tropomyosin-actin binding

トロポミオシン-アクチン結合

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• 1. 心筋における興奮収縮連関excitation contraction coupling in myocardium [show details]
  …modulates calcium binding to troponin C. Troponin T serves to attach the troponin complex to actin and tropomyosin; in the relaxed state, it blocks the actin-myosin binding site. Excitation-contraction …
• 2. 赤血球細胞膜：構造、機構、動態red blood cell membrane structure organization and dynamics [show details]
  … nm). The proteins tropomyosin and tropomodulin may regulate the length of these actin filaments . Actin oligomers are critical for the organization of the junctional complex; they bind to spectrin tetramers …
• 3. 肥大型心筋症：遺伝子変異および臨床遺伝子検査hypertrophic cardiomyopathy gene mutations and clinical genetic testing [show details]
  …chain; Myosin essential light chain; Cardiac myosin binding protein-C; Cardiac alpha and beta-myosin heavy chain; Cardiac alpha actin; Alpha tropomyosin; Titin; In addition, mutations of genes associated …
• 4. 拡張能障害の細胞学的機序cellular mechanisms of diastolic dysfunction [show details]
  … myofilaments and the regulatory troponin-tropomyosin complex attached to actin and the myofilaments, actin and myosin These components can be functionally… rise rapidly and calcium binds to its myofilament receptor on troponin C, activating contractile protein tension generation via the actin-myosin cross-bridge cycle…
• 5. Isolated left ventricular noncompaction in adults: Clinical manifestations and diagnosisisolated left ventricular noncompaction in adults clinical manifestations and diagnosis [show details]
  …protein genes were found (cardiac beta-myosin heavy chain, alpha-cardiac actin, cardiac myosin-binding protein C [MYBPC3], alpha-tropomyosin [TMP1], and troponin T2) . A description of cardiac beta-myosin heavy …

English Journal

• Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

• Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W.
• Biophysical journal. 2017 Dec;113(11)2444-2451.
• Elongated tropomyosin, associated with actin-subunits along the surface of thin filaments, makes electrostatic interactions with clusters of conserved residues, K326, K328, and R147, on actin. The association is weak, permitting low-energy cost regulatory movement of tropomyosin across the filament
• PMID 29211998

• A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

• Dudin O, Merlini L, Bendezú FO, Groux R, Vincenzetti V, Martin SG.
• PLoS genetics. 2017 04;13(4)e1006721.
• In non-motile fungi, sexual reproduction relies on strong morphogenetic changes in response to pheromone signaling. We report here on a systematic screen for morphological abnormalities of the mating process in fission yeast Schizosaccharomyces pombe. We derived a homothallic (self-fertile) collecti
• PMID 28410370

• Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin.

• Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S.
• Journal of muscle research and cell motility. 2015 Dec;36(6)525-33.
• Azimuthal movement of tropomyosin around the F-actin thin filament is responsible for muscle activation and relaxation. Recently a model of αα-tropomyosin, derived from molecular-mechanics and electron microscopy of different contractile states, showed that tropomyosin is rather stiff and pre-bent
• PMID 26286845

Japanese Journal

• Periodic Binding of Troponin C・I and Troponin I to Tropomyosin-Actin Filaments

• Ohtsuki Iwao,Shiraishi Fumie
• The journal of biochemistry 131(5), 739-743, 2002-05-01
• … We investigated the distribution of troponin C•I and troponin I along tropomyosin-actin filaments by immunoelectron microscopy and found that anti-troponin I antibody form-ed transverse striations at 38 nm intervals along the bundle of filaments of both tropo-nin C•I-tropomyosin-actin and troponin I-tropomyosin-actin. …
• NAID 10010648177

• Periodic Binding of Troponin C I and Troponin I to Tropomyosin-Actin Filaments.

• Ohtsuki Iwao,Shiraishi Fumie
• The Journal of Biochemistry 131(5), 739-743, 2002
• … We investigated the distribution of troponin C•I and troponin I along tropomyosin-actin filaments by immunoelectron microscopy and found that anti-troponin I antibody form-ed transverse striations at 38 nm intervals along the bundle of filaments of both tropo-nin C•I-tropomyosin-actin and troponin I-tropomyosin-actin. …
• NAID 130003417996

Related Links

• What makes tropomyosin an actin binding protein? A perspective

Tropomyosin is a two-chained α-helical coiled coil that binds along the length of the actin filament and regulates its function. The paper addresses the question of how a “simple” coiled coil sequence encodes the ...

• Structure of the F–actin–tropomyosin complex

The coordination of ADP and the divalent cation in the nucleotide-binding cleft by nearby residues is very similar to that in G-actin (Fig. 3b, Extended Data Fig. 6b). However, glutamine 137, which has been shown to play ...

• Tropomyosin - an overview | ScienceDirect Topics

Sofia Yu. Khaitlina, in International Review of Cell and Molecular Biology, 2015 Abstract Tropomyosin is a major regulatory protein of contractile systems and cytoskeleton, an actin-binding protein that positions laterally along actin ...

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★リンクテーブル★

リンク元	「トロポミオシン-アクチン結合」
関連記事	「binding」「act」

「トロポミオシン-アクチン結合」

　　[★]

英

tropomyosin-actin binding

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「act」

　　[★]

• v.

• 作用する、行動する、働く

• n.

• 行為、(法律)条例

関

action、behave、behavior、behavioral、behaviour、behavioural、conduct、effect、work