trans-4-aminomethylcyclohexane-1-carboxylic acid

トラネキサム酸

WordNet

  1. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
  2. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
  3. having the characteristics of an acid; "an acid reaction"
  4. relating to or containing the carboxyl group or carboxyl radical (同)carboxylic
  5. the univalent radical -COOH; present in and characteristic of organic acids (同)carboxyl_group

PrepTutorEJDIC

  1. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

UpToDate Contents

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English Journal

  • [Pharmacokinetic studies with 3H-labelled synthetic antifibrinolytics].
  • Richter M, Markwardt F, Klöcking HP.AbstractIn rabbits and rats pharmacokinetic studies on the anti-fibrinolytics 4-aminomethylbenzoic acid (PAMBA), trans-4-aminomethylcyclohexane-1-carboxylic acid (AMCA), and epsilon-aminocaproic acid (EACA) were carried out using the tritium labelled compounds. Following i. v. administration of PAMBA and EACA in rabbits a two-phasic plasma level and following AMCA a three-phasic plasma level was found within 7 h. The rate constants beta of 0.34 h-1, 0.44 h-1, and 1.08 h-1 for EACA, PAMBA, and AMCA, respectively, indicate a more rapid elimination of AMCA. Accordingly, the AUC-values for AMCA are considerably smaller than those for EACA and PAMBA after both i. v. and p. o. administration.
  • Die Pharmazie.Pharmazie.1982 Dec;37(12):851-3.
  • In rabbits and rats pharmacokinetic studies on the anti-fibrinolytics 4-aminomethylbenzoic acid (PAMBA), trans-4-aminomethylcyclohexane-1-carboxylic acid (AMCA), and epsilon-aminocaproic acid (EACA) were carried out using the tritium labelled compounds. Following i. v. administration of PAMBA and EA
  • PMID 6984512
  • Kinetic studies of urokinase-catalysed hydrolysis of 5-oxo-L-prolylglycyl-L-arginine 4-nitroanilide.
  • Ipsen HH, Christensen U.AbstractThe enzymic properties of urokinase (EC 3.4.21.31) were studied. The kinetic parameters of hydrolysis of 5-oxo-Pro-Gly-Arg-NA were determined in the pH range 5-9, at 25 degrees C and 37 degrees C. The reaction is affected by only one ionizing group of urokinase with pK 7.15 (25 degrees C) and pK 6.82 (37 degrees C). The results indicate that 5-oxo-Pro-Gly-Arg-NA is a good model substrate for studies of the conversion of plasminogen to plasmin. The Km values of the urokinase-catalysed hydrolysis of plasminogen and 5-oxo-Pro-Gly-Arg-NA are of the same order of magnitude. Plasmin catalyses the hydrolysis of 5-oxo-Pro-Gly-Arg-NA, but the Km value is several hundred times that of urokinase. Urokinase is shown not to react with good plasmin substrates, such as Bz-Arg-OEt and D-Val-Leu-Lys-NA, but is linearly competitively inhibited by 6-amino-hexanoic acid and trans-4-aminomethylcyclohexane-1-carboxylic acid.
  • Biochimica et biophysica acta.Biochim Biophys Acta.1980 Jun 13;613(2):476-81.
  • The enzymic properties of urokinase (EC 3.4.21.31) were studied. The kinetic parameters of hydrolysis of 5-oxo-Pro-Gly-Arg-NA were determined in the pH range 5-9, at 25 degrees C and 37 degrees C. The reaction is affected by only one ionizing group of urokinase with pK 7.15 (25 degrees C) and pK 6.8
  • PMID 6449958
  • Inhibition of the development of the cellular slime mould Dictyostelium discoideum by omega-aminocarboxylic acids.
  • North MJ, Ashworth JM.AbstractFour omega-aminocarboxylic acids - epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexane-1-carboxylic acid (t-AMCHA), p-aminomethylbenzoic acid (PAMBA) and omega-aminocaprylic acid (OACA) -- prevented fruiting body formation of the cellular slime mould Dictyostelium discoideum. At concentrations of 40 mM, 75 mM, 10 mM and 5 mM, respectively, they allowed aggregation but prevented all further development at 24 degrees C. At lower concentrations, EACA allowed fruiting body formation but with a reduced number of spores per fruiting body. Only t-AMCHA had a significant inhibitory effect on the growth of myxamoebae. EACA affected development only if it was present between 8 and 16 h after the cells were deposited on the filters. Its effect was enhanced by high salt concentrations and by higher temperature, and was also dependent on the manner in which the cells were grown. Only strains capable of axenic growth displayed this sensitivity to EACA, although strains carrying only one of the genetic markers for axenic growth (axe A) were partially sensitive.
  • Journal of general microbiology.J Gen Microbiol.1976 Sep;96(1):63-75.
  • Four omega-aminocarboxylic acids - epsilon-aminocaproic acid (EACA), trans-4-aminomethylcyclohexane-1-carboxylic acid (t-AMCHA), p-aminomethylbenzoic acid (PAMBA) and omega-aminocaprylic acid (OACA) -- prevented fruiting body formation of the cellular slime mould Dictyostelium discoideum. At concent
  • PMID 1086340

Japanese Journal

  • Proteolytic Emzymes. III. trans-4-Aminomethylcyclohexane-1-carboxylic Acid Derivatives as Substrates and an Active Site Titrant of Trypsin
  • 谷沢 和隆,石井 信一,金岡 祐一
  • Chemical & pharmaceutical bulletin 18(11), 2346-2348, 1970-11-25
  • NAID 110003654601

Related Links

This invention relates to a process for producing a novel compound, trans-4-aminomethylcyclohexane-1-carboxylic acid. An object of the present invention is to provide a convenient process for producing trans-4 ...
This invention relates to a process for producing a novel compound, trans-4-aminomethylcyclohexane-1-carboxylic acid. An object of the present invention is to provide a convenient process for producing trans-4 ...


Related Pictures

1ddj : CRYSTAL STRUCTURE OF HUMAN  Structure of 1197-18-8 (Tranexamic acid DOMAIN OF HUMAN PLASMINOGEN WITH EACAAn Information Portal to 108789 Biological  AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID1bml : COMPLEX OF THE CATALYTIC DOMAIN OF



★リンクテーブル★
リンク元トラネキサム酸
関連記事trans」「carboxylic acid」「carboxylic」「carboxyl

トラネキサム酸」

  [★]

tranexamic acid
acidum tranexamicum
trans-4-aminomethylcyclohexane-1-carboxylic acid, t-AMCHA, 4-(aminomethyl)cyclohexane-carboxylic acid, EACA
ケイサミントランサボントランサミンバナリントッププレタスミンヘキサトロンヘムロンラノビスリカバリン
Cyklokapron


構造

  • フィブリンのリシン残基に似た構造

作用機序

  • フィブリンのリシン残基に似ているため、プラスミンがフィブリンではなくε-アミノカプロン酸に結合する。このためフィブリンの分解が抑制され、結果として線溶系が抑制される。

trans」

  [★]

t-trance

carboxylic acid」

  [★]

カルボン酸

carboxylate

carboxylic」

  [★]

  • カルボキシの
carboxy

carboxyl」

  [★]

カルボキシル