小胞アセチルコリン輸送体、小胞アセチルコリントランス・ーター

関: VAChT、vesicular acetylcholine transport protein

WordNet

move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
a long truck for carrying motor vehicles (同)car transporter
a crane for moving material with dispatch as in loading and unloading ships
a neurotransmitter that is a derivative of choline; released at the ends of nerve fibers in the somatic and parasympathetic nervous systems
of or relating to or involving vesicles; "normal vesicular breathing"

PrepTutorEJDIC

(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
自動車運搬用大型トラック
アセチルコリン(神経を刺激し筋肉運動を起こす化合物)
小嚢の小胞の,小嚢(小胞)状の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/15 22:59:37」(JST)

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[Wiki en表示]

The Vesicular acetylcholine transporter (VAChT) is a neurotransmitter transporter which is responsible for loading acetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion.^[1]^[2] It is encoded by Solute carrier family 18, member 3 (SLC18A3) gene. VAChT is able to transport ACh into vesicles by relying on an exchange between protons that were previously pumped into the vesicle diffusing out. ACh molecules are then carried into the cell by the action of exiting protons. ^[3] Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene.

VACh uptake inhibitors

Radiolabeled compounds

PET imaging of the VAChT may provide insights into early diagnosis of Alzheimer's disease.

(−)-trans-2-Hydroxy-3-(4-(4-[¹⁸F]fluorobenzoyl)piperidino)tetralin; racemate: Ki = 2.70 nM for VAChT, 191 nM for σ1, and 251 nM for σ2^[4]

References

^ Erickson JD, Varoqui H (2000). "Molecular analysis of vesicular amine transporter function and targeting to secretory organelles". FASEB J. 14 (15): 2450–8. doi:10.1096/fj.00-0206rev. PMID 11099462.
^ Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (1996). "Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3547–52. doi:10.1073/pnas.93.8.3547. PMC 39647. PMID 8622973.
^ Waymire, Jack. "Storage of ACh". University of Texas Medical Center.
^ Tu Z, Efange SM, Xu J et al. (February 2009). "Synthesis and in Vitro and in Vivo Evaluation of (18)F-Labeled Positron Emission Tomography (PET) Ligands for Imaging the Vesicular Acetylcholine Transporter". J. Med. Chem. 52 (5): 1358–69. doi:10.1021/jm8012344. PMC 2765529. PMID 19203271.

External links

Vesicular Acetylcholine Transporter at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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English Journal

Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig rectum and human colon.

Sharrad DF, de Vries E, Brookes SJ.SourceDepartment of Human Physiology and Centre for Neuroscience, Flinders Medical Science and Technology, School of Medicine, Flinders University, Bedford Park, South Australia, Australia.
The Journal of comparative neurology.J Comp Neurol.2013 Feb 15;521(3):657-76. doi: 10.1002/cne.23198.
Parkinson's disease is a neurodegenerative disorder characterized by motor and nonmotor impairments, including constipation. The hallmark pathological features of Parkinson's disease are Lewy bodies and neurites, of which aggregated α-synuclein is a major constituent. Frequently, Lewy pathology is
PMID 22821666

Decreased acetylcholine release delays the consolidation of object recognition memory.

De Jaeger X, Cammarota M, Prado MA, Izquierdo I, Prado VF, Pereira GS.SourceMolecular Brain Research Group, Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5K8 Canada; Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5K8 Canada; Program in Molecular Pharmacology, Faculty of Medicine, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil. Electronic address: xavierdejaeger@gmail.com.
Behavioural brain research.Behav Brain Res.2013 Feb 1;238:62-8. doi: 10.1016/j.bbr.2012.10.016. Epub 2012 Oct 23.
Acetylcholine (ACh) is important for different cognitive functions such as learning, memory and attention. The release of ACh depends on its vesicular loading by the vesicular acetylcholine transporter (VAChT). It has been demonstrated that VAChT expression can modulate object recognition memory. Ho
PMID 23089649

Selective co-expression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea-pig ileum.

Sharrad DF, Gai WP, Brookes SJ.SourceDepartment of Human Physiology and Centre for Neuroscience, Flinders Medical Science and Technology, School of Medicine, Flinders University, Bedford Park, South Australia, Australia.
The Journal of comparative neurology.J Comp Neurol.2013 Jan 8. doi: 10.1002/cne.23296. [Epub ahead of print]
Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies and neurites composed mainly of the presynaptic protein, α-synuclein. Frequently, Lewy bodies and neurites are identified in the gut of Parkinson's disease patients and may underlie associated gastrointestinal dysfunct
PMID 23296877

Japanese Journal

Ginsenoside Re and Rd enhance the expression of cholinergic markers and neuronal differentiation in Neuro-2a cells

KiM Min Soo,Yu Jung Min,Kim Hee Jung,Kim Hae Bok,Kim Seung Tae,Jang Su Kil,Choi Young Wook,Lee Do Ik,Joo Seong Soo
Biological and Pharmaceutical Bulletin, 2014
… In Alzheimer's disease (AD), extensive neuronal loss and a deficiency of the neurotransmitter acetylcholine (ACh) are the major characteristics during pathogenesis in the brain. … In the present study, we aimed to investigate whether representative ginsenosides from ginseng can regulate choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT), which are required for cholinergic neurotransmission. …
NAID 130003390988

コリン作動性神経機能素子の制御機構

奥田隆志
基礎老化研究 36(3), 25-29, 2012-09-27
NAID 10031121033

中枢聴覚系のコリン線維とムスカリン性受容体

濱田聡子,トリフォノフステファン,宝谷剛志 [他],加瀬政彦,山下雄司,馬場一泰,清水順一,丸山正人,友田幸一,山下敏夫,杉本哲夫
関西医科大学雑誌 63(0), 7-9, 2012
アルツハイマー病では中枢聴覚系の機能障害を示唆する症状を合併する場合が少なくない．また細胞変性等の病変が疾病脳の聴覚上行路各部位にも確認されている．本研究ではマウス脳のこれらの部位におけるコリン線維とムスカリン性受容体（m2，m3タイプ）の発現分布密度を測定した．聴覚上行路諸核で，これらコリン線維・受容体を介する情報伝達・変換が聴覚の伝達に一定の意義を有することが，本研究から強く示唆された．
NAID 130002049985

「小胞アセチルコリン輸送体」

Solute carrier family 18 (vesicular acetylcholine transporter), member 3
Identifiers
Symbols	SLC18A3 ; VACHT
External IDs	OMIM: 600336 HomoloGene: 11022 IUPHAR: 1013 GeneCards: SLC18A3 Gene
Gene ontology
Molecular function	• acetylcholine transmembrane transporter activity;
Cellular component	• plasma membrane; • integral component of plasma membrane; • membrane; • clathrin-sculpted acetylcholine transport vesicle membrane;
Biological process	• synaptic transmission; • neurotransmitter secretion; • acetylcholine transport; • ion transmembrane transport;
	Sources: Amigo / QuickGO
Orthologs
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　　[★]

英: vesicular acetylcholine transporter、VAChT
関: 小胞アセチルコリン輸送タンパク質、小胞アセチルコリントランス・ーター

「VAChT」

　　[★]

小胞アセチルコリン輸送体

関: vesicular acetylcholine transport protein、vesicular acetylcholine transporter

「小胞アセチルコリントランスポーター」

　　[★]

英: vesicular acetylcholine transporter
関: 小胞アセチルコリン輸送体

「transport」

　　[★]

n.

輸送、運搬

v.

輸送する、運搬する、運ぶ

関: bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

「transporter」

　　[★] トランスポーター

関: translocator、transport protein、transporter protein

「vesicular」

　　[★]

adj.

小胞の

関: vesicle

「acetylcholine」

　　[★] アセチルコリン ACh

[pmid11099462-1] Erickson JD, Varoqui H (2000). "Molecular analysis of vesicular amine transporter function and targeting to secretory organelles". FASEB J. 14 (15): 2450–8. doi:10.1096/fj.00-0206rev. PMID 11099462.

[pmid8622973-2] Weihe E, Tao-Cheng JH, Schäfer MK, Erickson JD, Eiden LE (1996). "Visualization of the vesicular acetylcholine transporter in cholinergic nerve terminals and its targeting to a specific population of small synaptic vesicles". Proc. Natl. Acad. Sci. U.S.A. 93 (8): 3547–52. doi:10.1073/pnas.93.8.3547. PMC 39647. PMID 8622973.

[3] Waymire, Jack. "Storage of ACh". University of Texas Medical Center.

[pmid19203271-4] Tu Z, Efange SM, Xu J et al. (February 2009). "Synthesis and in Vitro and in Vivo Evaluation of (18)F-Labeled Positron Emission Tomography (PET) Ligands for Imaging the Vesicular Acetylcholine Transporter". J. Med. Chem. 52 (5): 1358–69. doi:10.1021/jm8012344. PMC 2765529. PMID 19203271.

リンク元	「小胞アセチルコリン輸送体」「VAChT」「小胞アセチルコリントランスポーター」
関連記事	「transport」「transporter」「vesicular」「acetylcholine」

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案内

案内

vesicular acetylcholine transporter