genetic association and gwas studies principles and applications [show details]
… not necessarily translate into a clinical useful marker because the allele frequency may be low. These considerations show the difficulty in translating a statistically significant genetic predictor into …

English Journal

miR-29b inhibits the progression of multiple myeloma through downregulating FOXP1.

Wang H, Ding Q, Wang M, Guo M, Zhao Q.
Hematology (Amsterdam, Netherlands). 2019 Dec;24(1)32-38.
Increasing evidence has suggested that miR-29b plays an antitumor effect in multiple malignancies via the regulation of cell proliferation, apoptosis, invasion and migration. In the present study, we aimed to explore the underlying function and mechanism of miR-29b in multiple myeloma (MM). The expr
PMID 30068241

Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2.

Chiu YL, Wu YY, Barndt RB, Yeo YH, Lin YW, Sytwo HP, Liu HC, Xu Y, Jia B, Wang JK, Johnson MD, Lin CY.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)692-702.
Matriptase is ectopically expressed in neoplastic B-cells, in which matriptase activity is enhanced by negligible expression of its endogenous inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. HAI-1, however, is also involved in matriptase synthesis and intracellular trafficking. The
PMID 30777474

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity.

Logozzi M, Capasso C, Di Raimo R, Del Prete S, Mizzoni D, Falchi M, Supuran CT, Fais S.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)272-278.
Acidity and hypoxia are crucial phenotypes of tumour microenvironment both contributing to the selection of malignant cells under a micro evolutionistic pressure. During the tumour progression, nanovesicles, called exosomes and the metalloenzyme carbonic anhydrase IX (CA IX) affect the tumour growth
PMID 30734594

Japanese Journal

RAS

Chandela Akash,Ueno Yoshihito
Reviews in Agricultural Science 7(0), 10-28, 2019
… <p>RNA interference (RNAi) has emerged as a critical tool for genetic therapeutics. … However, successful translation of these drug delivery systems for the clinical application has still been a great setback for these class of pharmaceutics. …
NAID 130007635113

日本循環器學誌

Taufiq Fikri,Tsuneto Motokazu,Shirayoshi Yasuaki,Ninomiya Haruaki,Saitoh Tatsuya,Nakai Akira,Yamamoto Kazuhiro,Hisatome Ichiro,Maharani Nani,Li Peili,Kurata Yasutaka,Ikeda Nobuhito,Kuwabara Masanari,Otani Naoyuki,Miake Junichiro,Hasegawa Akira
Circulation Journal 83(4), 718-726, 2019
… Uric acid enhanced phosphorylation of Akt and HSF1, and thereby increased both transcription and translation of Hsp70; …
NAID 130007620506

Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes

Taufiq Fikri,Tsuneto Motokazu,Shirayoshi Yasuaki,Ninomiya Haruaki,Saitoh Tatsuya,Nakai Akira,Yamamoto Kazuhiro,Hisatome Ichiro,Maharani Nani,Li Peili,Kurata Yasutaka,Ikeda Nobuhito,Kuwabara Masanari,Otani Naoyuki,Miake Junichiro,Hasegawa Akira
日本循環器學誌, 2019
… Uric acid enhanced phosphorylation of Akt and HSF1, and thereby increased both transcription and translation of Hsp70; …
NAID 130007602527